ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 161/934 423/7206 6.50438045201e-42 ko04724 Glutamatergic synapse 73/934 152/7206 1.8770023668e-26 ko05033 Nicotine addiction 41/934 56/7206 4.43442186277e-25 ko04721 Synaptic vesicle cycle 47/934 80/7206 3.13521526878e-22 ko05032 Morphine addiction 54/934 110/7206 2.17624659508e-20 ko04713 Circadian entrainment 61/934 136/7206 2.44322835872e-20 ko04728 Dopaminergic synapse 73/934 185/7206 3.89047049087e-20 ko04727 GABAergic synapse 53/934 110/7206 1.46390777925e-19 ko04723 Retrograde endocannabinoid signaling 68/934 175/7206 2.12649628513e-18 ko04725 Cholinergic synapse 63/934 160/7206 1.84091013658e-17 ko04911 Insulin secretion 49/934 117/7206 4.26333693845e-15 ko04726 Serotonergic synapse 53/934 137/7206 1.70719022567e-14 ko04024 cAMP signaling pathway 84/934 279/7206 1.88157049981e-14 ko04020 Calcium signaling pathway 79/934 265/7206 1.88811759213e-13 ko04921 Oxytocin signaling pathway 66/934 209/7206 1.03312761252e-12 ko05031 Amphetamine addiction 37/934 91/7206 2.98229979421e-11 ko04970 Salivary secretion 37/934 95/7206 1.33020831705e-10 ko04261 Adrenergic signaling in cardiomyocytes 60/934 205/7206 4.68830655848e-10 ko04720 Long-term potentiation 36/934 99/7206 2.1964944296e-09 ko04742 Taste transduction 26/934 61/7206 8.14176328775e-09 ko04925 Aldosterone synthesis and secretion 36/934 105/7206 1.35195003732e-08 ko04744 Phototransduction 18/934 36/7206 8.31762934801e-08 ko04971 Gastric acid secretion 33/934 98/7206 8.94207941246e-08 ko05322 Systemic lupus erythematosus 2/934 151/7206 2.68256665727e-07 ko03010 Ribosome 1/934 129/7206 4.56731858506e-07 ko03040 Spliceosome 2/934 145/7206 5.98186264773e-07 ko04966 Collecting duct acid secretion 14/934 26/7206 7.31724045485e-07 ko05030 Cocaine addiction 25/934 73/7206 2.29812810502e-06 ko04070 Phosphatidylinositol signaling system 33/934 112/7206 2.96469161124e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 25/934 74/7206 3.05091311872e-06 ko05110 Vibrio cholerae infection 22/934 63/7206 6.44864477835e-06 ko04022 cGMP-PKG signaling pathway 52/934 216/7206 6.90796541895e-06 ko04730 Long-term depression 25/934 78/7206 8.8773120242e-06 ko05168 Herpes simplex infection 6/934 182/7206 9.65922808054e-06 ko04120 Ubiquitin mediated proteolysis 3/934 138/7206 1.51877319734e-05 ko04972 Pancreatic secretion 31/934 111/7206 2.17425514668e-05 ko04750 Inflammatory mediator regulation of TRP channels 33/934 122/7206 2.80175428932e-05 ko05203 Viral carcinogenesis 15/934 277/7206 3.56263790134e-05 ko04014 Ras signaling pathway 60/934 279/7206 5.38692618775e-05 ko04010 MAPK signaling pathway 67/934 321/7206 5.58046533476e-05 ko03013 RNA transport 6/934 166/7206 5.60527814245e-05 ko04360 Axon guidance 52/934 233/7206 6.07292222622e-05 ko04060 Cytokine-cytokine receptor interaction 8/934 191/7206 6.7324545476e-05 ko04540 Gap junction 33/934 128/7206 8.2567044404e-05 ko04740 Olfactory transduction 23/934 80/7206 0.000149038281079 ko04621 NOD-like receptor signaling pathway 6/934 157/7206 0.000158613257726 ko04745 Phototransduction - fly 14/934 38/7206 0.000161905022122 ko05164 Influenza A 7/934 167/7206 0.000246125586788 ko04141 Protein processing in endoplasmic reticulum 9/934 184/7206 0.000340202429778 ko04072 Phospholipase D signaling pathway 43/934 197/7206 0.000502506030438 ko04924 Renin secretion 23/934 86/7206 0.000518338582595 ko04514 Cell adhesion molecules (CAMs) 31/934 130/7206 0.000540743163761 ko04626 Plant-pathogen interaction 8/934 18/7206 0.00101745358848 ko04915 Estrogen signaling pathway 30/934 