ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko03040	Spliceosome	101/815	145/7206	2.48091060992e-63
ko03013	RNA transport	82/815	166/7206	3.79002314017e-35
ko04110	Cell cycle	67/815	145/7206	1.21915048953e-26
ko03008	Ribosome biogenesis in eukaryotes	47/815	79/7206	3.67388168362e-25
ko04080	Neuroactive ligand-receptor interaction	1/815	423/7206	1.78592768039e-21
ko04111	Cell cycle - yeast	45/815	90/7206	5.86908135356e-20
ko03030	DNA replication	28/815	38/7206	3.19703773828e-19
ko03015	mRNA surveillance pathway	43/815	93/7206	1.74407970175e-17
ko00240	Pyrimidine metabolism	43/815	110/7206	2.98819255935e-14
ko03020	RNA polymerase	20/815	29/7206	3.50264861325e-13
ko03410	Base excision repair	23/815	38/7206	3.72651946735e-13
ko04144	Endocytosis	5/815	342/7206	2.20160712936e-12
ko04113	Meiosis - yeast	31/815	70/7206	2.47136657465e-12
ko04020	Calcium signaling pathway	2/815	265/7206	8.15625166769e-12
ko03022	Basal transcription factors	23/815	44/7206	2.48323804513e-11
ko03420	Nucleotide excision repair	23/815	46/7206	8.12913779291e-11
ko03430	Mismatch repair	15/815	22/7206	4.46002976034e-10
ko03018	RNA degradation	31/815	84/7206	6.81398669198e-10
ko03440	Homologous recombination	20/815	41/7206	2.4823313033e-09
ko05010	Alzheimer's disease	2/815	202/7206	1.31635151071e-08
ko05169	Epstein-Barr virus infection	52/815	206/7206	1.60821486635e-08
ko03460	Fanconi anemia pathway	21/815	51/7206	4.2841101179e-08
ko04723	Retrograde endocannabinoid signaling	2/815	175/7206	3.37696147841e-07
ko04724	Glutamatergic synapse	1/815	152/7206	3.74448054601e-07
ko05322	Systemic lupus erythematosus	38/815	151/7206	1.41058422054e-06
ko04726	Serotonergic synapse	1/815	137/7206	1.89334420763e-06
ko00230	Purine metabolism	44/815	194/7206	4.7351302362e-06
ko04921	Oxytocin signaling pathway	6/815	209/7206	1.125489397e-05
ko04725	Cholinergic synapse	3/815	160/7206	1.16321055426e-05
ko04024	cAMP signaling pathway	11/815	279/7206	1.19653069523e-05
ko04010	MAPK signaling pathway	14/815	321/7206	1.22624434148e-05
ko05168	Herpes simplex infection	41/815	182/7206	1.30642070791e-05
ko04713	Circadian entrainment	2/815	136/7206	2.57405428121e-05
ko04022	cGMP-PKG signaling pathway	7/815	216/7206	2.57802982605e-05
ko04072	Phospholipase D signaling pathway	6/815	197/7206	3.1913375646e-05
ko05414	Dilated cardiomyopathy	1/815	112/7206	3.22283857973e-05
ko04915	Estrogen signaling pathway	2/815	131/7206	3.66069962936e-05
ko04932	Non-alcoholic fatty liver disease (NAFLD)	5/815	182/7206	4.05443167758e-05
ko04727	GABAergic synapse	1/815	110/7206	4.92375913848e-05
ko05032	Morphine addiction	1/815	110/7206	4.92375913848e-05
ko04261	Adrenergic signaling in cardiomyocytes	7/815	205/7206	7.11647239773e-05
ko04062	Chemokine signaling pathway	7/815	201/7206	9.88551238124e-05
ko04151	PI3K-Akt signaling pathway	22/815	390/7206	0.000104347742383
ko04330	Notch signaling pathway	18/815	62/7206	0.000111675123177
ko04912	GnRH signaling pathway	2/815	122/7206	0.000121695198049
ko04270	Vascular smooth muscle contraction	4/815	154/7206	0.000143400456398
ko04810	Regulation of actin cytoskeleton	12/815	264/7206	0.000145433968558
ko04380	Osteoclast differentiation	3/815	134/7206	0.00015766068028
ko05146	Amoebiasis	1/815	99/7206	0.000162075374476
ko05410	Hypertrophic cardiomyopathy (HCM)	1/815	100/7206	0.000167182117653
ko04911	Insulin secretion	2/815	117/7206	0.000171149819198
ko05166	HTLV-I infection	54/815	292/7206	0.000209965491589
ko04371	Apelin signaling pathway	6/815	177/7206	0.000253591166122
ko04650	Natural killer cell mediated cytotoxicity	1/815	97/7206	0.000255178962498
ko04712	Circadian rhythm - plant	5/815	7/7206	0.000315817555998
ko04621	NOD-like receptor signaling pathway	5/815	157/7206	0.000316089466704
ko04014	Ras signaling pathway	14/815	279/7206	0.00032250335069
ko05145	Toxoplasmosis	3/815	126/7206	0.000327953661369
ko04540	Gap junction	3/815	128/7206	0.000334044099653
ko03010	Ribosome	3/815	129/7206	0.000344151043624
ko04510	Focal adhesion	11/815	240/7206	0.000370508178325
ko04972	Pancreatic secretion	2/815	111/7206	0.000377895674361
ko04925	Aldosterone synthesis and secretion	2/815	105/7206	0.000529414075451
ko04662	B cell receptor signaling pathway	1/815	88/7206	0.000531147537467
ko04920	Adipocytokine signaling pathway	1/815	89/7206	0.000543738177066
