ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	201/1216	423/7206	5.29882515509e-52
ko04724	Glutamatergic synapse	94/1216	152/7206	2.76568249472e-36
ko05033	Nicotine addiction	50/1216	56/7206	1.12265038804e-32
ko05032	Morphine addiction	74/1216	110/7206	2.57837898139e-32
ko04727	GABAergic synapse	71/1216	110/7206	2.6116611971e-29
ko04713	Circadian entrainment	80/1216	136/7206	7.81656752817e-29
ko04728	Dopaminergic synapse	94/1216	185/7206	5.30066400193e-27
ko04725	Cholinergic synapse	81/1216	160/7206	2.9957846591e-23
ko04723	Retrograde endocannabinoid signaling	84/1216	175/7206	4.31187851574e-22
ko04721	Synaptic vesicle cycle	51/1216	80/7206	5.35336450462e-21
ko04024	cAMP signaling pathway	111/1216	279/7206	1.34808104477e-20
ko04911	Insulin secretion	60/1216	117/7206	7.39471979401e-18
ko04020	Calcium signaling pathway	102/1216	265/7206	1.43991336821e-17
ko04726	Serotonergic synapse	61/1216	137/7206	1.95362973521e-14
ko04921	Oxytocin signaling pathway	81/1216	209/7206	2.43370966767e-14
ko04742	Taste transduction	36/1216	61/7206	1.10023493335e-13
ko05031	Amphetamine addiction	46/1216	91/7206	1.10859784911e-13
ko04261	Adrenergic signaling in cardiomyocytes	78/1216	205/7206	1.71570179749e-13
ko04744	Phototransduction	26/1216	36/7206	2.89375942003e-13
ko04720	Long-term potentiation	47/1216	99/7206	1.16450240203e-12
ko04970	Salivary secretion	45/1216	95/7206	3.91086503006e-12
ko03040	Spliceosome	1/1216	145/7206	1.23203561012e-10
ko04360	Axon guidance	78/1216	233/7206	3.42540765632e-10
ko05030	Cocaine addiction	35/1216	73/7206	6.52485668379e-10
ko04925	Aldosterone synthesis and secretion	44/1216	105/7206	9.88478017137e-10
ko04971	Gastric acid secretion	42/1216	98/7206	1.03732113861e-09
ko04070	Phosphatidylinositol signaling system	43/1216	112/7206	5.63453100766e-08
ko05203	Viral carcinogenesis	17/1216	277/7206	1.10972367395e-07
ko04010	MAPK signaling pathway	91/1216	321/7206	1.58390557569e-07
ko05322	Systemic lupus erythematosus	5/1216	151/7206	2.49487739485e-07
ko04060	Cytokine-cytokine receptor interaction	9/1216	191/7206	3.78769697302e-07
ko03013	RNA transport	7/1216	166/7206	8.63580456433e-07
ko04740	Olfactory transduction	32/1216	80/7206	1.03058065972e-06
ko04022	cGMP-PKG signaling pathway	65/1216	216/7206	1.12551563118e-06
ko04972	Pancreatic secretion	39/1216	111/7206	2.46553465292e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1216	74/7206	4.77005085762e-06
ko05168	Herpes simplex infection	10/1216	182/7206	4.84018126307e-06
ko04961	Endocrine and other factor-regulated calcium reabsorption	24/1216	59/7206	1.20005872365e-05
ko04014	Ras signaling pathway	75/1216	279/7206	1.90253285716e-05
ko04540	Gap junction	41/1216	128/7206	2.17884055578e-05
ko05414	Dilated cardiomyopathy	37/1216	112/7206	3.1371690929e-05
ko04072	Phospholipase D signaling pathway	56/1216	197/7206	4.1990394029e-05
ko04730	Long-term depression	28/1216	78/7206	4.57780888241e-05
ko05110	Vibrio cholerae infection	24/1216	63/7206	5.20294610936e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1216	79/7206	5.57009941005e-05
ko04750	Inflammatory mediator regulation of TRP channels	38/1216	122/7206	7.93403869926e-05
ko04915	Estrogen signaling pathway	40/1216	131/7206	8.6210285078e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1216	79/7206	0.00011009263244
ko04924	Renin secretion	29/1216	86/7206	0.000120496980565
ko04141	Protein processing in endoplasmic reticulum	13/1216	184/7206	0.000128978508106
ko04745	Phototransduction - fly	16/1216	38/7206	0.000211752089158
ko04923	Regulation of lipolysis in adipocytes	26/1216	77/7206	0.000307225586301
ko04260	Cardiac muscle contraction	31/1216	98/7206	0.000319740457208
ko00240	Pyrimidine metabolism	6/1216	110/7206	0.000466145317792
ko04966	Collecting duct acid secretion	12/1216	26/7206	0.000478031003448
ko04912	GnRH signaling pathway	36/1216	122/7206	0.000534342693195
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1216	14/7206	0.000738973129931
ko04976	Bile secretion	26/1216	80/7206	0.000739048203554
ko05164	Influenza A	13/1216	167/7206	0.000768553908451
ko05140	Leishmaniasis	3/1216	75/7206	0.000998908735389
