ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	178/1159	423/7206	7.77078199384e-40
ko04724	Glutamatergic synapse	83/1159	152/7206	2.84416899841e-28
ko04721	Synaptic vesicle cycle	55/1159	80/7206	4.4567835437e-26
ko05033	Nicotine addiction	43/1159	56/7206	8.51719680892e-24
ko04727	GABAergic synapse	58/1159	110/7206	4.4409846659e-19
ko04713	Circadian entrainment	66/1159	136/7206	4.95036778467e-19
ko05032	Morphine addiction	57/1159	110/7206	2.66304521368e-18
ko04728	Dopaminergic synapse	78/1159	185/7206	1.04205565627e-17
ko04725	Cholinergic synapse	70/1159	160/7206	4.89352222521e-17
ko04742	Taste transduction	36/1159	61/7206	2.39267196063e-14
ko04723	Retrograde endocannabinoid signaling	69/1159	175/7206	8.04792133202e-14
ko04911	Insulin secretion	52/1159	117/7206	2.66331338634e-13
ko04024	cAMP signaling pathway	93/1159	279/7206	4.03120076448e-13
ko04921	Oxytocin signaling pathway	74/1159	209/7206	4.40232300401e-12
ko04740	Olfactory transduction	39/1159	80/7206	7.7601076812e-12
ko04726	Serotonergic synapse	55/1159	137/7206	8.35010821882e-12
ko04744	Phototransduction	24/1159	36/7206	1.27858476774e-11
ko03040	Spliceosome	1/1159	145/7206	3.15923482734e-10
ko04020	Calcium signaling pathway	82/1159	265/7206	7.32053354978e-10
ko04261	Adrenergic signaling in cardiomyocytes	67/1159	205/7206	2.90748675895e-09
ko05203	Viral carcinogenesis	13/1159	277/7206	3.14863408017e-09
ko05031	Amphetamine addiction	38/1159	91/7206	3.94116056954e-09
ko05168	Herpes simplex infection	5/1159	182/7206	8.37250909615e-09
ko04720	Long-term potentiation	39/1159	99/7206	1.76179580581e-08
ko04966	Collecting duct acid secretion	17/1159	26/7206	2.11958459479e-08
ko04060	Cytokine-cytokine receptor interaction	7/1159	191/7206	6.90708492331e-08
ko05164	Influenza A	5/1159	167/7206	8.86962194144e-08
ko04120	Ubiquitin mediated proteolysis	3/1159	138/7206	1.32509396755e-07
ko04971	Gastric acid secretion	37/1159	98/7206	1.80615242901e-07
ko04260	Cardiac muscle contraction	36/1159	98/7206	5.17394928392e-07
ko03013	RNA transport	6/1159	166/7206	5.28340315531e-07
ko04970	Salivary secretion	35/1159	95/7206	6.98608197046e-07
ko04360	Axon guidance	67/1159	233/7206	7.00088572012e-07
ko04964	Proximal tubule bicarbonate reclamation	16/1159	29/7206	1.52766095336e-06
ko05030	Cocaine addiction	28/1159	73/7206	3.40073841623e-06
ko04621	NOD-like receptor signaling pathway	7/1159	157/7206	8.13407642643e-06
ko04925	Aldosterone synthesis and secretion	35/1159	105/7206	1.10656035719e-05
ko05162	Measles	4/1159	120/7206	1.42579248252e-05
ko04141	Protein processing in endoplasmic reticulum	10/1159	184/7206	1.48596324492e-05
ko05322	Systemic lupus erythematosus	7/1159	151/7206	1.65800570219e-05
ko04924	Renin secretion	30/1159	86/7206	1.88942813742e-05
ko05169	Epstein-Barr virus infection	13/1159	206/7206	2.89066649386e-05
ko04514	Cell adhesion molecules (CAMs)	40/1159	130/7206	2.9067409192e-05
ko04976	Bile secretion	28/1159	80/7206	3.79612633211e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1159	79/7206	7.20650416429e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1159	74/7206	7.90076255881e-05
ko04540	Gap junction	38/1159	128/7206	8.60799676724e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1159	59/7206	9.32391867486e-05
ko04745	Phototransduction - fly	16/1159	38/7206	0.000118262331929
ko05161	Hepatitis B	11/1159	173/7206	0.000143022970398
ko04022	cGMP-PKG signaling pathway	56/1159	216/7206	0.000155017545764
ko05166	HTLV-I infection	25/1159	292/7206	0.000170014160573
ko04010	MAPK signaling pathway	77/1159	321/7206	0.000176623553697
ko04612	Antigen processing and presentation	2/1159	77/7206	0.000258434352168
ko03008	Ribosome biogenesis in eukaryotes	2/1159	79/7206	0.000277197521653
ko05140	Leishmaniasis	2/1159	75/7206	0.000385501788749
ko04064	NF-kappa B signaling pathway	4/1159	96/7206	0.000408547240213
ko04730	Long-term depression	25/1159	78/7206	0.000474428472723
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1159	14/7206	0.000527871566912
ko04110	Cell cycle	9/1159	145/7206	0.000528668278192
ko04214	Apoptosis - fly	2/1159	72/7206	0.000567864381644
ko05414	Dilated cardiomyopathy	32/1159	112/7206	0.000681718749188
