ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	204/1259	423/7206	1.72274049726e-51
ko04724	Glutamatergic synapse	91/1259	152/7206	2.64209290982e-32
ko05032	Morphine addiction	69/1259	110/7206	1.89592903071e-26
ko05033	Nicotine addiction	46/1259	56/7206	4.09611407369e-26
ko04727	GABAergic synapse	67/1259	110/7206	1.22325017633e-24
ko04713	Circadian entrainment	76/1259	136/7206	1.89835652936e-24
ko04728	Dopaminergic synapse	87/1259	185/7206	5.01622158136e-21
ko04725	Cholinergic synapse	77/1259	160/7206	1.77555163531e-19
ko04721	Synaptic vesicle cycle	50/1259	80/7206	2.23345387414e-19
ko04024	cAMP signaling pathway	108/1259	279/7206	8.61453047665e-18
ko04020	Calcium signaling pathway	102/1259	265/7206	1.19155443953e-16
ko04723	Retrograde endocannabinoid signaling	76/1259	175/7206	4.58675916174e-16
ko04726	Serotonergic synapse	64/1259	137/7206	1.39345379239e-15
ko04911	Insulin secretion	56/1259	117/7206	2.33745669453e-14
ko04742	Taste transduction	37/1259	61/7206	4.54181414487e-14
ko04921	Oxytocin signaling pathway	80/1259	209/7206	3.86078578099e-13
ko04744	Phototransduction	26/1259	36/7206	6.73041980762e-13
ko04970	Salivary secretion	45/1259	95/7206	1.3546627356e-11
ko05031	Amphetamine addiction	43/1259	91/7206	4.28967139752e-11
ko04720	Long-term potentiation	44/1259	99/7206	3.13677044193e-10
ko03010	Ribosome	1/1259	129/7206	5.72977323366e-10
ko04261	Adrenergic signaling in cardiomyocytes	70/1259	205/7206	5.79688994359e-09
ko03040	Spliceosome	3/1259	145/7206	6.08634549318e-09
ko04971	Gastric acid secretion	40/1259	98/7206	4.47463181466e-08
ko05168	Herpes simplex infection	8/1259	182/7206	9.99729071389e-08
ko05322	Systemic lupus erythematosus	5/1259	151/7206	1.04815159048e-07
ko04925	Aldosterone synthesis and secretion	41/1259	105/7206	1.50669812792e-07
ko04022	cGMP-PKG signaling pathway	68/1259	216/7206	3.69418042665e-07
ko04740	Olfactory transduction	33/1259	80/7206	6.43416450286e-07
ko05203	Viral carcinogenesis	20/1259	277/7206	6.68405436135e-07
ko03013	RNA transport	8/1259	166/7206	1.30523140717e-06
ko04730	Long-term depression	31/1259	78/7206	2.88119661367e-06
ko04966	Collecting duct acid secretion	15/1259	26/7206	4.47398882943e-06
ko05030	Cocaine addiction	29/1259	73/7206	6.25134014229e-06
ko04110	Cell cycle	7/1259	145/7206	7.00562724058e-06
ko04070	Phosphatidylinositol signaling system	39/1259	112/7206	7.6749786784e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1259	74/7206	8.17333684525e-06
ko04621	NOD-like receptor signaling pathway	9/1259	157/7206	1.68986065849e-05
ko04745	Phototransduction - fly	18/1259	38/7206	1.99806348195e-05
ko04972	Pancreatic secretion	38/1259	111/7206	2.08555198695e-05
ko04141	Protein processing in endoplasmic reticulum	13/1259	184/7206	4.76741392461e-05
ko05164	Influenza A	11/1259	167/7206	4.86680113371e-05
ko04540	Gap junction	41/1259	128/7206	5.02420141462e-05
ko04010	MAPK signaling pathway	84/1259	321/7206	6.21067702802e-05
ko04120	Ubiquitin mediated proteolysis	8/1259	138/7206	6.33746632232e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1259	79/7206	7.03252353277e-05
ko04014	Ras signaling pathway	75/1259	279/7206	7.19309990324e-05
ko04924	Renin secretion	30/1259	86/7206	8.44652537738e-05
ko04360	Axon guidance	63/1259	233/7206	0.000209602691049
ko04750	Inflammatory mediator regulation of TRP channels	38/1259	122/7206	0.000248593809802
ko04371	Apelin signaling pathway	50/1259	177/7206	0.000286940429581
ko05110	Vibrio cholerae infection	23/1259	63/7206	0.000306902118765
ko04514	Cell adhesion molecules (CAMs)	39/1259	130/7206	0.00040125051821
ko04060	Cytokine-cytokine receptor interaction	16/1259	191/7206	0.00045525482823
ko05169	Epstein-Barr virus infection	18/1259	206/7206	0.000516992513967
ko00520	Amino sugar and nucleotide sugar metabolism	1/1259	55/7206	0.000523909574357
ko04964	Proximal tubule bicarbonate reclamation	13/1259	29/7206	0.000563308641924
ko05140	Leishmaniasis	3/1259	75/7206	0.000657721881202
ko04710	Circadian rhythm	17/1259	43/7206	0.000765102154087
ko04072	Phospholipase D signaling pathway	53/1259	197/7206	0.000804448237136
