ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	193/1219	423/7206	2.82191107747e-46
ko04724	Glutamatergic synapse	89/1219	152/7206	1.09116868626e-31
ko05033	Nicotine addiction	47/1219	56/7206	4.00052284699e-28
ko05032	Morphine addiction	67/1219	110/7206	1.75873923967e-25
ko04713	Circadian entrainment	76/1219	136/7206	2.24605421716e-25
ko04727	GABAergic synapse	65/1219	110/7206	1.05452318585e-23
ko04721	Synaptic vesicle cycle	51/1219	80/7206	6.00058047004e-21
ko04725	Cholinergic synapse	77/1219	160/7206	2.36438870475e-20
ko04728	Dopaminergic synapse	83/1219	185/7206	2.03975768952e-19
ko04723	Retrograde endocannabinoid signaling	77/1219	175/7206	1.74025655228e-17
ko04024	cAMP signaling pathway	104/1219	279/7206	7.33284327218e-17
ko04020	Calcium signaling pathway	100/1219	265/7206	1.80346404435e-16
ko04726	Serotonergic synapse	63/1219	137/7206	1.20616099153e-15
ko04742	Taste transduction	38/1219	61/7206	1.95735501559e-15
ko04921	Oxytocin signaling pathway	81/1219	209/7206	2.58295826351e-14
ko04911	Insulin secretion	54/1219	117/7206	1.14176373972e-13
ko04970	Salivary secretion	44/1219	95/7206	1.92753770005e-11
ko04261	Adrenergic signaling in cardiomyocytes	73/1219	205/7206	6.75298902185e-11
ko03040	Spliceosome	1/1219	145/7206	7.23770504011e-11
ko04720	Long-term potentiation	44/1219	99/7206	1.05646116568e-10
ko05031	Amphetamine addiction	41/1219	91/7206	2.74462117618e-10
ko04744	Phototransduction	23/1219	36/7206	3.62558967762e-10
ko03010	Ribosome	1/1219	129/7206	1.526716202e-09
ko05203	Viral carcinogenesis	17/1219	277/7206	7.71920201754e-08
ko04360	Axon guidance	71/1219	233/7206	1.83138258522e-07
ko04022	cGMP-PKG signaling pathway	67/1219	216/7206	2.52738920857e-07
ko05168	Herpes simplex infection	8/1219	182/7206	3.32255691785e-07
ko04971	Gastric acid secretion	37/1219	98/7206	7.98780383758e-07
ko03013	RNA transport	7/1219	166/7206	8.76270817054e-07
ko04740	Olfactory transduction	32/1219	80/7206	1.05694459059e-06
ko05322	Systemic lupus erythematosus	6/1219	151/7206	1.4764401118e-06
ko04924	Renin secretion	33/1219	86/7206	1.5954773229e-06
ko04120	Ubiquitin mediated proteolysis	5/1219	138/7206	1.70015008711e-06
ko04925	Aldosterone synthesis and secretion	38/1219	105/7206	2.13113652548e-06
ko04621	NOD-like receptor signaling pathway	7/1219	157/7206	2.50864687037e-06
ko05164	Influenza A	8/1219	167/7206	2.91806793891e-06
ko04966	Collecting duct acid secretion	15/1219	26/7206	2.94133527885e-06
ko04540	Gap junction	43/1219	128/7206	3.70065623128e-06
ko04730	Long-term depression	30/1219	78/7206	4.67900152752e-06
ko04070	Phosphatidylinositol signaling system	39/1219	112/7206	4.85905902023e-06
ko04060	Cytokine-cytokine receptor interaction	11/1219	191/7206	5.08572618334e-06
ko04976	Bile secretion	30/1219	80/7206	7.98123817107e-06
ko05030	Cocaine addiction	28/1219	73/7206	1.05197586265e-05
ko04010	MAPK signaling pathway	85/1219	321/7206	1.20748400764e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1219	74/7206	1.3585651893e-05
ko04141	Protein processing in endoplasmic reticulum	12/1219	184/7206	3.70183829575e-05
ko04514	Cell adhesion molecules (CAMs)	41/1219	130/7206	4.32042092145e-05
ko04072	Phospholipase D signaling pathway	56/1219	197/7206	4.33231299902e-05
ko04110	Cell cycle	8/1219	145/7206	4.73316024932e-05
ko04064	NF-kappa B signaling pathway	3/1219	96/7206	4.74332805777e-05
ko04972	Pancreatic secretion	36/1219	111/7206	5.50164026653e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1219	79/7206	5.77035798383e-05
ko05414	Dilated cardiomyopathy	36/1219	112/7206	6.31974617079e-05
ko05169	Epstein-Barr virus infection	15/1219	206/7206	6.40234556378e-05
ko04014	Ras signaling pathway	73/1219	279/7206	8.17127940199e-05
ko04964	Proximal tubule bicarbonate reclamation	14/1219	29/7206	9.07224793556e-05
ko04610	Complement and coagulation cascades	2/1219	79/7206	0.000110282736754
