ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	189/1146	423/7206	6.8462492067e-48
ko04724	Glutamatergic synapse	84/1146	152/7206	1.80867496527e-29
ko05033	Nicotine addiction	46/1146	56/7206	5.98720981391e-28
ko05032	Morphine addiction	66/1146	110/7206	3.54489411408e-26
ko04721	Synaptic vesicle cycle	52/1146	80/7206	3.40814152171e-23
ko04727	GABAergic synapse	62/1146	110/7206	1.27922117899e-22
ko04713	Circadian entrainment	67/1146	136/7206	4.98979789949e-20
ko04728	Dopaminergic synapse	80/1146	185/7206	2.99242284623e-19
ko04725	Cholinergic synapse	71/1146	160/7206	5.94643320119e-18
ko04723	Retrograde endocannabinoid signaling	74/1146	175/7206	3.19406944882e-17
ko04742	Taste transduction	38/1146	61/7206	2.3627709284e-16
ko04024	cAMP signaling pathway	99/1146	279/7206	3.91321889491e-16
ko04911	Insulin secretion	53/1146	117/7206	3.71257976585e-14
ko04726	Serotonergic synapse	57/1146	137/7206	3.56098282069e-13
ko04020	Calcium signaling pathway	89/1146	265/7206	4.87208476546e-13
ko04744	Phototransduction	25/1146	36/7206	8.77412967138e-13
ko03040	Spliceosome	1/1146	145/7206	5.17411595903e-10
ko04261	Adrenergic signaling in cardiomyocytes	67/1146	205/7206	1.41539295165e-09
ko04921	Oxytocin signaling pathway	68/1146	209/7206	1.87227708305e-09
ko05203	Viral carcinogenesis	13/1146	277/7206	6.78175649523e-09
ko05031	Amphetamine addiction	37/1146	91/7206	1.10103260778e-08
ko04740	Olfactory transduction	34/1146	80/7206	1.13590071075e-08
ko04720	Long-term potentiation	38/1146	99/7206	7.63004872469e-08
ko04360	Axon guidance	69/1146	233/7206	8.13331817408e-08
ko04970	Salivary secretion	36/1146	95/7206	2.11986302248e-07
ko05168	Herpes simplex infection	7/1146	182/7206	3.15297249219e-07
ko05030	Cocaine addiction	29/1146	73/7206	7.64495443541e-07
ko03013	RNA transport	6/1146	166/7206	8.03957786777e-07
ko05322	Systemic lupus erythematosus	5/1146	151/7206	1.36015098695e-06
ko04060	Cytokine-cytokine receptor interaction	9/1146	191/7206	1.76730453321e-06
ko05164	Influenza A	7/1146	167/7206	2.83276225508e-06
ko04022	cGMP-PKG signaling pathway	61/1146	216/7206	2.84126752822e-06
ko04924	Renin secretion	31/1146	86/7206	4.05672940523e-06
ko04971	Gastric acid secretion	34/1146	98/7206	4.21506954577e-06
ko04966	Collecting duct acid secretion	14/1146	26/7206	8.95354415607e-06
ko04120	Ubiquitin mediated proteolysis	5/1146	138/7206	8.95496927986e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1146	74/7206	1.46719116747e-05
ko04925	Aldosterone synthesis and secretion	34/1146	105/7206	2.15142532271e-05
ko04621	NOD-like receptor signaling pathway	8/1146	157/7206	3.68147033843e-05
ko04010	MAPK signaling pathway	79/1146	321/7206	4.30681352433e-05
ko04514	Cell adhesion molecules (CAMs)	39/1146	130/7206	4.7559940198e-05
ko04141	Protein processing in endoplasmic reticulum	11/1146	184/7206	5.62673415343e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1146	79/7206	6.39853953693e-05
ko04976	Bile secretion	27/1146	80/7206	7.48128489291e-05
ko05205	Proteoglycans in cancer	21/1146	271/7206	8.61467876054e-05
ko04972	Pancreatic secretion	34/1146	111/7206	0.000106957292859
ko05110	Vibrio cholerae infection	22/1146	63/7206	0.000179974789303
ko05161	Hepatitis B	11/1146	173/7206	0.00019916600154
ko04540	Gap junction	37/1146	128/7206	0.000199742324508
ko04260	Cardiac muscle contraction	30/1146	98/7206	0.000230908182312
ko04610	Complement and coagulation cascades	2/1146	79/7206	0.000268017576886
ko03008	Ribosome biogenesis in eukaryotes	2/1146	79/7206	0.000268017576886
ko05140	Leishmaniasis	2/1146	75/7206	0.000388787919354
ko04730	Long-term depression	25/1146	78/7206	0.000440385424082
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1146	59/7206	0.000533666966084
ko05414	Dilated cardiomyopathy	32/1146	112/7206	0.000602487783955
ko04064	NF-kappa B signaling pathway	4/1146	96/7206	0.000603626101725
ko04932	Non-alcoholic fatty liver disease (NAFLD)	13/1146	182/7206	0.000626231736001
