ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	175/1038	423/7206	6.42086852496e-45
ko04724	Glutamatergic synapse	88/1038	152/7206	2.1276643673e-36
ko05033	Nicotine addiction	49/1038	56/7206	1.82247679742e-34
ko05032	Morphine addiction	68/1038	110/7206	9.36793277494e-31
ko04727	GABAergic synapse	67/1038	110/7206	9.38616343958e-30
ko04713	Circadian entrainment	70/1038	136/7206	6.70406026143e-25
ko04721	Synaptic vesicle cycle	49/1038	80/7206	3.40499420493e-22
ko04723	Retrograde endocannabinoid signaling	77/1038	175/7206	8.47941372884e-22
ko04728	Dopaminergic synapse	79/1038	185/7206	2.42569303827e-21
ko04725	Cholinergic synapse	68/1038	160/7206	2.25234380293e-18
ko04744	Phototransduction	27/1038	36/7206	3.5986986521e-16
ko04742	Taste transduction	36/1038	61/7206	6.83540680608e-16
ko04024	cAMP signaling pathway	91/1038	279/7206	4.05286297218e-15
ko04726	Serotonergic synapse	57/1038	137/7206	4.34275790308e-15
ko04911	Insulin secretion	51/1038	117/7206	1.29939509847e-14
ko04020	Calcium signaling pathway	83/1038	265/7206	7.58689290661e-13
ko04921	Oxytocin signaling pathway	69/1038	209/7206	4.28706067551e-12
ko04261	Adrenergic signaling in cardiomyocytes	67/1038	205/7206	2.0096040795e-11
ko05031	Amphetamine addiction	38/1038	91/7206	1.53083036887e-10
ko05030	Cocaine addiction	32/1038	73/7206	9.93721750305e-10
ko04720	Long-term potentiation	38/1038	99/7206	2.76477246627e-09
ko03040	Spliceosome	1/1038	145/7206	5.64333324456e-09
ko04970	Salivary secretion	36/1038	95/7206	1.0823877658e-08
ko05203	Viral carcinogenesis	13/1038	277/7206	1.82739730093e-07
ko04060	Cytokine-cytokine receptor interaction	6/1038	191/7206	3.12649493873e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1038	74/7206	4.8447469723e-07
ko04925	Aldosterone synthesis and secretion	35/1038	105/7206	7.50696081045e-07
ko04740	Olfactory transduction	29/1038	80/7206	8.67902445387e-07
ko04072	Phospholipase D signaling pathway	53/1038	197/7206	4.09998553044e-06
ko04010	MAPK signaling pathway	76/1038	321/7206	6.31596352069e-06
ko05322	Systemic lupus erythematosus	5/1038	151/7206	1.01286640283e-05
ko05110	Vibrio cholerae infection	23/1038	63/7206	1.02227488679e-05
ko04971	Gastric acid secretion	31/1038	98/7206	1.37913270204e-05
ko04966	Collecting duct acid secretion	13/1038	26/7206	1.78592317163e-05
ko03013	RNA transport	7/1038	166/7206	2.7548168065e-05
ko04972	Pancreatic secretion	33/1038	111/7206	2.78601500031e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1038	79/7206	2.79218342046e-05
ko04022	cGMP-PKG signaling pathway	54/1038	216/7206	2.91165742918e-05
ko04141	Protein processing in endoplasmic reticulum	9/1038	184/7206	4.41932165756e-05
ko04621	NOD-like receptor signaling pathway	7/1038	157/7206	7.72397738352e-05
ko05164	Influenza A	8/1038	167/7206	8.23339126799e-05
ko05414	Dilated cardiomyopathy	32/1038	112/7206	0.000101907411061
ko04260	Cardiac muscle contraction	29/1038	98/7206	0.000109737402569
ko04610	Complement and coagulation cascades	1/1038	79/7206	0.000132553682707
ko05168	Herpes simplex infection	10/1038	182/7206	0.000164282057274
ko04350	TGF-beta signaling pathway	3/1038	103/7206	0.000182479361571
ko05205	Proteoglycans in cancer	19/1038	271/7206	0.000191240435394
ko04514	Cell adhesion molecules (CAMs)	35/1038	130/7206	0.000197705639102
ko04070	Phosphatidylinositol signaling system	31/1038	112/7206	0.000204292464947
ko04730	Long-term depression	24/1038	78/7206	0.000231781912359
ko04360	Axon guidance	54/1038	233/7206	0.000278917241654
ko04110	Cell cycle	7/1038	145/7206	0.00029681845267
ko04976	Bile secretion	24/1038	80/7206	0.000300020123157
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1038	59/7206	0.000497411612106
ko04540	Gap junction	33/1038	128/7206	0.000549662119099
ko04064	NF-kappa B signaling pathway	3/1038	96/7206	0.000589071977057
ko05169	Epstein-Barr virus infection	14/1038	206/7206	0.000835573156284
ko04612	Antigen processing and presentation	2/1038	77/7206	0.000934647473117
ko04915	Estrogen signaling pathway	33/1038	131/7206	0.000959679410965
