ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	209/1251	423/7206	1.40595490854e-55
ko04724	Glutamatergic synapse	94/1251	152/7206	3.16250308769e-35
ko05033	Nicotine addiction	49/1251	56/7206	1.63878246597e-30
ko04713	Circadian entrainment	79/1251	136/7206	4.19172463736e-27
ko05032	Morphine addiction	69/1251	110/7206	1.2734570109e-26
ko04727	GABAergic synapse	68/1251	110/7206	1.0514344203e-25
ko04721	Synaptic vesicle cycle	55/1251	80/7206	2.25343656443e-24
ko04725	Cholinergic synapse	79/1251	160/7206	5.19809602487e-21
ko04728	Dopaminergic synapse	86/1251	185/7206	1.43078251561e-20
ko04024	cAMP signaling pathway	109/1251	279/7206	1.52162019944e-18
ko04020	Calcium signaling pathway	105/1251	265/7206	3.26699231654e-18
ko04723	Retrograde endocannabinoid signaling	79/1251	175/7206	4.95044085534e-18
ko04742	Taste transduction	39/1251	61/7206	5.64060953355e-16
ko04921	Oxytocin signaling pathway	85/1251	209/7206	7.64856230537e-16
ko04911	Insulin secretion	58/1251	117/7206	7.84695949516e-16
ko04744	Phototransduction	28/1251	36/7206	2.85136141379e-15
ko04726	Serotonergic synapse	63/1251	137/7206	4.36171317266e-15
ko04720	Long-term potentiation	49/1251	99/7206	1.5452304742e-13
ko04740	Olfactory transduction	42/1251	80/7206	6.70316173534e-13
ko04970	Salivary secretion	46/1251	95/7206	2.36932664367e-12
ko04261	Adrenergic signaling in cardiomyocytes	76/1251	205/7206	7.5763574332e-12
ko05031	Amphetamine addiction	44/1251	91/7206	7.61532920622e-12
ko03040	Spliceosome	1/1251	145/7206	4.324116219e-11
ko05168	Herpes simplex infection	5/1251	182/7206	9.41269097735e-10
ko05203	Viral carcinogenesis	15/1251	277/7206	3.15103168544e-09
ko04925	Aldosterone synthesis and secretion	44/1251	105/7206	4.20834465298e-09
ko04971	Gastric acid secretion	41/1251	98/7206	1.59160326699e-08
ko04540	Gap junction	48/1251	128/7206	4.3393988949e-08
ko04360	Axon guidance	73/1251	233/7206	1.35013417662e-07
ko04060	Cytokine-cytokine receptor interaction	9/1251	191/7206	1.72774537023e-07
ko04022	cGMP-PKG signaling pathway	68/1251	216/7206	2.32183121004e-07
ko03013	RNA transport	7/1251	166/7206	3.80205338705e-07
ko05030	Cocaine addiction	31/1251	73/7206	4.01121874738e-07
ko04966	Collecting duct acid secretion	16/1251	26/7206	5.75454256017e-07
ko04120	Ubiquitin mediated proteolysis	5/1251	138/7206	1.10347822099e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1251	74/7206	2.69839653402e-06
ko04924	Renin secretion	33/1251	86/7206	4.0083704133e-06
ko05164	Influenza A	9/1251	167/7206	6.23619641523e-06
ko05169	Epstein-Barr virus infection	14/1251	206/7206	9.71886335079e-06
ko04260	Cardiac muscle contraction	35/1251	98/7206	1.06226171309e-05
ko05322	Systemic lupus erythematosus	8/1251	151/7206	1.65982671289e-05
ko04976	Bile secretion	30/1251	80/7206	1.69196016165e-05
ko04745	Phototransduction - fly	18/1251	38/7206	1.8248890221e-05
ko04972	Pancreatic secretion	38/1251	111/7206	1.98357887525e-05
ko04621	NOD-like receptor signaling pathway	9/1251	157/7206	2.46621965606e-05
ko04730	Long-term depression	29/1251	78/7206	2.74815966656e-05
ko05110	Vibrio cholerae infection	25/1251	63/7206	2.78095149979e-05
ko04010	MAPK signaling pathway	85/1251	321/7206	2.98631235589e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	24/1251	59/7206	3.20497247771e-05
ko04626	Plant-pathogen interaction	11/1251	18/7206	3.99481828939e-05
ko04070	Phosphatidylinositol signaling system	37/1251	112/7206	4.44263589931e-05
ko04514	Cell adhesion molecules (CAMs)	41/1251	130/7206	5.94002202498e-05
ko04141	Protein processing in endoplasmic reticulum	13/1251	184/7206	6.67418154003e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1251	79/7206	7.01634116578e-05
ko04964	Proximal tubule bicarbonate reclamation	14/1251	29/7206	0.000121460839865
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1251	79/7206	0.000122898350316
ko05414	Dilated cardiomyopathy	36/1251	112/7206	0.000124160828491
ko04110	Cell cycle	9/1251	145/7206	0.000134290148366
ko04750	Inflammatory mediator regulation of TRP channels	38/1251	122/7206	0.000156200514262
ko05140	Leishmaniasis	2/1251	75/7206	0.000160847555067
ko04072	Phospholipase D signaling pathway	55/1251	197/7206	0.000178822163435
ko04064	NF-kappa B signaling pathway	4/1251	96/7206	0.00018513700077
ko05162	Measles	7/1251	120/7206	0.000347306879352
ko04146	Peroxisome	4/1251	89/7206	0.000372356263901
