ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	189/1246	423/7206	3.94945907141e-42
ko04724	Glutamatergic synapse	83/1246	152/7206	5.33201503378e-26
ko05033	Nicotine addiction	45/1246	56/7206	5.36044235701e-25
ko04713	Circadian entrainment	69/1246	136/7206	2.02906568396e-19
ko04020	Calcium signaling pathway	107/1246	265/7206	2.06563739271e-19
ko05032	Morphine addiction	60/1246	110/7206	4.66411435908e-19
ko04727	GABAergic synapse	59/1246	110/7206	2.75231580906e-18
ko04728	Dopaminergic synapse	79/1246	185/7206	2.0620982085e-16
ko04721	Synaptic vesicle cycle	46/1246	80/7206	4.30305448704e-16
ko04024	cAMP signaling pathway	103/1246	279/7206	1.22742755641e-15
ko04723	Retrograde endocannabinoid signaling	71/1246	175/7206	2.56393702445e-13
ko04725	Cholinergic synapse	66/1246	160/7206	5.23718503514e-13
ko04921	Oxytocin signaling pathway	79/1246	209/7206	6.65059271661e-13
ko04911	Insulin secretion	51/1246	117/7206	1.95413913344e-11
ko04022	cGMP-PKG signaling pathway	76/1246	216/7206	1.13894342566e-10
ko04726	Serotonergic synapse	55/1246	137/7206	1.57368015252e-10
ko04742	Taste transduction	32/1246	61/7206	3.54492237151e-10
ko03010	Ribosome	1/1246	129/7206	9.29100485424e-10
ko04261	Adrenergic signaling in cardiomyocytes	70/1246	205/7206	2.99054167658e-09
ko05031	Amphetamine addiction	39/1246	91/7206	8.39858335187e-09
ko04970	Salivary secretion	40/1246	95/7206	1.00133889778e-08
ko04744	Phototransduction	21/1246	36/7206	3.34650957603e-08
ko03040	Spliceosome	4/1246	145/7206	5.11831825031e-08
ko05203	Viral carcinogenesis	18/1246	277/7206	1.03198526707e-07
ko04720	Long-term potentiation	39/1246	99/7206	1.40140613931e-07
ko05168	Herpes simplex infection	8/1246	182/7206	1.48018861352e-07
ko05322	Systemic lupus erythematosus	5/1246	151/7206	1.62640664595e-07
ko04971	Gastric acid secretion	37/1246	98/7206	1.13284767056e-06
ko04925	Aldosterone synthesis and secretion	39/1246	105/7206	1.31964769367e-06
ko03013	RNA transport	8/1246	166/7206	1.95484124754e-06
ko04110	Cell cycle	7/1246	145/7206	1.05444721214e-05
ko05164	Influenza A	10/1246	167/7206	1.80659143616e-05
ko05030	Cocaine addiction	27/1246	73/7206	5.77676772997e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1246	74/7206	6.91596698808e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1246	79/7206	7.04439650873e-05
ko04745	Phototransduction - fly	17/1246	38/7206	7.34986226415e-05
ko04060	Cytokine-cytokine receptor interaction	14/1246	191/7206	8.86619368253e-05
ko05161	Hepatitis B	12/1246	173/7206	9.32757957806e-05
ko04371	Apelin signaling pathway	51/1246	177/7206	0.000114240843695
ko04966	Collecting duct acid secretion	13/1246	26/7206	0.000129815683881
ko04710	Circadian rhythm	18/1246	43/7206	0.000130621461286
ko05140	Leishmaniasis	2/1246	75/7206	0.000159835048886
ko04260	Cardiac muscle contraction	32/1246	98/7206	0.000211740564054
ko04730	Long-term depression	27/1246	78/7206	0.000212015014531
ko04922	Glucagon signaling pathway	39/1246	128/7206	0.000213069342001
ko05169	Epstein-Barr virus infection	17/1246	206/7206	0.000239727465031
ko04621	NOD-like receptor signaling pathway	11/1246	157/7206	0.0002460474964
ko04070	Phosphatidylinositol signaling system	35/1246	112/7206	0.000337897288316
ko05162	Measles	7/1246	120/7206	0.000343102018063
ko04120	Ubiquitin mediated proteolysis	9/1246	138/7206	0.000358557658463
ko04964	Proximal tubule bicarbonate reclamation	13/1246	29/7206	0.000507549730334
ko04514	Cell adhesion molecules (CAMs)	38/1246	130/7206	0.000623903004328
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1246	79/7206	0.000774393510855
ko05166	HTLV-I infection	30/1246	292/7206	0.00085752188595
ko04740	Olfactory transduction	26/1246	80/7206	0.000864066324967
ko04350	TGF-beta signaling pathway	6/1246	103/7206	0.000900575396345
ko04010	MAPK signaling pathway	78/1246	321/7206	0.00112008395485
ko04330	Notch signaling pathway	2/1246	62/7206	0.00114788790728
ko05414	Dilated cardiomyopathy	33/1246	112/7206	0.00143182784389
ko04630	Jak-STAT signaling pathway	10/1246	132/7206	0.00161059312322
