ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	173/1051	423/7206	9.1314941159e-43
ko04724	Glutamatergic synapse	79/1051	152/7206	5.48161749029e-28
ko04721	Synaptic vesicle cycle	54/1051	80/7206	3.61306610826e-27
ko05033	Nicotine addiction	44/1051	56/7206	7.05674461819e-27
ko05032	Morphine addiction	61/1051	110/7206	8.373401003e-24
ko04713	Circadian entrainment	67/1051	136/7206	3.63255793977e-22
ko04727	GABAergic synapse	59/1051	110/7206	4.60943615475e-22
ko04728	Dopaminergic synapse	80/1051	185/7206	1.14279668959e-21
ko04725	Cholinergic synapse	71/1051	160/7206	4.0759359935e-20
ko04723	Retrograde endocannabinoid signaling	71/1051	175/7206	1.71659760871e-17
ko04024	cAMP signaling pathway	92/1051	279/7206	2.73854254708e-15
ko04911	Insulin secretion	51/1051	117/7206	2.17331380573e-14
ko04726	Serotonergic synapse	56/1051	137/7206	3.30795525658e-14
ko04742	Taste transduction	34/1051	61/7206	6.80821829053e-14
ko04921	Oxytocin signaling pathway	72/1051	209/7206	3.4587531055e-13
ko04261	Adrenergic signaling in cardiomyocytes	68/1051	205/7206	1.21752653901e-11
ko04020	Calcium signaling pathway	80/1051	265/7206	3.25893433648e-11
ko05031	Amphetamine addiction	39/1051	91/7206	4.95422121402e-11
ko04720	Long-term potentiation	39/1051	99/7206	1.01293094086e-09
ko03040	Spliceosome	1/1051	145/7206	3.56836183378e-09
ko04970	Salivary secretion	37/1051	95/7206	3.95981530896e-09
ko04360	Axon guidance	67/1051	233/7206	1.35914955871e-08
ko04744	Phototransduction	19/1051	36/7206	8.08760372665e-08
ko04740	Olfactory transduction	31/1051	80/7206	8.34953523974e-08
ko04971	Gastric acid secretion	35/1051	98/7206	1.36163277592e-07
ko05168	Herpes simplex infection	5/1051	182/7206	1.69330649578e-07
ko04925	Aldosterone synthesis and secretion	36/1051	105/7206	3.49360906587e-07
ko04966	Collecting duct acid secretion	15/1051	26/7206	4.15025029745e-07
ko03013	RNA transport	5/1051	166/7206	1.06121692046e-06
ko04060	Cytokine-cytokine receptor interaction	7/1051	191/7206	1.12795999165e-06
ko04120	Ubiquitin mediated proteolysis	3/1051	138/7206	1.18728963689e-06
ko05203	Viral carcinogenesis	15/1051	277/7206	1.37609940114e-06
ko04260	Cardiac muscle contraction	33/1051	98/7206	1.62388862986e-06
ko05030	Cocaine addiction	27/1051	73/7206	1.67830295766e-06
ko04010	MAPK signaling pathway	78/1051	321/7206	2.2452605509e-06
ko04540	Gap junction	39/1051	128/7206	3.26271862704e-06
ko04022	cGMP-PKG signaling pathway	57/1051	216/7206	4.83398843306e-06
ko05164	Influenza A	6/1051	167/7206	6.04875228237e-06
ko04514	Cell adhesion molecules (CAMs)	39/1051	130/7206	6.61752124204e-06
ko05110	Vibrio cholerae infection	23/1051	63/7206	1.26120564432e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1051	79/7206	3.31351018757e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	25/1051	74/7206	3.33577373811e-05
ko05322	Systemic lupus erythematosus	6/1051	151/7206	3.44904552932e-05
ko04745	Phototransduction - fly	16/1051	38/7206	3.4963778249e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1051	59/7206	4.63994223687e-05
ko04924	Renin secretion	27/1051	86/7206	7.23894948932e-05
ko04730	Long-term depression	25/1051	78/7206	7.2948446147e-05
ko04621	NOD-like receptor signaling pathway	7/1051	157/7206	7.87253636088e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1051	79/7206	8.26517757003e-05
ko04141	Protein processing in endoplasmic reticulum	10/1051	184/7206	0.000118156000657
ko04014	Ras signaling pathway	63/1051	279/7206	0.000257545756382
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1051	14/7206	0.00026383658768
ko04976	Bile secretion	24/1051	80/7206	0.000344271524189
ko05162	Measles	5/1051	120/7206	0.000359253918865
