ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	207/1249	423/7206	2.99898266542e-54
ko04724	Glutamatergic synapse	91/1249	152/7206	1.37711973659e-32
ko05033	Nicotine addiction	49/1249	56/7206	1.51634413965e-30
ko05032	Morphine addiction	69/1249	110/7206	1.15230705793e-26
ko04713	Circadian entrainment	77/1249	136/7206	1.72996061613e-25
ko04721	Synaptic vesicle cycle	56/1249	80/7206	1.85515812927e-25
ko04727	GABAergic synapse	66/1249	110/7206	5.80741109772e-24
ko04728	Dopaminergic synapse	87/1249	185/7206	2.87792648642e-21
ko04725	Cholinergic synapse	77/1249	160/7206	1.08152338439e-19
ko04024	cAMP signaling pathway	110/1249	279/7206	4.87366893004e-19
ko04723	Retrograde endocannabinoid signaling	77/1249	175/7206	7.38834192579e-17
ko04911	Insulin secretion	58/1249	117/7206	7.27578545045e-16
ko04020	Calcium signaling pathway	100/1249	265/7206	8.32194264513e-16
ko04742	Taste transduction	38/1249	61/7206	4.47193729426e-15
ko04744	Phototransduction	27/1249	36/7206	4.1790669174e-14
ko04921	Oxytocin signaling pathway	80/1249	209/7206	2.7196665188e-13
ko04726	Serotonergic synapse	60/1249	137/7206	2.73267332439e-13
ko04720	Long-term potentiation	47/1249	99/7206	3.1752450582e-12
ko04740	Olfactory transduction	41/1249	80/7206	3.38214246987e-12
ko04261	Adrenergic signaling in cardiomyocytes	76/1249	205/7206	7.11764837822e-12
ko05031	Amphetamine addiction	44/1249	91/7206	7.19827497805e-12
ko03040	Spliceosome	1/1249	145/7206	4.30465857837e-11
ko04970	Salivary secretion	44/1249	95/7206	4.46588255807e-11
ko04360	Axon guidance	77/1249	233/7206	3.20598476379e-09
ko04925	Aldosterone synthesis and secretion	43/1249	105/7206	1.01104741741e-08
ko05030	Cocaine addiction	33/1249	73/7206	2.57416295166e-08
ko05168	Herpes simplex infection	7/1249	182/7206	2.67201561932e-08
ko04060	Cytokine-cytokine receptor interaction	8/1249	191/7206	3.31639133646e-08
ko05203	Viral carcinogenesis	17/1249	277/7206	3.78597344066e-08
ko04966	Collecting duct acid secretion	17/1249	26/7206	6.72402091464e-08
ko04971	Gastric acid secretion	39/1249	98/7206	1.10840872127e-07
ko04022	cGMP-PKG signaling pathway	69/1249	216/7206	1.19196335858e-07
ko03013	RNA transport	7/1249	166/7206	3.78721334745e-07
ko04924	Renin secretion	34/1249	86/7206	8.87251939784e-07
ko05164	Influenza A	8/1249	167/7206	1.32449741198e-06
ko04540	Gap junction	44/1249	128/7206	2.61044255051e-06
ko04621	NOD-like receptor signaling pathway	8/1249	157/7206	5.55752378133e-06
ko04141	Protein processing in endoplasmic reticulum	11/1249	184/7206	6.80430682745e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1249	74/7206	7.1258141039e-06
ko04260	Cardiac muscle contraction	35/1249	98/7206	1.03458605758e-05
ko04514	Cell adhesion molecules (CAMs)	43/1249	130/7206	1.05340291763e-05
ko05322	Systemic lupus erythematosus	8/1249	151/7206	1.64761401348e-05
ko04120	Ubiquitin mediated proteolysis	7/1249	138/7206	2.08108399068e-05
ko05110	Vibrio cholerae infection	25/1249	63/7206	2.7314580363e-05
ko05169	Epstein-Barr virus infection	15/1249	206/7206	3.34217897778e-05
ko05205	Proteoglycans in cancer	23/1249	271/7206	3.72437402134e-05
ko04010	MAPK signaling pathway	84/1249	321/7206	5.70613305796e-05
ko04730	Long-term depression	28/1249	78/7206	6.6888259703e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1249	79/7206	7.02406354714e-05
ko04745	Phototransduction - fly	17/1249	38/7206	7.58451836211e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1249	59/7206	7.60023658099e-05
ko05162	Measles	6/1249	120/7206	7.8071308059e-05
ko04972	Pancreatic secretion	36/1249	111/7206	0.000111005215845
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1249	79/7206	0.000121514698158
ko04976	Bile secretion	28/1249	80/7206	0.000137849953756
ko05140	Leishmaniasis	2/1249	75/7206	0.000160371156534
ko04915	Estrogen signaling pathway	40/1249	131/7206	0.000165399778586
ko04064	NF-kappa B signaling pathway	4/1249	96/7206	0.000184096414262
ko04626	Plant-pathogen interaction	10/1249	18/7206	0.000268367773434
ko04110	Cell cycle	10/1249	145/7206	0.000341728620973
ko05414	Dilated cardiomyopathy	35/1249	112/7206	0.000341944194754
ko00480	Glutathione metabolism	1/1249	55/7206	0.000528836513923
ko04146	Peroxisome	4/1249	89/7206	0.000566041442526
