ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	212/1294	423/7206	4.6019440965e-55
ko04724	Glutamatergic synapse	95/1294	152/7206	7.03910762568e-35
ko05033	Nicotine addiction	50/1294	56/7206	2.47751793343e-31
ko05032	Morphine addiction	73/1294	110/7206	1.79242259527e-29
ko04713	Circadian entrainment	80/1294	136/7206	6.4465822229e-27
ko04727	GABAergic synapse	70/1294	110/7206	1.26913215999e-26
ko04721	Synaptic vesicle cycle	56/1294	80/7206	1.17763771505e-24
ko04728	Dopaminergic synapse	90/1294	185/7206	3.78561851799e-22
ko04725	Cholinergic synapse	80/1294	160/7206	9.58969563774e-21
ko04020	Calcium signaling pathway	110/1294	265/7206	6.93130552883e-20
ko04024	cAMP signaling pathway	113/1294	279/7206	1.92572408645e-19
ko04723	Retrograde endocannabinoid signaling	81/1294	175/7206	2.36469100203e-18
ko04911	Insulin secretion	60/1294	117/7206	1.62231111828e-16
ko04742	Taste transduction	39/1294	61/7206	1.84252626939e-15
ko04921	Oxytocin signaling pathway	85/1294	209/7206	5.81431750144e-15
ko04744	Phototransduction	28/1294	36/7206	7.0199336103e-15
ko04726	Serotonergic synapse	63/1294	137/7206	2.28538128904e-14
ko04720	Long-term potentiation	50/1294	99/7206	1.23388546242e-13
ko05031	Amphetamine addiction	46/1294	91/7206	1.14962463982e-12
ko04970	Salivary secretion	47/1294	95/7206	1.79159092134e-12
ko04740	Olfactory transduction	42/1294	80/7206	2.17237190676e-12
ko04261	Adrenergic signaling in cardiomyocytes	78/1294	205/7206	6.78543878577e-12
ko03040	Spliceosome	1/1294	145/7206	1.56691191449e-11
ko05203	Viral carcinogenesis	16/1294	277/7206	2.05036674892e-09
ko04925	Aldosterone synthesis and secretion	45/1294	105/7206	2.89869531383e-09
ko04971	Gastric acid secretion	42/1294	98/7206	1.05081890625e-08
ko04360	Axon guidance	77/1294	233/7206	1.64855817532e-08
ko04022	cGMP-PKG signaling pathway	72/1294	216/7206	3.78095576978e-08
ko05168	Herpes simplex infection	8/1294	182/7206	4.38066301446e-08
ko04966	Collecting duct acid secretion	17/1294	26/7206	1.15637346556e-07
ko03013	RNA transport	7/1294	166/7206	1.70146669253e-07
ko05030	Cocaine addiction	32/1294	73/7206	2.39751744815e-07
ko04060	Cytokine-cytokine receptor interaction	10/1294	191/7206	2.57186862183e-07
ko04540	Gap junction	47/1294	128/7206	3.30255412751e-07
ko04924	Renin secretion	34/1294	86/7206	2.62538398516e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1294	74/7206	4.54178098608e-06
ko04972	Pancreatic secretion	40/1294	111/7206	4.55314467553e-06
ko05322	Systemic lupus erythematosus	8/1294	151/7206	7.75427521929e-06
ko04070	Phosphatidylinositol signaling system	40/1294	112/7206	8.55667782141e-06
ko05164	Influenza A	10/1294	167/7206	8.58607538666e-06
ko04141	Protein processing in endoplasmic reticulum	12/1294	184/7206	9.14857733768e-06
ko04120	Ubiquitin mediated proteolysis	7/1294	138/7206	9.51180933134e-06
ko04961	Endocrine and other factor-regulated calcium reabsorption	25/1294	59/7206	1.03596325953e-05
ko04514	Cell adhesion molecules (CAMs)	44/1294	130/7206	1.34320363033e-05
ko05110	Vibrio cholerae infection	26/1294	63/7206	1.59138250192e-05
ko04730	Long-term depression	30/1294	78/7206	1.77534775949e-05
ko04010	MAPK signaling pathway	88/1294	321/7206	1.95254314726e-05
ko04745	Phototransduction - fly	18/1294	38/7206	2.94452344436e-05
ko04621	NOD-like receptor signaling pathway	10/1294	157/7206	3.30763566521e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1294	79/7206	4.44054072934e-05
ko04626	Plant-pathogen interaction	11/1294	18/7206	5.54537643063e-05
ko04750	Inflammatory mediator regulation of TRP channels	40/1294	122/7206	6.67106764123e-05
ko04014	Ras signaling pathway	76/1294	279/7206	8.84563094298e-05
ko04976	Bile secretion	29/1294	80/7206	9.31431400274e-05
ko05169	Epstein-Barr virus infection	17/1294	206/7206	9.56114019853e-05
ko04260	Cardiac muscle contraction	33/1294	98/7206	0.000160857200375
ko05162	Measles	7/1294	120/7206	0.000162466124859
ko04110	Cell cycle	10/1294	145/7206	0.000171842880858
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1294	79/7206	0.000175052897192
ko04915	Estrogen signaling pathway	41/1294	131/7206	0.000193758206022
ko04072	Phospholipase D signaling pathway	56/1294	197/7206	0.000224438319331
ko04146	Peroxisome	4/1294	89/7206	0.000244622091957
ko05414	Dilated cardiomyopathy	36/1294	112/7206	0.000259129542026
ko04064	NF-kappa B signaling pathway	5/1294	96/7206	0.000405046149879