ko03008	Ribosome biogenesis in eukaryotes	2/1038	79/7206	0.000976262478653
ko05161	Hepatitis B	11/1038	173/7206	0.00134930679812
ko05140	Leishmaniasis	2/1038	75/7206	0.00137969478016
ko05162	Measles	6/1038	120/7206	0.00149605990518
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1038	14/7206	0.00171173530297
ko04745	Phototransduction - fly	13/1038	38/7206	0.0017396856982
ko04120	Ubiquitin mediated proteolysis	8/1038	138/7206	0.00204438164301
ko03018	RNA degradation	3/1038	84/7206	0.00249484542217
ko05145	Toxoplasmosis	7/1038	126/7206	0.00290755263558
ko00480	Glutathione metabolism	1/1038	55/7206	0.00325441834346
ko04217	Necroptosis	13/1038	178/7206	0.00470976029108
ko00590	Arachidonic acid metabolism	1/1038	52/7206	0.00485245853712
ko04924	Renin secretion	22/1038	86/7206	0.00516437909521
ko00240	Pyrimidine metabolism	6/1038	110/7206	0.00560857208396
ko04750	Inflammatory mediator regulation of TRP channels	29/1038	122/7206	0.00577549551681
ko04711	Circadian rhythm - fly	6/1038	13/7206	0.00610073168343
ko04640	Hematopoietic cell lineage	2/1038	64/7206	0.00633251511272
ko04710	Circadian rhythm	13/1038	43/7206	0.00710398903321
ko04510	Focal adhesion	21/1038	240/7206	0.00881006999186
ko03420	Nucleotide excision repair	1/1038	46/7206	0.0107585158493
ko04630	Jak-STAT signaling pathway	9/1038	132/7206	0.0116232878471
ko04218	Cellular senescence	14/1038	177/7206	0.0121542069015
ko04918	Thyroid hormone synthesis	21/1038	86/7206	0.0125313944614
ko04550	Signaling pathways regulating pluripotency of stem cells	13/1038	165/7206	0.0133204844452
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/1038	182/7206	0.0137748142825
ko04923	Regulation of lipolysis in adipocytes	19/1038	77/7206	0.0140565182197
ko04146	Peroxisome	5/1038	89/7206	0.0143360469443
ko05222	Small cell lung cancer	5/1038	89/7206	0.0143360469443
ko03022	Basal transcription factors	1/1038	44/7206	0.016095156044
ko05144	Malaria	1/1038	45/7206	0.0166102353792
ko00071	Fatty acid degradation	1/1038	45/7206	0.0166102353792
ko04371	Apelin signaling pathway	37/1038	177/7206	0.0167083977503
ko05166	HTLV-I infection	28/1038	292/7206	0.01686145401
ko04140	Autophagy - animal	13/1038	164/7206	0.0174568818327
ko05016	Huntington's disease	19/1038	215/7206	0.0175428517348
ko04210	Apoptosis	15/1038	180/7206	0.0175824314629
ko04658	Th1 and Th2 cell differentiation	6/1038	96/7206	0.018654277297
ko05321	Inflammatory bowel disease (IBD)	2/1038	56/7206	0.01960351204
ko04657	IL-17 signaling pathway	5/1038	87/7206	0.0199087740305
ko05133	Pertussis	5/1038	87/7206	0.0199087740305
ko05410	Hypertrophic cardiomyopathy (HCM)	23/1038	100/7206	0.0206067140479
ko05120	Epithelial cell signaling in Helicobacter pylori infection	21/1038	92/7206	0.0250737375002
ko04137	Mitophagy - animal	5/1038	82/7206	0.0266798108619
ko00310	Lysine degradation	4/1038	73/7206	0.0279923597986
ko05418	Fluid shear stress and atherosclerosis	15/1038	173/7206	0.0280918519189
ko04964	Proximal tubule bicarbonate reclamation	9/1038	29/7206	0.0281510847993
ko04622	RIG-I-like receptor signaling pathway	3/1038	62/7206	0.0281553670678
ko05215	Prostate cancer	8/1038	111/7206	0.0285040455197
ko04115	p53 signaling pathway	4/1038	74/7206	0.0285728094032
ko04930	Type II diabetes mellitus	14/1038	54/7206	0.0293277556351
ko04014	Ras signaling pathway	53/1038	279/7206	0.0295641204536
ko04062	Chemokine signaling pathway	40/1038	201/7206	0.031719915138
ko05202	Transcriptional misregulation in cancer	17/1038	188/7206	0.0347426185002
ko05231	Choline metabolism in cancer	28/1038	134/7206	0.0348494556409
ko00630	Glyoxylate and dicarboxylate metabolism	1/1038	38/7206	0.0351558540175
ko03320	PPAR signaling pathway	4/1038	69/7206	0.0382111292151
ko00260	Glycine, serine and threonine metabolism	2/1038	48/7206	0.0387675762036
ko05219	Bladder cancer	2/1038	48/7206	0.0387675762036
ko04270	Vascular smooth muscle contraction	31/1038	154/7206	0.047967125043
ko05034	Alcoholism	45/1038	238/7206	0.0485582834728
ko01524	Platinum drug resistance	5/1038	76/7206	0.0488541387199