ko04270	Vascular smooth muscle contraction	42/1246	154/7206	0.00167434533333
ko04072	Phospholipase D signaling pathway	51/1246	197/7206	0.00211008942944
ko04972	Pancreatic secretion	32/1246	111/7206	0.00222417523443
ko04064	NF-kappa B signaling pathway	6/1246	96/7206	0.00248654306896
ko04141	Protein processing in endoplasmic reticulum	17/1246	184/7206	0.00285797681305
ko05205	Proteoglycans in cancer	29/1246	271/7206	0.00306951558237
ko04915	Estrogen signaling pathway	36/1246	131/7206	0.00330647291991
ko04923	Regulation of lipolysis in adipocytes	24/1246	77/7206	0.00342600926374
ko04750	Inflammatory mediator regulation of TRP channels	34/1246	122/7206	0.00344935020713
ko04930	Type II diabetes mellitus	18/1246	54/7206	0.00351692669987
ko04014	Ras signaling pathway	67/1246	279/7206	0.00355101859667
ko04924	Renin secretion	26/1246	86/7206	0.0035949243981
ko00520	Amino sugar and nucleotide sugar metabolism	2/1246	55/7206	0.00369574007444
ko03022	Basal transcription factors	1/1246	44/7206	0.0042436549467
ko04540	Gap junction	35/1246	128/7206	0.0043156958826
ko04976	Bile secretion	24/1246	80/7206	0.0044021830058
ko04214	Apoptosis - fly	4/1246	72/7206	0.004634687324
ko04217	Necroptosis	17/1246	178/7206	0.00471629120025
ko04622	RIG-I-like receptor signaling pathway	3/1246	62/7206	0.00621996173654
ko04658	Th1 and Th2 cell differentiation	7/1246	96/7206	0.00631662417454
ko04657	IL-17 signaling pathway	6/1246	87/7206	0.00655272044077
ko05133	Pertussis	6/1246	87/7206	0.00655272044077
ko04610	Complement and coagulation cascades	5/1246	79/7206	0.00664154904616
ko04626	Plant-pathogen interaction	8/1246	18/7206	0.0066550394388
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1246	100/7206	0.00722416400046
ko00010	Glycolysis / Gluconeogenesis	22/1246	74/7206	0.00785730617325
ko04550	Signaling pathways regulating pluripotency of stem cells	16/1246	165/7206	0.00881474837173
ko05130	Pathogenic Escherichia coli infection	5/1246	77/7206	0.00929511405033
ko00240	Pyrimidine metabolism	9/1246	110/7206	0.0103707660668
ko05110	Vibrio cholerae infection	19/1246	63/7206	0.0110920110908
ko05219	Bladder cancer	2/1246	48/7206	0.0116829685047
ko05131	Shigellosis	6/1246	82/7206	0.0123486734262
ko05321	Inflammatory bowel disease (IBD)	3/1246	56/7206	0.01268216094
ko04672	Intestinal immune network for IgA production	1/1246	37/7206	0.0145390582328
ko04210	Apoptosis	19/1246	180/7206	0.0161005008072
ko03420	Nucleotide excision repair	2/1246	46/7206	0.0171976120527
ko00710	Carbon fixation in photosynthetic organisms	10/1246	27/7206	0.0172517483771
ko05145	Toxoplasmosis	12/1246	126/7206	0.0172856464853
ko05416	Viral myocarditis	3/1246	55/7206	0.018373268952
ko05200	Pathways in cancer	66/1246	492/7206	0.0187867562218
ko05206	MicroRNAs in cancer	19/1246	177/7206	0.0201148778768
ko01230	Biosynthesis of amino acids	23/1246	85/7206	0.020828273556
ko04960	Aldosterone-regulated sodium reabsorption	13/1246	41/7206	0.0212946317614
ko00860	Porphyrin and chlorophyll metabolism	1/1246	34/7206	0.0215091619286
ko05215	Prostate cancer	10/1246	111/7206	0.0218335048907
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1246	14/7206	0.0225459391037
ko00562	Inositol phosphate metabolism	24/1246	89/7206	0.0228382011434
ko04612	Antigen processing and presentation	6/1246	77/7206	0.0228896079565
ko04620	Toll-like receptor signaling pathway	9/1246	100/7206	0.0236337806824
ko04113	Meiosis - yeast	5/1246	70/7206	0.0247190245042
ko04360	Axon guidance	53/1246	233/7206	0.0277707524384
ko04142	Lysosome	16/1246	151/7206	0.0289998861167
ko05220	Chronic myeloid leukemia	7/1246	85/7206	0.029071144145
ko05010	Alzheimer's disease	47/1246	202/7206	0.0294234409465
ko00230	Purine metabolism	45/1246	194/7206	0.0337341959689
ko05222	Small cell lung cancer	8/1246	89/7206	0.0344074098594
ko05020	Prion diseases	2/1246	40/7206	0.0356526119031
ko00190	Oxidative phosphorylation	31/1246	127/7206	0.0431062471298
ko01200	Carbon metabolism	31/1246	128/7206	0.0442532698374
ko04213	Longevity regulating pathway - multiple species	22/1246	86/7206	0.0450429342539