ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	209/1282	423/7206	1.21513144768e-53
ko04724	Glutamatergic synapse	90/1282	152/7206	8.37166777047e-31
ko05033	Nicotine addiction	47/1282	56/7206	4.07173829846e-27
ko05032	Morphine addiction	68/1282	110/7206	4.68655864819e-25
ko04713	Circadian entrainment	76/1282	136/7206	6.23263864773e-24
ko04721	Synaptic vesicle cycle	55/1282	80/7206	7.85087727188e-24
ko04727	GABAergic synapse	64/1282	110/7206	1.30811276627e-21
ko04728	Dopaminergic synapse	87/1282	185/7206	1.75906756168e-20
ko04020	Calcium signaling pathway	109/1282	265/7206	1.14068072557e-19
ko04725	Cholinergic synapse	77/1282	160/7206	5.44113831985e-19
ko04024	cAMP signaling pathway	109/1282	279/7206	1.44135232404e-17
ko04911	Insulin secretion	60/1282	117/7206	1.02525305135e-16
ko04723	Retrograde endocannabinoid signaling	77/1282	175/7206	3.42301783118e-16
ko04742	Taste transduction	39/1282	61/7206	1.33042170241e-15
ko04921	Oxytocin signaling pathway	85/1282	209/7206	3.89263849791e-15
ko04360	Axon guidance	87/1282	233/7206	6.82652705084e-13
ko04726	Serotonergic synapse	60/1282	137/7206	8.92082415588e-13
ko04261	Adrenergic signaling in cardiomyocytes	78/1282	205/7206	3.05748708664e-12
ko03040	Spliceosome	1/1282	145/7206	1.5951256598e-11
ko04970	Salivary secretion	45/1282	95/7206	2.57163991648e-11
ko04720	Long-term potentiation	46/1282	99/7206	3.56307541905e-11
ko05031	Amphetamine addiction	42/1282	91/7206	3.33131332943e-10
ko04744	Phototransduction	22/1282	36/7206	8.02616889513e-09
ko05168	Herpes simplex infection	7/1282	182/7206	1.1518656491e-08
ko05203	Viral carcinogenesis	17/1282	277/7206	1.26579717868e-08
ko04022	cGMP-PKG signaling pathway	71/1282	216/7206	5.79879699348e-08
ko04925	Aldosterone synthesis and secretion	42/1282	105/7206	8.51026550124e-08
ko04540	Gap junction	48/1282	128/7206	1.1955899369e-07
ko03013	RNA transport	7/1282	166/7206	1.65892963362e-07
ko04971	Gastric acid secretion	39/1282	98/7206	3.02671508802e-07
ko04060	Cytokine-cytokine receptor interaction	10/1282	191/7206	3.85717287308e-07
ko05030	Cocaine addiction	31/1282	73/7206	7.01470564644e-07
ko04740	Olfactory transduction	33/1282	80/7206	8.33593059991e-07
ko04120	Ubiquitin mediated proteolysis	6/1282	138/7206	2.75795818693e-06
ko05164	Influenza A	9/1282	167/7206	2.86669322474e-06
ko04260	Cardiac muscle contraction	37/1282	98/7206	2.99594480407e-06
ko04141	Protein processing in endoplasmic reticulum	11/1282	184/7206	3.26788101887e-06
ko04621	NOD-like receptor signaling pathway	8/1282	157/7206	3.83515953847e-06
ko04610	Complement and coagulation cascades	1/1282	79/7206	4.81813813428e-06
ko04924	Renin secretion	33/1282	86/7206	5.55282581968e-06
ko04966	Collecting duct acid secretion	15/1282	26/7206	5.65347249606e-06
ko05322	Systemic lupus erythematosus	8/1282	151/7206	7.54630716219e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1282	74/7206	1.13498928458e-05
ko04514	Cell adhesion molecules (CAMs)	43/1282	130/7206	2.22744560351e-05
ko04010	MAPK signaling pathway	87/1282	321/7206	2.54433769615e-05
ko05110	Vibrio cholerae infection	25/1282	63/7206	3.81079722505e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1282	79/7206	4.4834699891e-05
ko04371	Apelin signaling pathway	53/1282	177/7206	5.84654173319e-05
ko04976	Bile secretion	29/1282	80/7206	8.4731702994e-05
ko05140	Leishmaniasis	2/1282	75/7206	0.000101464298523
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1282	59/7206	0.000105373861307
ko04064	NF-kappa B signaling pathway	4/1282	96/7206	0.000122165377951
ko05169	Epstein-Barr virus infection	17/1282	206/7206	0.000131203424327
ko04730	Long-term depression	28/1282	78/7206	0.000132697864513
ko04972	Pancreatic secretion	36/1282	111/7206	0.000148928511712
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1282	79/7206	0.000155835680786
ko05162	Measles	7/1282	120/7206	0.000163518426325
ko05414	Dilated cardiomyopathy	36/1282	112/7206	0.000239954332191
ko04146	Peroxisome	4/1282	89/7206	0.000376257269276
ko05161	Hepatitis B	14/1282	173/7206	0.000380429801682
ko04745	Phototransduction - fly	16/1282	38/7206	0.00039696201398
ko04612	Antigen processing and presentation	3/1282	77/7206	0.000443131519351
ko00480	Glutathione metabolism	1/1282	55/7206	0.000530249198618
ko04110	Cell cycle	11/1282	145/7206	0.000599278068559
ko04014	Ras signaling pathway	72/1282	279/7206	0.000747780466144
ko00590	Arachidonic acid metabolism	1/1282	52/7206	0.000782187651223
ko00240	Pyrimidine metabolism	7/1282	110/7206	0.000925944342589