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1259	79/7206	0.00083461635269
ko04976	Bile secretion	26/1259	80/7206	0.000949657446471
ko05161	Hepatitis B	15/1259	173/7206	0.00113334658762
ko05166	HTLV-I infection	31/1259	292/7206	0.00119895310116
ko04922	Glucagon signaling pathway	37/1259	128/7206	0.00134652338942
ko05414	Dilated cardiomyopathy	33/1259	112/7206	0.00154956091395
ko04064	NF-kappa B signaling pathway	6/1259	96/7206	0.00174857131317
ko05162	Measles	9/1259	120/7206	0.00226833710731
ko04915	Estrogen signaling pathway	37/1259	131/7206	0.00229058314583
ko04270	Vascular smooth muscle contraction	42/1259	154/7206	0.00245464329782
ko03420	Nucleotide excision repair	1/1259	46/7206	0.00278987214432
ko04923	Regulation of lipolysis in adipocytes	24/1259	77/7206	0.00356270485003
ko04217	Necroptosis	17/1259	178/7206	0.00359682748215
ko03022	Basal transcription factors	1/1259	44/7206	0.00427514833346
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1259	59/7206	0.0052524347289
ko04622	RIG-I-like receptor signaling pathway	3/1259	62/7206	0.00628641646818
ko04657	IL-17 signaling pathway	6/1259	87/7206	0.00650154289432
ko05133	Pertussis	6/1259	87/7206	0.00650154289432
ko04260	Cardiac muscle contraction	28/1259	98/7206	0.00676529206984
ko00562	Inositol phosphate metabolism	26/1259	89/7206	0.00689481344675
ko04626	Plant-pathogen interaction	8/1259	18/7206	0.0071005544361
ko05145	Toxoplasmosis	11/1259	126/7206	0.00867726689083
ko04612	Antigen processing and presentation	5/1259	77/7206	0.00940425077984
ko04630	Jak-STAT signaling pathway	12/1259	132/7206	0.0103590155984
ko04960	Aldosterone-regulated sodium reabsorption	14/1259	41/7206	0.0111035717926
ko05205	Proteoglycans in cancer	32/1259	271/7206	0.011308244719
ko05219	Bladder cancer	2/1259	48/7206	0.0117320660018
ko05131	Shigellosis	6/1259	82/7206	0.012274090306
ko05321	Inflammatory bowel disease (IBD)	3/1259	56/7206	0.0125889509379
ko05016	Huntington's disease	24/1259	215/7206	0.0134579529753
ko04658	Th1 and Th2 cell differentiation	8/1259	96/7206	0.0145530780546
ko04672	Intestinal immune network for IgA production	1/1259	37/7206	0.0146627880665
ko05206	MicroRNAs in cancer	19/1259	177/7206	0.0158202336056
ko04146	Peroxisome	7/1259	89/7206	0.0159669088144
ko05222	Small cell lung cancer	7/1259	89/7206	0.0159669088144
ko00240	Pyrimidine metabolism	10/1259	110/7206	0.0161776880538
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1259	100/7206	0.0163063040899
ko04610	Complement and coagulation cascades	6/1259	79/7206	0.0167240388994
ko05144	Malaria	2/1259	45/7206	0.0168913630807
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/1259	182/7206	0.0175422198406
ko04214	Apoptosis - fly	5/1259	72/7206	0.0179829319936
ko04330	Notch signaling pathway	4/1259	62/7206	0.0180523593172
ko00280	Valine, leucine and isoleucine degradation	3/1259	54/7206	0.0180593502858
ko05200	Pathways in cancer	67/1259	492/7206	0.0193348079224
ko00860	Porphyrin and chlorophyll metabolism	1/1259	34/7206	0.02150413918
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1259	14/7206	0.0236623430722
ko04015	Rap1 signaling pathway	63/1259	278/7206	0.0238813145697
ko05217	Basal cell carcinoma	5/1259	68/7206	0.0241610698437
ko04510	Focal adhesion	29/1259	240/7206	0.0244206691992
ko04115	p53 signaling pathway	6/1259	74/7206	0.0307732913542
ko04918	Thyroid hormone synthesis	23/1259	86/7206	0.0309421246816
ko04810	Regulation of actin cytoskeleton	33/1259	264/7206	0.031463215982
ko05202	Transcriptional misregulation in cancer	22/1259	188/7206	0.0324223670023
ko04350	TGF-beta signaling pathway	10/1259	103/7206	0.0360794252828
ko04210	Apoptosis	21/1259	180/7206	0.0367768733014
ko04973	Carbohydrate digestion and absorption	13/1259	42/7206	0.0381032242275
ko04912	GnRH signaling pathway	30/1259	122/7206	0.0409828632331
ko04916	Melanogenesis	34/1259	142/7206	0.0445112982486
ko00600	Sphingolipid metabolism	5/1259	63/7206	0.0450569387904
ko04062	Chemokine signaling pathway	46/1259	201/7206	0.0473917745965
ko05416	Viral myocarditis	4/1259	55/7206	0.0485046091797