ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	209/1292	423/7206	4.95588008736e-53
ko04724	Glutamatergic synapse	91/1292	152/7206	2.16989123232e-31
ko05033	Nicotine addiction	50/1292	56/7206	2.29422491114e-31
ko05032	Morphine addiction	72/1292	110/7206	1.50235964966e-28
ko04713	Circadian entrainment	81/1292	136/7206	8.22578259633e-28
ko04727	GABAergic synapse	69/1292	110/7206	9.4866408245e-26
ko04725	Cholinergic synapse	80/1292	160/7206	8.66886679498e-21
ko04721	Synaptic vesicle cycle	52/1292	80/7206	1.02136375047e-20
ko04728	Dopaminergic synapse	87/1292	185/7206	3.00547226637e-20
ko04911	Insulin secretion	62/1292	117/7206	5.51747639188e-18
ko04723	Retrograde endocannabinoid signaling	80/1292	175/7206	8.84442603223e-18
ko04024	cAMP signaling pathway	108/1292	279/7206	8.74565070075e-17
ko04020	Calcium signaling pathway	104/1292	265/7206	1.12184827721e-16
ko04742	Taste transduction	38/1292	61/7206	1.40414349188e-14
ko04921	Oxytocin signaling pathway	84/1292	209/7206	2.64462222637e-14
ko04726	Serotonergic synapse	62/1292	137/7206	8.53559365245e-14
ko04744	Phototransduction	27/1292	36/7206	9.88669013775e-14
ko04261	Adrenergic signaling in cardiomyocytes	77/1292	205/7206	1.44325747874e-11
ko03040	Spliceosome	1/1292	145/7206	1.5591164563e-11
ko04970	Salivary secretion	45/1292	95/7206	3.38148497534e-11
ko04720	Long-term potentiation	46/1292	99/7206	4.69957741183e-11
ko04740	Olfactory transduction	40/1292	80/7206	5.13226632603e-11
ko05031	Amphetamine addiction	43/1292	91/7206	1.02640905943e-10
ko04360	Axon guidance	80/1292	233/7206	1.0036953249e-09
ko05203	Viral carcinogenesis	16/1292	277/7206	2.0712842699e-09
ko04925	Aldosterone synthesis and secretion	45/1292	105/7206	2.82297934257e-09
ko03013	RNA transport	6/1292	166/7206	2.77200750139e-08
ko04022	cGMP-PKG signaling pathway	72/1292	216/7206	3.68672242088e-08
ko05168	Herpes simplex infection	8/1292	182/7206	6.69254102897e-08
ko04971	Gastric acid secretion	40/1292	98/7206	8.4916155776e-08
ko05030	Cocaine addiction	32/1292	73/7206	2.31076988624e-07
ko05322	Systemic lupus erythematosus	6/1292	151/7206	2.79346775455e-07
ko04060	Cytokine-cytokine receptor interaction	11/1292	191/7206	1.18401150037e-06
ko05164	Influenza A	9/1292	167/7206	1.97745135316e-06
ko04141	Protein processing in endoplasmic reticulum	11/1292	184/7206	2.2853673345e-06
ko04976	Bile secretion	32/1292	80/7206	2.84223219287e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1292	74/7206	4.41842598379e-06
ko04730	Long-term depression	31/1292	78/7206	4.74052997739e-06
ko04010	MAPK signaling pathway	90/1292	321/7206	4.80446198827e-06
ko04961	Endocrine and other factor-regulated calcium reabsorption	25/1292	59/7206	1.0071501227e-05
ko04621	NOD-like receptor signaling pathway	9/1292	157/7206	1.17365521707e-05
ko04540	Gap junction	43/1292	128/7206	1.97225103152e-05
ko04924	Renin secretion	32/1292	86/7206	2.37096944995e-05
ko04745	Phototransduction - fly	18/1292	38/7206	2.88109262952e-05
ko04972	Pancreatic secretion	38/1292	111/7206	2.95574543536e-05
ko04120	Ubiquitin mediated proteolysis	8/1292	138/7206	4.30285141896e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1292	79/7206	4.44011165382e-05
ko04014	Ras signaling pathway	76/1292	279/7206	8.67463926779e-05
ko04371	Apelin signaling pathway	53/1292	177/7206	9.0622034028e-05
ko05140	Leishmaniasis	2/1292	75/7206	0.000102322698211
ko04260	Cardiac muscle contraction	33/1292	98/7206	0.000157965805802
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1292	79/7206	0.000171571613954
ko04110	Cell cycle	10/1292	145/7206	0.000171838663929
ko04966	Collecting duct acid secretion	13/1292	26/7206	0.000190358953436
ko05169	Epstein-Barr virus infection	18/1292	206/7206	0.000211618332488
ko04072	Phospholipase D signaling pathway	56/1292	197/7206	0.000219779490939
ko04146	Peroxisome	4/1292	89/7206	0.00024515243189
ko04610	Complement and coagulation cascades	3/1292	79/7206	0.000301036691528
ko04514	Cell adhesion molecules (CAMs)	40/1292	130/7206	0.000303016818745
ko05110	Vibrio cholerae infection	23/1292	63/7206	0.000396952595211
ko04064	NF-kappa B signaling pathway	5/1292	96/7206	0.000404344431556
ko04612	Antigen processing and presentation	3/1292	77/7206	0.000448531770744
ko05162	Measles	8/1292	120/7206	0.000661697053658
ko04750	Inflammatory mediator regulation of TRP channels	37/1292	122/7206	0.000752047520621
ko00590	Arachidonic acid metabolism	1/1292	52/7206	0.00078575053082