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1282	14/7206	0.00106670483248
ko04916	Melanogenesis	41/1282	142/7206	0.00116591959489
ko04915	Estrogen signaling pathway	38/1282	131/7206	0.00165469112209
ko01524	Platinum drug resistance	4/1282	76/7206	0.00223102229019
ko03018	RNA degradation	5/1282	84/7206	0.00234386292963
ko04072	Phospholipase D signaling pathway	52/1282	197/7206	0.00236380956842
ko05321	Inflammatory bowel disease (IBD)	2/1282	56/7206	0.00244136611589
ko04070	Phosphatidylinositol signaling system	33/1282	112/7206	0.00250228741695
ko05205	Proteoglycans in cancer	30/1282	271/7206	0.0026314392664
ko04750	Inflammatory mediator regulation of TRP channels	35/1282	122/7206	0.00264750668016
ko00071	Fatty acid degradation	1/1282	45/7206	0.00272566723604
ko03022	Basal transcription factors	1/1282	44/7206	0.00272694435532
ko03420	Nucleotide excision repair	1/1282	46/7206	0.00285576821476
ko04640	Hematopoietic cell lineage	3/1282	64/7206	0.00289433445294
ko05131	Shigellosis	5/1282	82/7206	0.0033139041264
ko00280	Valine, leucine and isoleucine degradation	2/1282	54/7206	0.0036281926474
ko04622	RIG-I-like receptor signaling pathway	3/1282	62/7206	0.0041779903983
ko00561	Glycerolipid metabolism	3/1282	63/7206	0.00424871370365
ko05133	Pertussis	6/1282	87/7206	0.0046306029453
ko04214	Apoptosis - fly	4/1282	72/7206	0.00464186808929
ko04668	TNF signaling pathway	10/1282	120/7206	0.00522847235805
ko04217	Necroptosis	18/1282	178/7206	0.00528384461391
ko04270	Vascular smooth muscle contraction	41/1282	154/7206	0.00545068812659
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1282	40/7206	0.00619453311889
ko05145	Toxoplasmosis	11/1282	126/7206	0.00643469082379
ko04630	Jak-STAT signaling pathway	12/1282	132/7206	0.00777250459906
ko04626	Plant-pathogen interaction	8/1282	18/7206	0.00794592807218
ko04620	Toll-like receptor signaling pathway	8/1282	100/7206	0.00797489072862
ko00380	Tryptophan metabolism	2/1282	50/7206	0.00806306338367
ko05418	Fluid shear stress and atherosclerosis	18/1282	173/7206	0.00865202235111
ko04115	p53 signaling pathway	5/1282	74/7206	0.00904004258064
ko00982	Drug metabolism - cytochrome P450	1/1282	37/7206	0.0093815252808
ko03410	Base excision repair	1/1282	38/7206	0.00938672747114
ko04923	Regulation of lipolysis in adipocytes	23/1282	77/7206	0.00990144073832
ko04015	Rap1 signaling pathway	66/1282	278/7206	0.0103358794218
ko04964	Proximal tubule bicarbonate reclamation	11/1282	29/7206	0.0115562117474
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1282	100/7206	0.0116155621733
ko00260	Glycine, serine and threonine metabolism	2/1282	48/7206	0.0120384634518
ko00600	Sphingolipid metabolism	4/1282	63/7206	0.0127241813254
ko04922	Glucagon signaling pathway	34/1282	128/7206	0.013685667956
ko00500	Starch and sucrose metabolism	1/1282	35/7206	0.0140518158078
ko04912	GnRH signaling pathway	32/1282	122/7206	0.0169501757997
ko05144	Malaria	2/1282	45/7206	0.017037637792
ko03320	PPAR signaling pathway	5/1282	69/7206	0.0173645301867
ko00330	Arginine and proline metabolism	4/1282	61/7206	0.0178486633106
ko00640	Propanoate metabolism	1/1282	34/7206	0.0217338784071
ko00140	Steroid hormone biosynthesis	2/1282	41/7206	0.0242720663148
ko00983	Drug metabolism - other enzymes	2/1282	42/7206	0.0243597869257
ko04114	Oocyte meiosis	35/1282	139/7206	0.0250361148305
ko00310	Lysine degradation	6/1282	73/7206	0.0305064999472
ko04930	Type II diabetes mellitus	16/1282	54/7206	0.0306506008028
ko04658	Th1 and Th2 cell differentiation	9/1282	96/7206	0.0306954714209
ko04142	Lysosome	17/1282	151/7206	0.0315772629628
ko05340	Primary immunodeficiency	1/1282	30/7206	0.0317097945976
ko05215	Prostate cancer	11/1282	111/7206	0.0324124992041
ko04918	Thyroid hormone synthesis	23/1282	86/7206	0.0334646459505
ko04657	IL-17 signaling pathway	8/1282	87/7206	0.0338936302402
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	9/1282	26/7206	0.0362506125048
ko04932	Non-alcoholic fatty liver disease (NAFLD)	22/1282	182/7206	0.0394878399076
ko05120	Epithelial cell signaling in Helicobacter pylori infection	24/1282	92/7206	0.0400371962145
ko04933	AGE-RAGE signaling pathway in diabetic complications	15/1282	135/7206	0.0405783524236
ko00564	Glycerophospholipid metabolism	10/1282	99/7206	0.0464006028955
ko05146	Amoebiasis	10/1282	99/7206	0.0464006028955
ko01200	Carbon metabolism	14/1282	128/7206	0.046465591642
ko05320	Autoimmune thyroid disease	1/1282	29/7206	0.0480626170344