ko05110	Vibrio cholerae infection	21/1159	63/7206	0.000750029065526
ko05205	Proteoglycans in cancer	25/1159	271/7206	0.00128252723139
ko00520	Amino sugar and nucleotide sugar metabolism	1/1159	55/7206	0.00132938002571
ko00480	Glutathione metabolism	1/1159	55/7206	0.00132938002571
ko04972	Pancreatic secretion	31/1159	111/7206	0.00153914574937
ko04640	Hematopoietic cell lineage	2/1159	64/7206	0.00182408673887
ko03018	RNA degradation	4/1159	84/7206	0.00245909908452
ko01200	Carbon metabolism	9/1159	128/7206	0.00331786634508
ko04014	Ras signaling pathway	63/1159	279/7206	0.00357074822962
ko04668	TNF signaling pathway	8/1159	120/7206	0.00357446214349
ko00240	Pyrimidine metabolism	7/1159	110/7206	0.0036342705693
ko03420	Nucleotide excision repair	1/1159	46/7206	0.00449384991319
ko04610	Complement and coagulation cascades	4/1159	79/7206	0.00496741340728
ko04657	IL-17 signaling pathway	5/1159	87/7206	0.00504252247469
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1159	100/7206	0.00553016883208
ko05321	Inflammatory bowel disease (IBD)	2/1159	56/7206	0.00575845632264
ko05418	Fluid shear stress and atherosclerosis	15/1159	173/7206	0.00614746848826
ko00910	Nitrogen metabolism	8/1159	19/7206	0.00626157156165
ko03022	Basal transcription factors	1/1159	44/7206	0.00670636735297
ko04140	Autophagy - animal	14/1159	164/7206	0.00682465158943
ko00071	Fatty acid degradation	1/1159	45/7206	0.00683497358103
ko01524	Platinum drug resistance	4/1159	76/7206	0.00695661879314
ko04750	Inflammatory mediator regulation of TRP channels	31/1159	122/7206	0.00844333970647
ko04978	Mineral absorption	13/1159	40/7206	0.00857781922941
ko05215	Prostate cancer	8/1159	111/7206	0.00863857307718
ko04620	Toll-like receptor signaling pathway	7/1159	100/7206	0.00907588794859
ko00561	Glycerolipid metabolism	3/1159	63/7206	0.00933140012169
ko00310	Lysine degradation	4/1159	73/7206	0.0097355447808
ko05145	Toxoplasmosis	10/1159	126/7206	0.00981298026801
ko05212	Pancreatic cancer	5/1159	83/7206	0.00982674133208
ko04115	p53 signaling pathway	4/1159	74/7206	0.00992243122332
ko04974	Protein digestion and absorption	25/1159	96/7206	0.0112590708158
ko04630	Jak-STAT signaling pathway	11/1159	132/7206	0.0117778517801
ko00590	Arachidonic acid metabolism	2/1159	52/7206	0.0123810849975
ko04011	MAPK signaling pathway - yeast	2/1159	53/7206	0.0128709066382
ko04622	RIG-I-like receptor signaling pathway	3/1159	62/7206	0.0136314466408
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1159	40/7206	0.0153729156206
ko04626	Plant-pathogen interaction	7/1159	18/7206	0.0170092682127
ko00260	Glycine, serine and threonine metabolism	2/1159	48/7206	0.017762178493
ko05219	Bladder cancer	2/1159	48/7206	0.017762178493
ko05133	Pertussis	6/1159	87/7206	0.0177893720518
ko04933	AGE-RAGE signaling pathway in diabetic complications	12/1159	135/7206	0.0180546111314
ko04350	TGF-beta signaling pathway	8/1159	103/7206	0.0206631725267
ko04915	Estrogen signaling pathway	31/1159	131/7206	0.0220856130558
ko00982	Drug metabolism - cytochrome P450	1/1159	37/7206	0.0226226967203
ko04139	Mitophagy - yeast	1/1159	37/7206	0.0226226967203
ko00630	Glyoxylate and dicarboxylate metabolism	1/1159	38/7206	0.0235479426641
ko03410	Base excision repair	1/1159	38/7206	0.0235479426641
ko04218	Cellular senescence	18/1159	177/7206	0.0292926885883
ko04146	Peroxisome	7/1159	89/7206	0.029606861204
ko05222	Small cell lung cancer	7/1159	89/7206	0.029606861204
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1159	92/7206	0.0306631684712
ko05131	Shigellosis	6/1159	82/7206	0.0327291629086
ko00860	Porphyrin and chlorophyll metabolism	1/1159	34/7206	0.0334186894058
ko00500	Starch and sucrose metabolism	1/1159	35/7206	0.0343298527209
ko04658	Th1 and Th2 cell differentiation	8/1159	96/7206	0.0356222479046
ko00600	Sphingolipid metabolism	4/1159	63/7206	0.036900343179
ko00280	Valine, leucine and isoleucine degradation	3/1159	54/7206	0.0383773378182
ko05144	Malaria	2/1159	45/7206	0.0385169901063
ko04210	Apoptosis	19/1159	180/7206	0.0398340382633
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1159	182/7206	0.0402195857344
ko05202	Transcriptional misregulation in cancer	20/1159	188/7206	0.0435512740405
ko04217	Necroptosis	19/1159	178/7206	0.0491917846505