131/7206 0.00145596361808 ko04110 Cell cycle 7/934 145/7206 0.0016375037993 ko04260 Cardiac muscle contraction 24/934 98/7206 0.00201767206295 ko03008 Ribosome biogenesis in eukaryotes 2/934 79/7206 0.0021700704586 ko05162 Measles 5/934 120/7206 0.00223203823815 ko04510 Focal adhesion 16/934 240/7206 0.00228635934346 ko04630 Jak-STAT signaling pathway 6/934 132/7206 0.00230870056634 ko05414 Dilated cardiomyopathy 26/934 112/7206 0.002558384911 ko05169 Epstein-Barr virus infection 13/934 206/7206 0.00298043533886 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 20/934 79/7206 0.0034234685169 ko05205 Proteoglycans in cancer 20/934 271/7206 0.00410033205007 ko05166 HTLV-I infection 22/934 292/7206 0.00422415708551 ko04960 Aldosterone-regulated sodium reabsorption 12/934 41/7206 0.00452852920152 ko04976 Bile secretion 19/934 80/7206 0.00688240575168 ko04214 Apoptosis - fly 2/934 72/7206 0.00696237657706 ko05120 Epithelial cell signaling in Helicobacter pylori infection 21/934 92/7206 0.00754414035536 ko00280 Valine, leucine and isoleucine degradation 1/934 54/7206 0.00769873433701 ko04964 Proximal tubule bicarbonate reclamation 9/934 29/7206 0.00884947664952 ko04710 Circadian rhythm 12/934 43/7206 0.00939432315896 ko04961 Endocrine and other factor-regulated calcium reabsorption 15/934 59/7206 0.00954979948023 ko04270 Vascular smooth muscle contraction 31/934 154/7206 0.0105575866763 ko04610 Complement and coagulation cascades 3/934 79/7206 0.0106350495726 ko00562 Inositol phosphate metabolism 20/934 89/7206 0.0107831042974 ko05016 Huntington's disease 16/934 215/7206 0.0129758061787 ko04015 Rap1 signaling pathway 50/934 278/7206 0.0137736901353 ko05140 Leishmaniasis 3/934 75/7206 0.0149233268959 ko04114 Oocyte meiosis 28/934 139/7206 0.0149723865747 ko04612 Antigen processing and presentation 3/934 77/7206 0.015368348613 ko05161 Hepatitis B 12/934 173/7206 0.0155654024955 ko04146 Peroxisome 4/934 89/7206 0.0157911169925 ko00260 Glycine, serine and threonine metabolism 1/934 48/7206 0.0168193330488 ko05219 Bladder cancer 1/934 48/7206 0.0168193330488 ko04932 Non-alcoholic fatty liver disease (NAFLD) 13/934 182/7206 0.0182046081812 ko00330 Arginine and proline metabolism 2/934 61/7206 0.0199502128068 ko04330 Notch signaling pathway 2/934 62/7206 0.0204408397472 ko04064 NF-kappa B signaling pathway 5/934 96/7206 0.0206635917092 ko00310 Lysine degradation 3/934 73/7206 0.0212266419136 ko04918 Thyroid hormone synthesis 19/934 86/7206 0.021974220002 ko05145 Toxoplasmosis 8/934 126/7206 0.0225364409192 ko05144 Malaria 1/934 45/7206 0.0248152999219 ko00071 Fatty acid degradation 1/934 45/7206 0.0248152999219 ko04923 Regulation of lipolysis in adipocytes 17/934 77/7206 0.0248937641598 ko05323 Rheumatoid arthritis 19/934 89/7206 0.0249853598816 ko03420 Nucleotide excision repair 1/934 46/7206 0.0251484470724 ko00604 Glycosphingolipid biosynthesis - ganglio series 5/934 14/7206 0.0264689553355 ko04922 Glucagon signaling pathway 25/934 128/7206 0.032742393304 ko04210 Apoptosis 14/934 180/7206 0.0328430456368 ko05222 Small cell lung cancer 5/934 89/7206 0.0377805571521 ko05130 Pathogenic Escherichia coli infection 4/934 77/7206 0.0397688670056 ko01524 Platinum drug resistance 4/934 76/7206 0.0397812087181 ko05416 Viral myocarditis 2/934 55/7206 0.041067152716 ko05206 MicroRNAs in cancer 14/934 177/7206 0.0412831974888 ko04217 Necroptosis 14/934 178/7206 0.0413630706863 ko04916 Melanogenesis 27/934 142/7206 0.0421379982172 ko04550 Signaling pathways regulating pluripotency of stem cells 13/934 165/7206 0.0465619523745