ko04612	Antigen processing and presentation	3/1216	77/7206	0.00104243069869
ko04640	Hematopoietic cell lineage	2/1216	64/7206	0.00118161258932
ko00590	Arachidonic acid metabolism	1/1216	52/7206	0.00125241998548
ko04110	Cell cycle	11/1216	145/7206	0.00156877667931
ko04514	Cell adhesion molecules (CAMs)	36/1216	130/7206	0.00190784674325
ko04918	Thyroid hormone synthesis	26/1216	86/7206	0.00202745289302
ko04371	Apelin signaling pathway	46/1216	177/7206	0.0021272488173
ko04621	NOD-like receptor signaling pathway	13/1216	157/7206	0.00241264261071
ko04146	Peroxisome	5/1216	89/7206	0.00247936803086
ko05205	Proteoglycans in cancer	28/1216	271/7206	0.00279792980047
ko00260	Glycine, serine and threonine metabolism	1/1216	48/7206	0.00293023130054
ko04015	Rap1 signaling pathway	66/1216	278/7206	0.003145901353
ko04064	NF-kappa B signaling pathway	6/1216	96/7206	0.00355116167662
ko05321	Inflammatory bowel disease (IBD)	2/1216	56/7206	0.00377685923338
ko03022	Basal transcription factors	1/1216	44/7206	0.00431102329269
ko05144	Malaria	1/1216	45/7206	0.00432810474661
ko00071	Fatty acid degradation	1/1216	45/7206	0.00432810474661
ko05162	Measles	9/1216	120/7206	0.00433693374721
ko03420	Nucleotide excision repair	1/1216	46/7206	0.00452382656709
ko03018	RNA degradation	5/1216	84/7206	0.00488048048761
ko00515	Mannose type O-glycan biosynthesis	10/1216	25/7206	0.00511986499763
ko00480	Glutathione metabolism	2/1216	55/7206	0.0057008117882
ko04626	Plant-pathogen interaction	8/1216	18/7206	0.00571081856387
ko05231	Choline metabolism in cancer	35/1216	134/7206	0.00694253338374
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	7/1216	15/7206	0.00702422414474
ko04120	Ubiquitin mediated proteolysis	12/1216	138/7206	0.00794581520143
ko05169	Epstein-Barr virus infection	21/1216	206/7206	0.00801898172635
ko04916	Melanogenesis	36/1216	142/7206	0.00899472566392
ko00330	Arginine and proline metabolism	3/1216	61/7206	0.00909164961775
ko04930	Type II diabetes mellitus	17/1216	54/7206	0.00914753383986
ko03320	PPAR signaling pathway	4/1216	69/7206	0.00939881530551
ko00562	Inositol phosphate metabolism	25/1216	89/7206	0.00950455452797
ko04062	Chemokine signaling pathway	48/1216	201/7206	0.00967588828017
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1216	40/7206	0.00976218438912
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1216	100/7206	0.0100500413292
ko04973	Carbohydrate digestion and absorption	14/1216	42/7206	0.0109212360029
ko04722	Neurotrophin signaling pathway	39/1216	160/7206	0.0137666990492
ko00982	Drug metabolism - cytochrome P450	1/1216	37/7206	0.0145613989391
ko00630	Glyoxylate and dicarboxylate metabolism	1/1216	38/7206	0.0148283312754
ko03410	Base excision repair	1/1216	38/7206	0.0148283312754
ko04115	p53 signaling pathway	5/1216	74/7206	0.0181437357698
ko04960	Aldosterone-regulated sodium reabsorption	13/1216	41/7206	0.0189923399488
ko04012	ErbB signaling pathway	28/1216	109/7206	0.019484724254
ko04213	Longevity regulating pathway - multiple species	23/1216	86/7206	0.0196264054838
ko04964	Proximal tubule bicarbonate reclamation	10/1216	29/7206	0.0211750417393
ko00513	Various types of N-glycan biosynthesis	13/1216	42/7206	0.0215815217653
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	9/1216	26/7206	0.0300625630786
ko05214	Glioma	21/1216	79/7206	0.0327408975478
ko04071	Sphingolipid signaling pathway	38/1216	162/7206	0.0330464567917
ko04210	Apoptosis	20/1216	180/7206	0.0344085133711
ko04962	Vasopressin-regulated water reabsorption	16/1216	58/7206	0.0346435360242
ko00140	Steroid hormone biosynthesis	2/1216	41/7206	0.036099495471
ko00983	Drug metabolism - other enzymes	2/1216	42/7206	0.0365005610726
ko04270	Vascular smooth muscle contraction	36/1216	154/7206	0.0379848940797
ko04114	Oocyte meiosis	33/1216	139/7206	0.0386104357109
ko05161	Hepatitis B	19/1216	173/7206	0.0392268567281
ko05016	Huntington's disease	25/1216	215/7206	0.0413776637262
ko01200	Carbon metabolism	13/1216	128/7206	0.0423103084964
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1216	92/7206	0.0483238573876
ko05340	Primary immunodeficiency	1/1216	30/7206	0.0486263225148