ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 56/503 191/7206 1.61277589005e-21 ko04380 Osteoclast differentiation 38/503 134/7206 2.1767484315e-14 ko04621 NOD-like receptor signaling pathway 40/503 157/7206 2.20182950013e-13 ko05340 Primary immunodeficiency 16/503 30/7206 1.46878009622e-11 ko05164 Influenza A 38/503 167/7206 3.71957403751e-11 ko05140 Leishmaniasis 24/503 75/7206 9.39093940195e-11 ko04064 NF-kappa B signaling pathway 27/503 96/7206 1.74125041783e-10 ko04650 Natural killer cell mediated cytotoxicity 27/503 97/7206 2.2582834811e-10 ko05162 Measles 30/503 120/7206 4.04091926233e-10 ko04630 Jak-STAT signaling pathway 31/503 132/7206 1.09772881098e-09 ko05321 Inflammatory bowel disease (IBD) 19/503 56/7206 2.8915067151e-09 ko05152 Tuberculosis 37/503 187/7206 4.46391602963e-09 ko05150 Staphylococcus aureus infection 15/503 36/7206 5.24805648827e-09 ko05145 Toxoplasmosis 29/503 126/7206 6.30134932284e-09 ko05330 Allograft rejection 12/503 24/7206 1.46719389229e-08 ko05144 Malaria 16/503 45/7206 2.43797021422e-08 ko04640 Hematopoietic cell lineage 19/503 64/7206 3.50352085475e-08 ko04620 Toll-like receptor signaling pathway 24/503 100/7206 5.55652064755e-08 ko04610 Complement and coagulation cascades 21/503 79/7206 5.71053908445e-08 ko04660 T cell receptor signaling pathway 27/503 124/7206 7.36716831628e-08 ko04217 Necroptosis 33/503 178/7206 1.61088990056e-07 ko04659 Th17 cell differentiation 24/503 106/7206 1.82022316189e-07 ko05168 Herpes simplex infection 33/503 182/7206 2.77178199267e-07 ko05167 Kaposi's sarcoma-associated herpesvirus infection 33/503 191/7206 8.76795863591e-07 ko05133 Pertussis 20/503 87/7206 1.50186717448e-06 ko05320 Autoimmune thyroid disease 11/503 29/7206 1.87382227953e-06 ko05323 Rheumatoid arthritis 20/503 89/7206 2.19752536997e-06 ko04612 Antigen processing and presentation 18/503 77/7206 3.89574725179e-06 ko05310 Asthma 8/503 17/7206 7.38494182451e-06 ko04658 Th1 and Th2 cell differentiation 20/503 96/7206 7.55713009696e-06 ko05332 Graft-versus-host disease 8/503 18/7206 1.24856380143e-05 ko05142 Chagas disease (American trypanosomiasis) 23/503 130/7206 2.74825378256e-05 ko04672 Intestinal immune network for IgA production 11/503 37/7206 2.77130208279e-05 ko00120 Primary bile acid biosynthesis 8/503 20/7206 3.17152834264e-05 ko04310 Wnt signaling pathway 1/503 181/7206 4.43787331025e-05 ko04062 Chemokine signaling pathway 29/503 201/7206 0.000185574011359 ko04668 TNF signaling pathway 20/503 120/7206 0.000212868797946 ko05034 Alcoholism 4/503 238/7206 0.000247773749849 ko04662 B cell receptor signaling pathway 16/503 88/7206 0.00032891091874 ko04728 Dopaminergic synapse 2/503 185/7206 0.000334312762863 ko04723 Retrograde endocannabinoid signaling 2/503 175/7206 0.000463267313647 ko04137 Mitophagy - animal 15/503 82/7206 0.000468821883628 ko03040 Spliceosome 1/503 145/7206 0.000717851074397 ko04622 RIG-I-like receptor signaling pathway 12/503 62/7206 0.00101508503294 ko05132 Salmonella infection 16/503 98/7206 0.00112545933897 ko05161 Hepatitis B 24/503 173/7206 0.00120029634337 ko04390 Hippo signaling pathway 3/503 188/7206 0.00120506828022 ko04940 Type I diabetes mellitus 8/503 32/7206 0.00125545719736 ko05143 African trypanosomiasis 8/503 32/7206 0.00125545719736 ko04623 Cytosolic DNA-sensing pathway 9/503 41/7206 0.00170921009528 ko05224 Breast cancer 3/503 174/7206 0.0023940783095 ko04145 Phagosome 22/503 162/7206 0.00252225163157 ko04916 Melanogenesis 2/503 142/7206 0.00411196338347 ko04210 Apoptosis 23/503 180/7206 0.00435138384016 ko05134 Legionellosis 12/503 74/7206 0.00480603182134 ko04360 Axon guidance 6/503 233/7206 0.00548389262434 ko04972 Pancreatic secretion 1/503 111/7206 0.0070658222804 ko04611 Platelet activation 21/503 163/7206 0.00717668104481 ko04068 FoxO signaling pathway 21/503 167/7206 0.00808507335589 ko00592 alpha-Linolenic acid metabolism 5/503 19/7206 0.00831893159247 ko00590 Arachidonic acid metabolism 9/503 52/7206 0.00906478660055 ko05146 Amoebiasis 14/503 99/7206 0.00918701557108 ko04146 Peroxisome 13/503 89/7206 0.00992314472475 ko04664 Fc epsilon RI signaling pathway 12/503 77/7206 0.0103449905993 ko04110 Cell cycle 3/503 145/7206 0.0129335254758 ko05131 Shigellosis 12/503 82/7206 0.0134992177886 ko04657 IL-17 signaling pathway 12/503 87/7206 0.0188700866308 ko05418 Fluid shear stress and atherosclerosis 20/503 173/7206 0.0227236284054 ko04080 Neuroactive ligand-receptor interaction 18/503 423/7206 0.0231539395773 ko05010 Alzheimer's disease 6/503 202/7206 0.0236128793022 ko05160 Hepatitis C 18/503 153/7206 0.0244734647355 ko00051 Fructose and mannose metabolism 7/503 42/7206 0.0247299742105 ko04713 Circadian entrainment 3/503 136/7206 0.0253053021783 ko04726 Serotonergic synapse 3/503 137/7206 0.0256199686634 ko05202 Transcriptional misregulation in cancer 21/503 188/7206 0.0288100882609 ko04925 Aldosterone synthesis and secretion 2/503 105/7206 0.0331803927869 ko04530 Tight junction 8/503 228/7206 0.0340164822797 ko04012 ErbB signaling pathway 2/503 109/7206 0.0342211090883 ko04020 Calcium signaling pathway 10/503 265/7206 0.0360445197235 ko04933 AGE-RAGE signaling pathway in diabetic complications 16/503 135/7206 0.0380043483729 ko00982 Drug metabolism - cytochrome P450 6/503 37/7206 0.0410797446109 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/503 5/7206 0.0422155263474 ko04550 Signaling pathways regulating pluripotency of stem cells 5/503 165/7206 0.0433019527689 ko04740 Olfactory transduction 1/503 80/7206 0.0433288755735 ko04720 Long-term potentiation 2/503 99/7206 0.0465393849645 ko04912 GnRH signaling pathway 3/503 122/7206 0.0471784388444