ko05203	Viral carcinogenesis	50/815	277/7206	0.000658842189322
ko03050	Proteasome	15/815	54/7206	0.000690201450574
ko05231	Choline metabolism in cancer	4/815	134/7206	0.000798889015844
ko04924	Renin secretion	1/815	86/7206	0.000824327169245
ko04530	Tight junction	11/815	228/7206	0.000889461760865
ko04120	Ubiquitin mediated proteolysis	29/815	138/7206	0.000925938500714
ko04015	Rap1 signaling pathway	15/815	278/7206	0.000934045066441
ko04114	Oocyte meiosis	29/815	139/7206	0.000984346374146
ko04620	Toll-like receptor signaling pathway	2/815	100/7206	0.00116031639939
ko04976	Bile secretion	1/815	80/7206	0.00116463289208
ko04070	Phosphatidylinositol signaling system	3/815	112/7206	0.00138769446079
ko04360	Axon guidance	12/815	233/7206	0.00148504006281
ko01200	Carbon metabolism	4/815	128/7206	0.00164039405904
ko04730	Long-term depression	1/815	78/7206	0.00175918845692
ko04610	Complement and coagulation cascades	1/815	79/7206	0.00182028855799
ko04139	Mitophagy - yeast	11/815	37/7206	0.00193306844161
ko04750	Inflammatory mediator regulation of TRP channels	4/815	122/7206	0.00221886781688
ko05120	Epithelial cell signaling in Helicobacter pylori infection	2/815	92/7206	0.00239366467204
ko04670	Leukocyte transendothelial migration	6/815	151/7206	0.00249168149245
ko05030	Cocaine addiction	1/815	73/7206	0.00255554983879
ko05140	Leishmaniasis	1/815	75/7206	0.0026488973917
ko04728	Dopaminergic synapse	9/815	185/7206	0.00308301508532
ko04668	TNF signaling pathway	4/815	120/7206	0.00318331519667
ko05202	Transcriptional misregulation in cancer	35/815	188/7206	0.00321330582791
ko05133	Pertussis	2/815	87/7206	0.00341423903313
ko04146	Peroxisome	2/815	89/7206	0.0035134016917
ko05142	Chagas disease (American trypanosomiasis)	5/815	130/7206	0.00463767348111
ko05132	Salmonella infection	3/815	98/7206	0.0056986116103
ko04611	Platelet activation	8/815	163/7206	0.00578100741531
ko00564	Glycerophospholipid metabolism	3/815	99/7206	0.00579877471014
ko05160	Hepatitis C	7/815	153/7206	0.00618045358075
ko04660	T cell receptor signaling pathway	5/815	124/7206	0.00621699900946
ko05034	Alcoholism	41/815	238/7206	0.00643951782838
ko04071	Sphingolipid signaling pathway	8/815	162/7206	0.0078462717922
ko05110	Vibrio cholerae infection	1/815	63/7206	0.00827124769362
ko00561	Glycerolipid metabolism	1/815	63/7206	0.00827124769362
ko00600	Sphingolipid metabolism	1/815	63/7206	0.00827124769362
ko04933	AGE-RAGE signaling pathway in diabetic complications	6/815	135/7206	0.00849425712464
ko04910	Insulin signaling pathway	9/815	172/7206	0.0098485125041
ko04923	Regulation of lipolysis in adipocytes	2/815	77/7206	0.0102580948854
ko00562	Inositol phosphate metabolism	3/815	89/7206	0.0112678420055
ko05031	Amphetamine addiction	3/815	91/7206	0.0113882448794
ko04962	Vasopressin-regulated water reabsorption	1/815	58/7206	0.0121339231721
ko04659	Th17 cell differentiation	4/815	106/7206	0.012193494101
ko05152	Tuberculosis	11/815	187/7206	0.0138957838971
ko00520	Amino sugar and nucleotide sugar metabolism	1/815	55/7206	0.0177910892843
ko05321	Inflammatory bowel disease (IBD)	1/815	56/7206	0.0179435431461
ko04142	Lysosome	8/815	151/7206	0.0184031118853
ko04931	Insulin resistance	7/815	137/7206	0.0195776141001
ko04630	Jak-STAT signaling pathway	7/815	132/7206	0.0256806004463
ko00590	Arachidonic acid metabolism	1/815	52/7206	0.0261868691776
ko04930	Type II diabetes mellitus	1/815	54/7206	0.0274505939252
ko00280	Valine, leucine and isoleucine degradation	1/815	54/7206	0.0274505939252
ko04914	Progesterone-mediated oocyte maturation	19/815	104/7206	0.0290615974525
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	3/815	79/7206	0.0308405888752
ko04512	ECM-receptor interaction	3/815	79/7206	0.0308405888752
ko04310	Wnt signaling pathway	30/815	181/7206	0.0314436914754
ko04138	Autophagy - yeast	3/815	81/7206	0.0318059858995
ko04145	Phagosome	10/815	162/7206	0.0330026131499
ko04218	Cellular senescence	29/815	177/7206	0.0400113262803
ko04212	Longevity regulating pathway - worm	16/815	87/7206	0.0413053394124
ko00330	Arginine and proline metabolism	2/815	61/7206	0.0421040874156
ko05134	Legionellosis	3/815	74/7206	0.0427042651636
ko04623	Cytosolic DNA-sensing pathway	9/815	41/7206	0.0436415818555
ko04370	VEGF signaling pathway	3/815	77/7206	0.0438285312254
ko04664	Fc epsilon RI signaling pathway	3/815	77/7206	0.0438285312254