ko00330	Arginine and proline metabolism	2/1292	61/7206	0.00112600292514
ko05414	Dilated cardiomyopathy	34/1292	112/7206	0.00113326438809
ko04070	Phosphatidylinositol signaling system	34/1292	112/7206	0.00113326438809
ko04657	IL-17 signaling pathway	5/1292	87/7206	0.00168709766278
ko05161	Hepatitis B	16/1292	173/7206	0.00175467302085
ko03420	Nucleotide excision repair	1/1292	46/7206	0.00178498520468
ko05205	Proteoglycans in cancer	30/1292	271/7206	0.00207901687017
ko04217	Necroptosis	17/1292	178/7206	0.00207972456879
ko03018	RNA degradation	5/1292	84/7206	0.00234321379076
ko00240	Pyrimidine metabolism	8/1292	110/7206	0.00236122151201
ko04923	Regulation of lipolysis in adipocytes	25/1292	77/7206	0.00236669514203
ko00480	Glutathione metabolism	2/1292	55/7206	0.00242134387659
ko05321	Inflammatory bowel disease (IBD)	2/1292	56/7206	0.00244287992313
ko04916	Melanogenesis	40/1292	142/7206	0.00261915701376
ko04964	Proximal tubule bicarbonate reclamation	12/1292	29/7206	0.0026852896112
ko03022	Basal transcription factors	1/1292	44/7206	0.00269129519148
ko05144	Malaria	1/1292	45/7206	0.00273354907269
ko00071	Fatty acid degradation	1/1292	45/7206	0.00273354907269
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1292	182/7206	0.00316914527407
ko04915	Estrogen signaling pathway	37/1292	131/7206	0.00373745077959
ko04622	RIG-I-like receptor signaling pathway	3/1292	62/7206	0.0041649058271
ko05133	Pertussis	6/1292	87/7206	0.00459068540191
ko04015	Rap1 signaling pathway	68/1292	278/7206	0.00514876985658
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1292	40/7206	0.00618006432108
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1292	14/7206	0.00621539991552
ko04270	Vascular smooth muscle contraction	41/1292	154/7206	0.0075394371703
ko00380	Tryptophan metabolism	2/1292	50/7206	0.00818579524466
ko04626	Plant-pathogen interaction	8/1292	18/7206	0.00833719821575
ko05131	Shigellosis	6/1292	82/7206	0.00875477350961
ko04115	p53 signaling pathway	5/1292	74/7206	0.00900598600865
ko00310	Lysine degradation	5/1292	73/7206	0.00901375459919
ko00982	Drug metabolism - cytochrome P450	1/1292	37/7206	0.0092855254999
ko04658	Th1 and Th2 cell differentiation	8/1292	96/7206	0.0106461664353
ko00620	Pyruvate metabolism	2/1292	46/7206	0.011336844375
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1292	100/7206	0.0120541856431
ko00280	Valine, leucine and isoleucine degradation	3/1292	54/7206	0.0123610589711
ko04214	Apoptosis - fly	5/1292	72/7206	0.0125919631014
ko04640	Hematopoietic cell lineage	4/1292	64/7206	0.0128970963783
ko00500	Starch and sucrose metabolism	1/1292	35/7206	0.0139742412042
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	10/1292	26/7206	0.0167271871454
ko04620	Toll-like receptor signaling pathway	9/1292	100/7206	0.0175208474299
ko01200	Carbon metabolism	13/1292	128/7206	0.019588288103
ko00640	Propanoate metabolism	1/1292	34/7206	0.0219289511177
ko04918	Thyroid hormone synthesis	24/1292	86/7206	0.0225194064007
ko01524	Platinum drug resistance	6/1292	76/7206	0.022822219552
ko04912	GnRH signaling pathway	32/1292	122/7206	0.0228860525735
ko05132	Salmonella infection	9/1292	98/7206	0.0233002154209
ko05166	HTLV-I infection	38/1292	292/7206	0.0239004023719
ko00140	Steroid hormone biosynthesis	2/1292	41/7206	0.0241048487231
ko05215	Prostate cancer	11/1292	111/7206	0.0244840495155
ko05418	Fluid shear stress and atherosclerosis	20/1292	173/7206	0.0269341408814
ko04630	Jak-STAT signaling pathway	14/1292	132/7206	0.0287906887281
ko04140	Autophagy - animal	19/1292	164/7206	0.0305228994471
ko04142	Lysosome	17/1292	151/7206	0.0314996356836
ko00270	Cysteine and methionine metabolism	3/1292	47/7206	0.0355188684502
ko00562	Inositol phosphate metabolism	24/1292	89/7206	0.0356483902346
ko05204	Chemical carcinogenesis	3/1292	48/7206	0.0358893788264
ko00260	Glycine, serine and threonine metabolism	3/1292	48/7206	0.0358893788264
ko04722	Neurotrophin signaling pathway	39/1292	160/7206	0.0367933684218
ko05016	Huntington's disease	27/1292	215/7206	0.037650484126
ko04113	Meiosis - yeast	6/1292	70/7206	0.0409633063981
ko00600	Sphingolipid metabolism	5/1292	63/7206	0.0456315159402
ko05145	Toxoplasmosis	14/1292	126/7206	0.0459047395018
ko04922	Glucagon signaling pathway	32/1292	128/7206	0.0470591037824
ko05320	Autoimmune thyroid disease	1/1292	29/7206	0.0482919868285
ko04210	Apoptosis	22/1292	180/7206	0.0484104725745