ko04626	Plant-pathogen interaction	9/1051	18/7206	0.000404572470753
ko04972	Pancreatic secretion	30/1051	111/7206	0.000574895029984
ko05169	Epstein-Barr virus infection	14/1051	206/7206	0.000623806261228
ko04750	Inflammatory mediator regulation of TRP channels	32/1051	122/7206	0.00065650044535
ko04612	Antigen processing and presentation	2/1051	77/7206	0.000931511565444
ko00310	Lysine degradation	2/1051	73/7206	0.00135835286868
ko05140	Leishmaniasis	2/1051	75/7206	0.00140310867598
ko00240	Pyrimidine metabolism	5/1051	110/7206	0.00147820927241
ko04915	Estrogen signaling pathway	33/1051	131/7206	0.00156014362714
ko05414	Dilated cardiomyopathy	29/1051	112/7206	0.00164038600935
ko04964	Proximal tubule bicarbonate reclamation	11/1051	29/7206	0.00166814044005
ko04064	NF-kappa B signaling pathway	4/1051	96/7206	0.0019061099954
ko04916	Melanogenesis	34/1051	142/7206	0.00253511675158
ko00480	Glutathione metabolism	1/1051	55/7206	0.00326568133413
ko04371	Apelin signaling pathway	40/1051	177/7206	0.00348864213711
ko04146	Peroxisome	4/1051	89/7206	0.00373904215221
ko00590	Arachidonic acid metabolism	1/1051	52/7206	0.00485306093472
ko05205	Proteoglycans in cancer	24/1051	271/7206	0.00491438842641
ko04110	Cell cycle	10/1051	145/7206	0.00596033851791
ko00561	Glycerolipid metabolism	2/1051	63/7206	0.00624516978926
ko04640	Hematopoietic cell lineage	2/1051	64/7206	0.00646859026116
ko04214	Apoptosis - fly	3/1051	72/7206	0.00699475591239
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1051	92/7206	0.0071003463294
ko03018	RNA degradation	4/1051	84/7206	0.00746306732919
ko03420	Nucleotide excision repair	1/1051	46/7206	0.0107084181195
ko04270	Vascular smooth muscle contraction	34/1051	154/7206	0.0108076357114
ko05321	Inflammatory bowel disease (IBD)	2/1051	56/7206	0.0129612898699
ko04145	Phagosome	35/1051	162/7206	0.0132002938223
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1051	100/7206	0.0142023008738
ko04114	Oocyte meiosis	31/1051	139/7206	0.014488152544
ko03022	Basal transcription factors	1/1051	44/7206	0.0162183933626
ko00280	Valine, leucine and isoleucine degradation	2/1051	54/7206	0.0187998517214
ko04115	p53 signaling pathway	4/1051	74/7206	0.0199806477333
ko01524	Platinum drug resistance	4/1051	76/7206	0.0205542275905
ko04722	Neurotrophin signaling pathway	34/1051	160/7206	0.0226933667555
ko04391	Hippo signaling pathway - fly	21/1051	90/7206	0.0235751205405
ko00140	Steroid hormone biosynthesis	1/1051	41/7206	0.0239287464469
ko04015	Rap1 signaling pathway	54/1051	278/7206	0.0239547917977
ko04072	Phospholipase D signaling pathway	40/1051	197/7206	0.024333803281
ko00983	Drug metabolism - other enzymes	1/1051	42/7206	0.0248989731456
ko05034	Alcoholism	47/1051	238/7206	0.0249433191575
ko05131	Shigellosis	5/1051	82/7206	0.026603271355
ko04912	GnRH signaling pathway	27/1051	122/7206	0.0266827344226
ko00380	Tryptophan metabolism	2/1051	50/7206	0.0269426996332
ko04622	RIG-I-like receptor signaling pathway	3/1051	62/7206	0.0282945616185
ko05145	Toxoplasmosis	10/1051	126/7206	0.0302350203192
ko04930	Type II diabetes mellitus	14/1051	54/7206	0.0303045088952
ko01200	Carbon metabolism	10/1051	128/7206	0.0306461207282
ko05146	Amoebiasis	7/1051	99/7206	0.0309287320911
ko05204	Chemical carcinogenesis	2/1051	48/7206	0.0386747604014
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1051	182/7206	0.0429023465301
ko04070	Phosphatidylinositol signaling system	24/1051	112/7206	0.0431270506987
ko04973	Carbohydrate digestion and absorption	11/1051	42/7206	0.0452396248098
ko04657	IL-17 signaling pathway	6/1051	87/7206	0.0453257683623
ko05323	Rheumatoid arthritis	20/1051	89/7206	0.0475215650114
ko05161	Hepatitis B	16/1051	173/7206	0.0488587483614