ko03008	Ribosome biogenesis in eukaryotes	2/1219	79/7206	0.000110282736754
ko04260	Cardiac muscle contraction	32/1219	98/7206	0.000113315770316
ko04750	Inflammatory mediator regulation of TRP channels	38/1219	122/7206	0.000121880846874
ko04612	Antigen processing and presentation	2/1219	77/7206	0.000167594189789
ko04745	Phototransduction - fly	16/1219	38/7206	0.000218114329516
ko05140	Leishmaniasis	2/1219	75/7206	0.000256239678191
ko04710	Circadian rhythm	17/1219	43/7206	0.00034596923555
ko05110	Vibrio cholerae infection	22/1219	63/7206	0.000515745309656
ko04923	Regulation of lipolysis in adipocytes	25/1219	77/7206	0.00067678445217
ko05161	Hepatitis B	14/1219	173/7206	0.000954493428974
ko04371	Apelin signaling pathway	47/1219	177/7206	0.00106816829974
ko04626	Plant-pathogen interaction	9/1219	18/7206	0.00124347595107
ko04915	Estrogen signaling pathway	37/1219	131/7206	0.00131682422631
ko04922	Glucagon signaling pathway	35/1219	128/7206	0.00272532244239
ko05410	Hypertrophic cardiomyopathy (HCM)	29/1219	100/7206	0.0027446650954
ko05321	Inflammatory bowel disease (IBD)	2/1219	56/7206	0.00376715345997
ko00562	Inositol phosphate metabolism	26/1219	89/7206	0.00392360157553
ko03022	Basal transcription factors	1/1219	44/7206	0.00429553494176
ko05144	Malaria	1/1219	45/7206	0.00433138327646
ko00071	Fatty acid degradation	1/1219	45/7206	0.00433138327646
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1219	59/7206	0.00434630691695
ko05162	Measles	9/1219	120/7206	0.00435611863298
ko03420	Nucleotide excision repair	1/1219	46/7206	0.00454754377721
ko05205	Proteoglycans in cancer	29/1219	271/7206	0.00481679633493
ko05145	Toxoplasmosis	10/1219	126/7206	0.00543133863992
ko00480	Glutathione metabolism	2/1219	55/7206	0.0057233933118
ko04217	Necroptosis	17/1219	178/7206	0.00613093343161
ko04146	Peroxisome	6/1219	89/7206	0.00666199083402
ko00310	Lysine degradation	4/1219	73/7206	0.00681800636576
ko00590	Arachidonic acid metabolism	2/1219	52/7206	0.00821195403368
ko04657	IL-17 signaling pathway	6/1219	87/7206	0.00915100601237
ko05133	Pertussis	6/1219	87/7206	0.00915100601237
ko04930	Type II diabetes mellitus	17/1219	54/7206	0.00923158495841
ko04330	Notch signaling pathway	3/1219	62/7206	0.009444559362
ko04622	RIG-I-like receptor signaling pathway	3/1219	62/7206	0.009444559362
ko03018	RNA degradation	6/1219	84/7206	0.0125230243209
ko04630	Jak-STAT signaling pathway	12/1219	132/7206	0.0134986720226
ko05231	Choline metabolism in cancer	34/1219	134/7206	0.0139064036205
ko00240	Pyrimidine metabolism	9/1219	110/7206	0.0140629056649
ko05131	Shigellosis	6/1219	82/7206	0.0170969376006
ko04916	Melanogenesis	35/1219	142/7206	0.0171725510496
ko04658	Th1 and Th2 cell differentiation	8/1219	96/7206	0.0198565215659
ko04213	Longevity regulating pathway - multiple species	23/1219	86/7206	0.0198599411634
ko04210	Apoptosis	19/1219	180/7206	0.020224574479
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1219	14/7206	0.0203484970695
ko04973	Carbohydrate digestion and absorption	13/1219	42/7206	0.021854147642
ko04015	Rap1 signaling pathway	61/1219	278/7206	0.0272956739218
ko04912	GnRH signaling pathway	30/1219	122/7206	0.0278893748535
ko04510	Focal adhesion	28/1219	240/7206	0.0282058049107
ko05166	HTLV-I infection	36/1219	292/7206	0.0314408289925
ko05214	Glioma	21/1219	79/7206	0.0329273227293
ko00140	Steroid hormone biosynthesis	2/1219	41/7206	0.036053612729
ko05230	Central carbon metabolism in cancer	21/1219	81/7206	0.0362849945025
ko04114	Oocyte meiosis	33/1219	139/7206	0.0388766230332
ko04722	Neurotrophin signaling pathway	37/1219	160/7206	0.0420453285541
ko04115	p53 signaling pathway	6/1219	74/7206	0.0421104784248
ko04350	TGF-beta signaling pathway	10/1219	103/7206	0.0474175058775
ko04668	TNF signaling pathway	12/1219	120/7206	0.0483028721944
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1219	92/7206	0.0486459358618