ko04915	Estrogen signaling pathway	39/1251	131/7206	0.000410570994693
ko04610	Complement and coagulation cascades	3/1251	79/7206	0.000459204475625
ko04014	Ras signaling pathway	71/1251	279/7206	0.000500011276904
ko00520	Amino sugar and nucleotide sugar metabolism	1/1251	55/7206	0.000527482945891
ko00480	Glutathione metabolism	1/1251	55/7206	0.000527482945891
ko04371	Apelin signaling pathway	49/1251	177/7206	0.000568147029
ko04612	Antigen processing and presentation	3/1251	77/7206	0.000682120878004
ko05205	Proteoglycans in cancer	27/1251	271/7206	0.000750947391974
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1251	14/7206	0.000900342460013
ko00310	Lysine degradation	3/1251	73/7206	0.00096722822634
ko04923	Regulation of lipolysis in adipocytes	25/1251	77/7206	0.00121008356307
ko00240	Pyrimidine metabolism	7/1251	110/7206	0.00131241227016
ko04214	Apoptosis - fly	3/1251	72/7206	0.00143866605219
ko05161	Hepatitis B	15/1251	173/7206	0.00151388877923
ko03420	Nucleotide excision repair	1/1251	46/7206	0.0027870305755
ko03018	RNA degradation	5/1251	84/7206	0.00339059270335
ko04912	GnRH signaling pathway	34/1251	122/7206	0.00354001079346
ko05321	Inflammatory bowel disease (IBD)	2/1251	56/7206	0.0038065805766
ko03022	Basal transcription factors	1/1251	44/7206	0.00425139519021
ko05166	HTLV-I infection	33/1251	292/7206	0.00441037828908
ko04922	Glucagon signaling pathway	35/1251	128/7206	0.00442285967627
ko00071	Fatty acid degradation	1/1251	45/7206	0.00449679139244
ko00590	Arachidonic acid metabolism	2/1251	52/7206	0.00541438010486
ko04622	RIG-I-like receptor signaling pathway	3/1251	62/7206	0.00623700441268
ko04657	IL-17 signaling pathway	6/1251	87/7206	0.0065207268077
ko04668	TNF signaling pathway	10/1251	120/7206	0.00706025824755
ko04350	TGF-beta signaling pathway	8/1251	103/7206	0.00819758015862
ko05145	Toxoplasmosis	11/1251	126/7206	0.00858107233801
ko01524	Platinum drug resistance	5/1251	76/7206	0.0092098314466
ko00630	Glyoxylate and dicarboxylate metabolism	1/1251	38/7206	0.00954066206622
ko03410	Base excision repair	1/1251	38/7206	0.00954066206622
ko04916	Melanogenesis	37/1251	142/7206	0.00955378602266
ko00562	Inositol phosphate metabolism	25/1251	89/7206	0.0107204286077
ko00260	Glycine, serine and threonine metabolism	2/1251	48/7206	0.0116912922223
ko05131	Shigellosis	6/1251	82/7206	0.0123010791157
ko04115	p53 signaling pathway	5/1251	74/7206	0.0128159791832
ko04270	Vascular smooth muscle contraction	39/1251	154/7206	0.0128479834161
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1251	100/7206	0.0158523075987
ko05144	Malaria	2/1251	45/7206	0.016920376827
ko04330	Notch signaling pathway	4/1251	62/7206	0.0181351667126
ko00600	Sphingolipid metabolism	4/1251	63/7206	0.0182303670801
ko04640	Hematopoietic cell lineage	4/1251	64/7206	0.0187185020888
ko04630	Jak-STAT signaling pathway	13/1251	132/7206	0.0199572989089
ko04658	Th1 and Th2 cell differentiation	8/1251	96/7206	0.0200259288203
ko05231	Choline metabolism in cancer	34/1251	134/7206	0.0205255062425
ko05133	Pertussis	7/1251	87/7206	0.0215586521442
ko00500	Starch and sucrose metabolism	1/1251	35/7206	0.0222495726872
ko04015	Rap1 signaling pathway	63/1251	278/7206	0.0233810674804
ko04620	Toll-like receptor signaling pathway	9/1251	100/7206	0.0235508634098
ko05217	Basal cell carcinoma	5/1251	68/7206	0.024276931991
ko05418	Fluid shear stress and atherosclerosis	19/1251	173/7206	0.0249626455818
ko05132	Salmonella infection	9/1251	98/7206	0.0310046419179
ko04114	Oocyte meiosis	34/1251	139/7206	0.0312056571928
ko01200	Carbon metabolism	13/1251	128/7206	0.0331416323515
ko00910	Nitrogen metabolism	7/1251	19/7206	0.0342160872362
ko05222	Small cell lung cancer	8/1251	89/7206	0.0343225321615
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1251	40/7206	0.0355776553186
ko05214	Glioma	21/1251	79/7206	0.0359790000006
ko04932	Non-alcoholic fatty liver disease (NAFLD)	21/1251	182/7206	0.0369499360199
ko05034	Alcoholism	53/1251	238/7206	0.0453575634997
ko04217	Necroptosis	21/1251	178/7206	0.0453711147586
ko04062	Chemokine signaling pathway	46/1251	201/7206	0.0466493647567
ko05010	Alzheimer's disease	46/1251	202/7206	0.0472930439793
ko05320	Autoimmune thyroid disease	1/1251	29/7206	0.0478856482573
ko04930	Type II diabetes mellitus	15/1251	54/7206	0.0479276416716
ko05340	Primary immunodeficiency	1/1251	30/7206	0.0491611226017
ko04142	Lysosome	17/1251	151/7206	0.0499262683307