ko05169	Epstein-Barr virus infection	16/1146	206/7206	0.000660299577217
ko03018	RNA degradation	3/1146	84/7206	0.000755650017763
ko04964	Proximal tubule bicarbonate reclamation	12/1146	29/7206	0.000914210553613
ko00480	Glutathione metabolism	1/1146	55/7206	0.00132915641977
ko00240	Pyrimidine metabolism	6/1146	110/7206	0.00139738471181
ko05162	Measles	7/1146	120/7206	0.00143453904934
ko04612	Antigen processing and presentation	3/1146	77/7206	0.00153714460605
ko05133	Pertussis	4/1146	87/7206	0.00173419437527
ko00590	Arachidonic acid metabolism	1/1146	52/7206	0.00200129208865
ko04630	Jak-STAT signaling pathway	9/1146	132/7206	0.00247496771339
ko04070	Phosphatidylinositol signaling system	30/1146	112/7206	0.00263359869636
ko04640	Hematopoietic cell lineage	2/1146	64/7206	0.00284702587989
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1146	14/7206	0.00309034177884
ko04750	Inflammatory mediator regulation of TRP channels	32/1146	122/7206	0.00368972368266
ko00330	Arginine and proline metabolism	2/1146	61/7206	0.00409482057185
ko04014	Ras signaling pathway	62/1146	279/7206	0.00444819325707
ko05219	Bladder cancer	1/1146	48/7206	0.00458381351842
ko04146	Peroxisome	5/1146	89/7206	0.00510867141707
ko04072	Phospholipase D signaling pathway	46/1146	197/7206	0.00549851496002
ko05418	Fluid shear stress and atherosclerosis	15/1146	173/7206	0.00615052634866
ko03022	Basal transcription factors	1/1146	44/7206	0.00678461625941
ko04140	Autophagy - animal	14/1146	164/7206	0.00679557466349
ko05144	Malaria	1/1146	45/7206	0.00679711366281
ko00071	Fatty acid degradation	1/1146	45/7206	0.00679711366281
ko01524	Platinum drug resistance	4/1146	76/7206	0.00696877903105
ko03420	Nucleotide excision repair	1/1146	46/7206	0.0070448556415
ko04668	TNF signaling pathway	9/1146	120/7206	0.00805361849156
ko04110	Cell cycle	12/1146	145/7206	0.00826330555956
ko00280	Valine, leucine and isoleucine degradation	2/1146	54/7206	0.00846862139179
ko05321	Inflammatory bowel disease (IBD)	2/1146	56/7206	0.00882191773083
ko05206	MicroRNAs in cancer	16/1146	177/7206	0.00914630258134
ko00310	Lysine degradation	4/1146	73/7206	0.00979950551967
ko04115	p53 signaling pathway	4/1146	74/7206	0.00982795849045
ko01200	Carbon metabolism	10/1146	128/7206	0.00993476621786
ko04923	Regulation of lipolysis in adipocytes	21/1146	77/7206	0.0110749857573
ko04620	Toll-like receptor signaling pathway	7/1146	100/7206	0.0124497488334
ko05145	Toxoplasmosis	10/1146	126/7206	0.0132604368902
ko04745	Phototransduction - fly	12/1146	38/7206	0.0133783356007
ko04622	RIG-I-like receptor signaling pathway	3/1146	62/7206	0.0134855234836
ko00561	Glycerolipid metabolism	3/1146	63/7206	0.0138753558009
ko05131	Shigellosis	5/1146	82/7206	0.013931913227
ko04214	Apoptosis - fly	4/1146	72/7206	0.0139341866641
ko00290	Valine, leucine and isoleucine biosynthesis	3/1146	4/7206	0.0141430708399
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	9/1146	26/7206	0.0151975322749
ko04658	Th1 and Th2 cell differentiation	7/1146	96/7206	0.0166149505248
ko04217	Necroptosis	17/1146	178/7206	0.0167930741079
ko00380	Tryptophan metabolism	2/1146	50/7206	0.0181096655161
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1146	100/7206	0.0182827646177
ko04915	Estrogen signaling pathway	31/1146	131/7206	0.0211095926163
ko04218	Cellular senescence	17/1146	177/7206	0.0214370414567
ko05215	Prostate cancer	9/1146	111/7206	0.0251111181335
ko00620	Pyruvate metabolism	2/1146	46/7206	0.0258121628842
ko00260	Glycine, serine and threonine metabolism	2/1146	48/7206	0.0267368557666
ko05166	HTLV-I infection	33/1146	292/7206	0.0272725888093
ko04371	Apelin signaling pathway	39/1146	177/7206	0.0285534718344
ko04210	Apoptosis	18/1146	180/7206	0.0295941099594
ko04137	Mitophagy - animal	6/1146	82/7206	0.032416968899
ko00860	Porphyrin and chlorophyll metabolism	1/1146	34/7206	0.0335162185973
ko00600	Sphingolipid metabolism	4/1146	63/7206	0.0367169784288
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1146	92/7206	0.0434246791892