ko04612	Antigen processing and presentation	3/1294	77/7206	0.000450316303352
ko05205	Proteoglycans in cancer	28/1294	271/7206	0.00049991937268
ko00520	Amino sugar and nucleotide sugar metabolism	1/1294	55/7206	0.000543600375547
ko05140	Leishmaniasis	3/1294	75/7206	0.000673133200294
ko04371	Apelin signaling pathway	50/1294	177/7206	0.000676092266819
ko04964	Proximal tubule bicarbonate reclamation	13/1294	29/7206	0.000740495805054
ko04923	Regulation of lipolysis in adipocytes	26/1294	77/7206	0.000817754297813
ko04610	Complement and coagulation cascades	4/1294	79/7206	0.00107027572588
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1294	14/7206	0.00113758059641
ko03420	Nucleotide excision repair	1/1294	46/7206	0.00177928263025
ko00480	Glutathione metabolism	2/1294	55/7206	0.00241563902752
ko03022	Basal transcription factors	1/1294	44/7206	0.00268585996483
ko05144	Malaria	1/1294	45/7206	0.00273694988397
ko00071	Fatty acid degradation	1/1294	45/7206	0.00273694988397
ko04214	Apoptosis - fly	4/1294	72/7206	0.00313952064099
ko00310	Lysine degradation	4/1294	73/7206	0.0031608221976
ko05161	Hepatitis B	17/1294	173/7206	0.00350849071469
ko04912	GnRH signaling pathway	35/1294	122/7206	0.00394421850283
ko04622	RIG-I-like receptor signaling pathway	3/1294	62/7206	0.00416586240005
ko05145	Toxoplasmosis	11/1294	126/7206	0.00472124514396
ko00240	Pyrimidine metabolism	9/1294	110/7206	0.00550672977774
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1294	182/7206	0.00599795863586
ko03018	RNA degradation	6/1294	84/7206	0.00634410318931
ko01524	Platinum drug resistance	5/1294	76/7206	0.00643482482183
ko04922	Glucagon signaling pathway	35/1294	128/7206	0.00735200012344
ko04270	Vascular smooth muscle contraction	41/1294	154/7206	0.00758368586002
ko04916	Melanogenesis	38/1294	142/7206	0.00788268372884
ko00562	Inositol phosphate metabolism	26/1294	89/7206	0.00798276617957
ko04015	Rap1 signaling pathway	67/1294	278/7206	0.00840580770786
ko05131	Shigellosis	6/1294	82/7206	0.00874791594001
ko04115	p53 signaling pathway	5/1294	74/7206	0.00900707087794
ko00630	Glyoxylate and dicarboxylate metabolism	1/1294	38/7206	0.009415253369
ko05166	HTLV-I infection	36/1294	292/7206	0.010022668272
ko04918	Thyroid hormone synthesis	25/1294	86/7206	0.0104131988228
ko04658	Th1 and Th2 cell differentiation	8/1294	96/7206	0.0106338749307
ko05321	Inflammatory bowel disease (IBD)	3/1294	56/7206	0.0128826946439
ko00500	Starch and sucrose metabolism	1/1294	35/7206	0.0139637497866
ko05418	Fluid shear stress and atherosclerosis	19/1294	173/7206	0.0156547096349
ko04657	IL-17 signaling pathway	7/1294	87/7206	0.015850737142
ko05133	Pertussis	7/1294	87/7206	0.015850737142
ko05231	Choline metabolism in cancer	35/1294	134/7206	0.0167081312972
ko04620	Toll-like receptor signaling pathway	9/1294	100/7206	0.0175296041254
ko04668	TNF signaling pathway	12/1294	120/7206	0.0220031307127
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1294	100/7206	0.0247633660023
ko05222	Small cell lung cancer	8/1294	89/7206	0.0254904236494
ko05214	Glioma	22/1294	79/7206	0.0266257519018
ko04350	TGF-beta signaling pathway	10/1294	103/7206	0.027341389035
ko05120	Epithelial cell signaling in Helicobacter pylori infection	25/1294	92/7206	0.027731314097
ko04630	Jak-STAT signaling pathway	14/1294	132/7206	0.0288485340984
ko04062	Chemokine signaling pathway	48/1294	201/7206	0.0316887399714
ko04640	Hematopoietic cell lineage	5/1294	64/7206	0.0326228161499
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1294	40/7206	0.0359277084494
ko05206	MicroRNAs in cancer	21/1294	177/7206	0.0366593999365
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1294	15/7206	0.038132828803
ko05034	Alcoholism	55/1294	238/7206	0.0391731805988
ko04973	Carbohydrate digestion and absorption	13/1294	42/7206	0.0408604418798
ko00330	Arginine and proline metabolism	5/1294	61/7206	0.0444569110182
ko04330	Notch signaling pathway	5/1294	62/7206	0.0447119265285
ko00600	Sphingolipid metabolism	5/1294	63/7206	0.0457287479093
ko05132	Salmonella infection	10/1294	98/7206	0.0461685997761
ko05215	Prostate cancer	12/1294	111/7206	0.0464352391113
ko04217	Necroptosis	22/1294	178/7206	0.0481031451655
ko00280	Valine, leucine and isoleucine degradation	4/1294	54/7206	0.0482614395415
ko05320	Autoimmune thyroid disease	1/1294	29/7206	0.0483478971372
ko04210	Apoptosis	22/1294	180/7206	0.0484992009532