ko04640	Hematopoietic cell lineage	2/1249	64/7206	0.000774162139739
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1249	14/7206	0.000890395240158
ko04371	Apelin signaling pathway	48/1249	177/7206	0.00117817448827
ko00590	Arachidonic acid metabolism	1/1249	52/7206	0.00128715631282
ko00240	Pyrimidine metabolism	7/1249	110/7206	0.00130655757323
ko04070	Phosphatidylinositol signaling system	33/1249	112/7206	0.00145524417044
ko05161	Hepatitis B	15/1249	173/7206	0.00151147927321
ko04014	Ras signaling pathway	69/1249	279/7206	0.0015713105138
ko04750	Inflammatory mediator regulation of TRP channels	35/1249	122/7206	0.00158580429434
ko00260	Glycine, serine and threonine metabolism	1/1249	48/7206	0.00183932111803
ko04964	Proximal tubule bicarbonate reclamation	12/1249	29/7206	0.00199152576266
ko04072	Phospholipase D signaling pathway	51/1249	197/7206	0.00214932436683
ko03420	Nucleotide excision repair	1/1249	46/7206	0.0027879222877
ko01524	Platinum drug resistance	4/1249	76/7206	0.00330398718025
ko03018	RNA degradation	5/1249	84/7206	0.00339015297223
ko05321	Inflammatory bowel disease (IBD)	2/1249	56/7206	0.00379639623835
ko05145	Toxoplasmosis	10/1249	126/7206	0.00402551047427
ko03022	Basal transcription factors	1/1249	44/7206	0.00424764501502
ko04214	Apoptosis - fly	4/1249	72/7206	0.00461637784756
ko04916	Melanogenesis	38/1249	142/7206	0.00479091600776
ko04923	Regulation of lipolysis in adipocytes	23/1249	77/7206	0.00596376450428
ko00330	Arginine and proline metabolism	3/1249	61/7206	0.00616025327364
ko04622	RIG-I-like receptor signaling pathway	3/1249	62/7206	0.00622891306353
ko04658	Th1 and Th2 cell differentiation	7/1249	96/7206	0.00630547409845
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	10/1249	26/7206	0.00858619347463
ko04612	Antigen processing and presentation	5/1249	77/7206	0.00930938777868
ko00630	Glyoxylate and dicarboxylate metabolism	1/1249	38/7206	0.00956186555322
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1249	40/7206	0.00998970981456
ko04630	Jak-STAT signaling pathway	12/1249	132/7206	0.0102276226125
ko04620	Toll-like receptor signaling pathway	8/1249	100/7206	0.0109458055131
ko05131	Shigellosis	6/1249	82/7206	0.012317278992
ko04115	p53 signaling pathway	5/1249	74/7206	0.0128140048231
ko00310	Lysine degradation	5/1249	73/7206	0.0128197102392
ko05418	Fluid shear stress and atherosclerosis	18/1249	173/7206	0.0142692305012
ko05034	Alcoholism	56/1249	238/7206	0.0144047191162
ko00982	Drug metabolism - cytochrome P450	1/1249	37/7206	0.0145604367611
ko04668	TNF signaling pathway	11/1249	120/7206	0.0147065969802
ko04912	GnRH signaling pathway	32/1249	122/7206	0.0150909473676
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1249	100/7206	0.0157530081604
ko05144	Malaria	2/1249	45/7206	0.0169340752037
ko00071	Fatty acid degradation	2/1249	45/7206	0.0169340752037
ko04270	Vascular smooth muscle contraction	38/1249	154/7206	0.0178769256131
ko00600	Sphingolipid metabolism	4/1249	63/7206	0.0182217512619
ko05206	MicroRNAs in cancer	19/1249	177/7206	0.0201947757903
ko04657	IL-17 signaling pathway	7/1249	87/7206	0.0215161054751
ko05133	Pertussis	7/1249	87/7206	0.0215161054751
ko05166	HTLV-I infection	36/1249	292/7206	0.0217920609708
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/1249	182/7206	0.022090039628
ko04015	Rap1 signaling pathway	62/1249	278/7206	0.0290051967752
ko04933	AGE-RAGE signaling pathway in diabetic complications	14/1249	135/7206	0.0290551667629
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1249	15/7206	0.0325535655721
ko01200	Carbon metabolism	13/1249	128/7206	0.0330753903173
ko05222	Small cell lung cancer	8/1249	89/7206	0.0343500287293
ko05120	Epithelial cell signaling in Helicobacter pylori infection	24/1249	92/7206	0.0361998633203
ko04350	TGF-beta signaling pathway	10/1249	103/7206	0.03626929687
ko00380	Tryptophan metabolism	3/1249	50/7206	0.0368669083689
ko04922	Glucagon signaling pathway	31/1249	128/7206	0.044628749228
ko00561	Glycerolipid metabolism	5/1249	63/7206	0.0452680728149
ko04210	Apoptosis	21/1249	180/7206	0.0455270645784
ko04930	Type II diabetes mellitus	15/1249	54/7206	0.0475855968404
ko04140	Autophagy - animal	19/1249	164/7206	0.0476735551085
ko05320	Autoimmune thyroid disease	1/1249	29/7206	0.0479021157841