ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 59/630 152/7206 1.07837026102e-24 ko04727 GABAergic synapse 48/630 110/7206 6.86311999672e-23 ko05032 Morphine addiction 48/630 110/7206 6.86311999672e-23 ko05033 Nicotine addiction 33/630 56/7206 2.48071002439e-21 ko04744 Phototransduction 25/630 36/7206 5.30725850882e-19 ko04080 Neuroactive ligand-receptor interaction 95/630 423/7206 5.40360875278e-19 ko04723 Retrograde endocannabinoid signaling 55/630 175/7206 4.28472517017e-18 ko04713 Circadian entrainment 46/630 136/7206 1.07641084962e-16 ko04721 Synaptic vesicle cycle 34/630 80/7206 4.13266723984e-16 ko04728 Dopaminergic synapse 51/630 185/7206 2.99827315241e-14 ko04725 Cholinergic synapse 45/630 160/7206 4.81316741406e-13 ko04024 cAMP signaling pathway 61/630 279/7206 6.62823294473e-12 ko04726 Serotonergic synapse 38/630 137/7206 5.27684474681e-11 ko04911 Insulin secretion 34/630 117/7206 1.40509475852e-10 ko04742 Taste transduction 23/630 61/7206 4.76753441508e-10 ko04921 Oxytocin signaling pathway 44/630 209/7206 2.59946500382e-08 ko05203 Viral carcinogenesis 4/630 277/7206 3.33150281483e-07 ko04970 Salivary secretion 24/630 95/7206 1.29949789165e-06 ko04020 Calcium signaling pathway 47/630 265/7206 2.04363319744e-06 ko05030 Cocaine addiction 20/630 73/7206 2.57088705714e-06 ko05205 Proteoglycans in cancer 5/630 271/7206 2.75274180282e-06 ko04261 Adrenergic signaling in cardiomyocytes 39/630 205/7206 3.41288328525e-06 ko05164 Influenza A 1/630 167/7206 5.40592411624e-06 ko04972 Pancreatic secretion 24/630 111/7206 2.33078422278e-05 ko05031 Amphetamine addiction 21/630 91/7206 2.68110463226e-05 ko04070 Phosphatidylinositol signaling system 24/630 112/7206 2.72748403631e-05 ko03040 Spliceosome 1/630 145/7206 3.95519650935e-05 ko04060 Cytokine-cytokine receptor interaction 3/630 191/7206 4.31810270963e-05 ko05169 Epstein-Barr virus infection 4/630 206/7206 7.97934514731e-05 ko04720 Long-term potentiation 21/630 99/7206 0.00010027474376 ko04010 MAPK signaling pathway 48/630 321/7206 0.000167626489112 ko05322 Systemic lupus erythematosus 2/630 151/7206 0.00020290754612 ko04072 Phospholipase D signaling pathway 33/630 197/7206 0.000266485264559 ko04260 Cardiac muscle contraction 20/630 98/7206 0.000373325349116 ko04514 Cell adhesion molecules (CAMs) 24/630 130/7206 0.000403158154809 ko04120 Ubiquitin mediated proteolysis 2/630 138/7206 0.000630121823762 ko04730 Long-term depression 16/630 78/7206 0.000970142065965 ko04966 Collecting duct acid secretion 8/630 26/7206 0.00123019227948 ko03013 RNA transport 4/630 166/7206 0.00127254399852 ko04510 Focal adhesion 8/630 240/7206 0.00150555294784 ko05014 Amyotrophic lateral sclerosis (ALS) 15/630 74/7206 0.00157109328698 ko04110 Cell cycle 3/630 145/7206 0.00157889128552 ko05168 Herpes simplex infection 5/630 182/7206 0.00195037844473 ko04971 Gastric acid secretion 18/630 98/7206 0.00196249390331 ko04964 Proximal tubule bicarbonate reclamation 8/630 29/7206 0.00267260959334 ko05110 Vibrio cholerae infection 13/630 63/7206 0.00267947099724 ko04218 Cellular senescence 5/630 177/7206 0.0026855317175 ko05166 HTLV-I infection 12/630 292/7206 0.00285299564774 ko04740 Olfactory transduction 15/630 80/7206 0.00413529115898 ko04961 Endocrine and other factor-regulated calcium reabsorption 12/630 59/7206 0.00436691845614 ko04630 Jak-STAT signaling pathway 3/630 132/7206 0.00451358716744 ko04925 Aldosterone synthesis and secretion 18/630 105/7206 0.00473283285639 ko04932 Non-alcoholic fatty liver disease (NAFLD) 6/630 182/7206 0.00500608413139 ko05215 Prostate cancer 2/630 111/7206 0.00572769381464 ko05218 Melanoma 1/630 85/7206 0.00619610563926 ko05145 Toxoplasmosis 3/630 126/7206 0.00627457731978 ko04022 cGMP-PKG signaling pathway 31/630 216/7206 0.00657645713518 ko05034 Alcoholism 33/630 238/7206 0.00697967232851 ko04140 Autophagy - animal 5/630 164/7206 0.00711552807657 ko04350 TGF-beta signaling pathway 2/630 103/7206 0.00782684205743 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 14/630 79/7206 0.00857655596285 ko05161 Hepatitis B 6/630 173/7206 0.00917367506669 ko04540 Gap junction 20/630 128/7206 0.0103696511817 ko04810 Regulation of actin cytoskeleton 12/630 264/7206 0.010521960197 ko04915 Estrogen signaling pathway 20/630 131/7206 0.0119222172545 ko00562 Inositol phosphate metabolism 15/630 89/7206 0.0123370519391 ko04745 Phototransduction - fly 8/630 38/7206 0.0151439153285 ko05211 Renal cell carcinoma 2/630 96/7206 0.0162464620848 ko04550 Signaling pathways regulating pluripotency of stem cells 6/630 165/7206 0.0167571457857 ko04014 Ras signaling pathway 36/630 279/7206 0.0168549266265 ko00310 Lysine degradation 1/630 73/7206 0.0196457403389 ko04978 Mineral absorption 8/630 40/7206 0.0204165774268 ko05224 Breast cancer 7/630 174/7206 0.0207421174423 ko04621 NOD-like receptor signaling pathway 6/630 157/7206 0.0220847648263 ko04062 Chemokine signaling pathway 27/630 201/7206 0.0221053493279 ko05222 Small cell lung cancer 2/630 89/7206 0.022512427949 ko04976 Bile secretion 13/630 80/7206 0.0260767047417 ko00604 Glycosphingolipid biosynthesis - ganglio series 4/630 14/7206 0.0284976535376 ko05231 Choline metabolism in cancer 19/630 134/7206 0.030319986294 ko04931 Insulin resistance 5/630 137/7206 0.0313098744648 ko04212 Longevity regulating pathway - worm 2/630 87/7206 0.0327893972328 ko04141 Protein processing in endoplasmic reticulum 8/630 184/7206 0.0332089337405 ko04068 FoxO signaling pathway 7/630 167/7206 0.0362573458331 ko00290 Valine, leucine and isoleucine biosynthesis 2/630 4/7206 0.0406455582153 ko05213 Endometrial cancer 1/630 62/7206 0.0407916094731 ko00330 Arginine and proline metabolism 1/630 61/7206 0.0408022791252 ko04640 Hematopoietic cell lineage 1/630 64/7206 0.0416938437949 ko05414 Dilated cardiomyopathy 16/630 112/7206 0.042721003038 ko04064 NF-kappa B signaling pathway 3/630 96/7206 0.0453417135797 ko05212 Pancreatic cancer 2/630 83/7206 0.0468365547852