ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 29/341 191/7206 1.82004371216e-08 ko04621 NOD-like receptor signaling pathway 25/341 157/7206 7.00126558864e-08 ko05164 Influenza A 25/341 167/7206 2.40930799867e-07 ko05145 Toxoplasmosis 21/341 126/7206 3.67231946608e-07 ko04380 Osteoclast differentiation 21/341 134/7206 1.05564733877e-06 ko00120 Primary bile acid biosynthesis 8/341 20/7206 1.77088886828e-06 ko04658 Th1 and Th2 cell differentiation 17/341 96/7206 2.04614980892e-06 ko04672 Intestinal immune network for IgA production 10/341 37/7206 5.47379779165e-06 ko05340 Primary immunodeficiency 9/341 30/7206 6.3330204481e-06 ko04659 Th17 cell differentiation 17/341 106/7206 8.3082690557e-06 ko05133 Pertussis 15/341 87/7206 1.15388632292e-05 ko04660 T cell receptor signaling pathway 18/341 124/7206 1.87546032654e-05 ko05150 Staphylococcus aureus infection 9/341 36/7206 3.23800362694e-05 ko04064 NF-kappa B signaling pathway 15/341 96/7206 3.88905084184e-05 ko05140 Leishmaniasis 13/341 75/7206 4.18744986139e-05 ko05162 Measles 17/341 120/7206 4.40766143832e-05 ko04630 Jak-STAT signaling pathway 18/341 132/7206 4.43593825925e-05 ko04620 Toll-like receptor signaling pathway 15/341 100/7206 6.33866574904e-05 ko04622 RIG-I-like receptor signaling pathway 11/341 62/7206 0.000131260677005 ko04650 Natural killer cell mediated cytotoxicity 14/341 97/7206 0.000169457427019 ko05323 Rheumatoid arthritis 13/341 89/7206 0.000255379182746 ko03320 PPAR signaling pathway 11/341 69/7206 0.000350069096803 ko05131 Shigellosis 12/341 82/7206 0.00043130897574 ko05168 Herpes simplex infection 20/341 182/7206 0.000487095833962 ko04623 Cytosolic DNA-sensing pathway 8/341 41/7206 0.000561211910632 ko04612 Antigen processing and presentation 11/341 77/7206 0.000914425856253 ko05321 Inflammatory bowel disease (IBD) 9/341 56/7206 0.00112911658024 ko04610 Complement and coagulation cascades 11/341 79/7206 0.0011366380848 ko05142 Chagas disease (American trypanosomiasis) 15/341 130/7206 0.00116479381194 ko05152 Tuberculosis 19/341 187/7206 0.00140214058758 ko05160 Hepatitis C 17/341 153/7206 0.00141394245398 ko00982 Drug metabolism - cytochrome P450 7/341 37/7206 0.00150405699289 ko04668 TNF signaling pathway 14/341 120/7206 0.00151502554213 ko05034 Alcoholism 2/341 238/7206 0.00153855111601 ko05320 Autoimmune thyroid disease 6/341 29/7206 0.00202246635644 ko00980 Metabolism of xenobiotics by cytochrome P450 7/341 40/7206 0.00241121062539 ko04662 B cell receptor signaling pathway 11/341 88/7206 0.00275533405611 ko00140 Steroid hormone biosynthesis 7/341 41/7206 0.00279209271375 ko00350 Tyrosine metabolism 6/341 33/7206 0.00402080977028 ko05161 Hepatitis B 17/341 173/7206 0.0052931985609 ko04217 Necroptosis 17/341 178/7206 0.0060086359286 ko05204 Chemical carcinogenesis 7/341 48/7206 0.00689071287597 ko00360 Phenylalanine metabolism 4/341 17/7206 0.00718059986869 ko05310 Asthma 4/341 17/7206 0.00718059986869 ko04146 Peroxisome 10/341 89/7206 0.00900029135869 ko00920 Sulfur metabolism 3/341 10/7206 0.00983053433749 ko04062 Chemokine signaling pathway 18/341 201/7206 0.00996024831939 ko04724 Glutamatergic synapse 1/341 152/7206 0.0104547235138 ko00590 Arachidonic acid metabolism 7/341 52/7206 0.0106591114665 ko00592 alpha-Linolenic acid metabolism 4/341 19/7206 0.0108531648532 ko04310 Wnt signaling pathway 2/341 181/7206 0.0124437319876 ko00643 Styrene degradation 2/341 4/7206 0.0125726355091 ko04933 AGE-RAGE signaling pathway in diabetic complications 13/341 135/7206 0.0126091980159 ko04728 Dopaminergic synapse 2/341 185/7206 0.0126441767286 ko04110 Cell cycle 1/341 145/7206 0.015387996187 ko04080 Neuroactive ligand-receptor interaction 10/341 423/7206 0.0174222808428 ko04723 Retrograde endocannabinoid signaling 2/341 175/7206 0.0176894148932 ko05144 Malaria 6/341 45/7206 0.0184009588421 ko00071 Fatty acid degradation 6/341 45/7206 0.0184009588421 ko04210 Apoptosis 16/341 180/7206 0.0185521441115 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/341 5/7206 0.0203022284543 ko00281 Geraniol degradation 2/341 5/7206 0.0203022284543 ko04713 Circadian entrainment 1/341 136/7206 0.022073893484 ko04726 Serotonergic synapse 1/341 137/7206 0.02235506309 ko05167 Kaposi's sarcoma-associated herpesvirus infection 16/341 191/7206 0.023420381305 ko05330 Allograft rejection 4/341 24/7206 0.0247186395576 ko05132 Salmonella infection 10/341 98/7206 0.0254398055191 ko04360 Axon guidance 4/341 233/7206 0.0263463608029 ko01524 Platinum drug resistance 8/341 76/7206 0.0265018796737 ko00362 Benzoate degradation 2/341 6/7206 0.029509364059 ko00380 Tryptophan metabolism 6/341 50/7206 0.029515447169 ko04540 Gap junction 1/341 128/7206 0.031989150378 ko00511 Other glycan degradation 4/341 26/7206 0.032307113097 ko05012 Parkinson's disease 2/341 155/7206 0.0346590101248 ko04611 Platelet activation 14/341 163/7206 0.0366397980144 ko05020 Prion diseases 5/341 40/7206 0.0389542575133 ko00480 Glutathione metabolism 6/341 55/7206 0.0443206738924 ko04911 Insulin secretion 1/341 117/7206 0.0449144392252 ko00051 Fructose and mannose metabolism 5/341 42/7206 0.0466831211813 ko00966 Glucosinolate biosynthesis 1/341 1/7206 0.047321676381 ko05206 MicroRNAs in cancer 3/341 177/7206 0.0487880090386