ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 44/773 152/7206 3.09903870145e-10 ko04713 Circadian entrainment 41/773 136/7206 3.21815160918e-10 ko04080 Neuroactive ligand-receptor interaction 84/773 423/7206 9.29477971559e-09 ko04727 GABAergic synapse 32/773 110/7206 7.46246106361e-08 ko04911 Insulin secretion 33/773 117/7206 1.05875458968e-07 ko04020 Calcium signaling pathway 56/773 265/7206 4.42224722997e-07 ko05031 Amphetamine addiction 27/773 91/7206 5.05884630988e-07 ko04921 Oxytocin signaling pathway 47/773 209/7206 5.84547124855e-07 ko04970 Salivary secretion 27/773 95/7206 1.29834119103e-06 ko04728 Dopaminergic synapse 42/773 185/7206 1.65338513168e-06 ko04725 Cholinergic synapse 38/773 160/7206 1.69050210509e-06 ko04726 Serotonergic synapse 34/773 137/7206 1.97935605486e-06 ko03040 Spliceosome 1/773 145/7206 2.02828868645e-06 ko04971 Gastric acid secretion 27/773 98/7206 2.52030612497e-06 ko05032 Morphine addiction 29/773 110/7206 2.86562177207e-06 ko04720 Long-term potentiation 27/773 99/7206 3.11961808431e-06 ko03010 Ribosome 1/773 129/7206 1.01354703829e-05 ko05033 Nicotine addiction 18/773 56/7206 1.19124280878e-05 ko04022 cGMP-PKG signaling pathway 44/773 216/7206 2.62967192709e-05 ko04925 Aldosterone synthesis and secretion 26/773 105/7206 3.70846401532e-05 ko04730 Long-term depression 21/773 78/7206 4.75689136669e-05 ko04745 Phototransduction - fly 13/773 38/7206 9.46940471625e-05 ko03013 RNA transport 4/773 166/7206 0.000104069286068 ko04070 Phosphatidylinositol signaling system 26/773 112/7206 0.000140337508852 ko04922 Glucagon signaling pathway 28/773 128/7206 0.000224481942978 ko05322 Systemic lupus erythematosus 4/773 151/7206 0.000287586949725 ko04710 Circadian rhythm 13/773 43/7206 0.000384711988538 ko04964 Proximal tubule bicarbonate reclamation 10/773 29/7206 0.000567777217547 ko04110 Cell cycle 4/773 145/7206 0.000582851787169 ko04024 cAMP signaling pathway 48/773 279/7206 0.00075085518767 ko04960 Aldosterone-regulated sodium reabsorption 12/773 41/7206 0.000886294449217 ko04966 Collecting duct acid secretion 9/773 26/7206 0.00103774795478 ko04360 Axon guidance 41/773 233/7206 0.00117031468132 ko04972 Pancreatic secretion 23/773 111/7206 0.00167836590123 ko05224 Breast cancer 7/773 174/7206 0.00182874336984 ko05014 Amyotrophic lateral sclerosis (ALS) 17/773 74/7206 0.00196673088865 ko05203 Viral carcinogenesis 15/773 277/7206 0.00208668160034 ko04924 Renin secretion 19/773 86/7206 0.00220342624299 ko04723 Retrograde endocannabinoid signaling 32/773 175/7206 0.002670699975 ko04137 Mitophagy - animal 18/773 82/7206 0.00318570056922 ko04514 Cell adhesion molecules (CAMs) 25/773 130/7206 0.00370144942757 ko04270 Vascular smooth muscle contraction 28/773 154/7206 0.00517255177251 ko04721 Synaptic vesicle cycle 17/773 80/7206 0.00535532628428 ko04261 Adrenergic signaling in cardiomyocytes 35/773 205/7206 0.00557474069565 ko04540 Gap junction 24/773 128/7206 0.00569594153307 ko04371 Apelin signaling pathway 31/773 177/7206 0.00628322217885 ko05110 Vibrio cholerae infection 14/773 63/7206 0.0066950529431 ko04750 Inflammatory mediator regulation of TRP channels 23/773 122/7206 0.00708154959104 ko04626 Plant-pathogen interaction 6/773 18/7206 0.00893522673202 ko05030 Cocaine addiction 15/773 73/7206 0.0119139694901 ko04742 Taste transduction 13/773 61/7206 0.0122207094681 ko04918 Thyroid hormone synthesis 17/773 86/7206 0.0124898880733 ko04014 Ras signaling pathway 43/773 279/7206 0.0133218671167 ko04136 Autophagy - other 8/773 31/7206 0.0141586305087 ko04141 Protein processing in endoplasmic reticulum 10/773 184/7206 0.0154775828453 ko00120 Primary bile acid biosynthesis 6/773 20/7206 0.0154904165672 ko04650 Natural killer cell mediated cytotoxicity 18/773 97/7206 0.0192366713311 ko05169 Epstein-Barr virus infection 12/773 206/7206 0.0215246875428 ko00680 Methane metabolism 8/773 34/7206 0.0244648518132 ko03050 Proteasome 1/773 54/7206 0.0265442333851 ko04919 Thyroid hormone signaling pathway 24/773 143/7206 0.0275726585523 ko04740 Olfactory transduction 15/773 80/7206 0.0277138338223 ko04138 Autophagy - yeast 15/773 81/7206 0.0295356147274 ko05217 Basal cell carcinoma 2/773 68/7206 0.0301832085272 ko04961 Endocrine and other factor-regulated calcium reabsorption 12/773 59/7206 0.0306324562941 ko05167 Kaposi's sarcoma-associated herpesvirus infection 30/773 191/7206 0.0319856570017 ko00230 Purine metabolism 30/773 194/7206 0.0344063634787 ko04062 Chemokine signaling pathway 31/773 201/7206 0.0366220542653 ko00051 Fructose and mannose metabolism 9/773 42/7206 0.0395856134675 ko05200 Pathways in cancer 39/773 492/7206 0.0411677349989 ko03015 mRNA surveillance pathway 4/773 93/7206 0.0420823313613 ko04711 Circadian rhythm - fly 4/773 13/7206 0.0426583504778 ko05016 Huntington's disease 14/773 215/7206 0.0434219565582 ko00592 alpha-Linolenic acid metabolism 5/773 19/7206 0.0455137424244