ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 100/671 423/7206 1.17156250293e-19 ko05033 Nicotine addiction 27/671 56/7206 4.82486079872e-14 ko04713 Circadian entrainment 39/671 136/7206 6.58527314768e-11 ko04744 Phototransduction 18/671 36/7206 4.04639268339e-10 ko05032 Morphine addiction 33/671 110/7206 5.47949099987e-10 ko04024 cAMP signaling pathway 59/671 279/7206 1.1929875211e-09 ko04727 GABAergic synapse 32/671 110/7206 2.37294084803e-09 ko04724 Glutamatergic synapse 39/671 152/7206 2.39245414628e-09 ko04610 Complement and coagulation cascades 26/671 79/7206 4.31057007826e-09 ko04972 Pancreatic secretion 31/671 111/7206 1.2460548178e-08 ko04721 Synaptic vesicle cycle 25/671 80/7206 2.80695631639e-08 ko04976 Bile secretion 25/671 80/7206 2.80695631639e-08 ko05031 Amphetamine addiction 25/671 91/7206 4.58394714076e-07 ko04725 Cholinergic synapse 36/671 160/7206 5.01804747852e-07 ko04911 Insulin secretion 29/671 117/7206 6.11343510571e-07 ko04020 Calcium signaling pathway 50/671 265/7206 8.28403839092e-07 ko04978 Mineral absorption 15/671 40/7206 1.28937210666e-06 ko04728 Dopaminergic synapse 38/671 185/7206 2.18900826348e-06 ko04723 Retrograde endocannabinoid signaling 36/671 175/7206 4.11238961688e-06 ko04970 Salivary secretion 23/671 95/7206 1.35356758878e-05 ko04974 Protein digestion and absorption 23/671 96/7206 1.62712482946e-05 ko04726 Serotonergic synapse 29/671 137/7206 1.90944814382e-05 ko03013 RNA transport 2/671 166/7206 1.98260725759e-05 ko04742 Taste transduction 17/671 61/7206 2.59405471392e-05 ko04924 Renin secretion 21/671 86/7206 2.77918064003e-05 ko04550 Signaling pathways regulating pluripotency of stem cells 2/671 165/7206 3.04563149195e-05 ko05166 HTLV-I infection 9/671 292/7206 3.35494719978e-05 ko04971 Gastric acid secretion 22/671 98/7206 7.19496257074e-05 ko05169 Epstein-Barr virus infection 5/671 206/7206 0.000129040203874 ko04964 Proximal tubule bicarbonate reclamation 10/671 29/7206 0.000178059838859 ko04921 Oxytocin signaling pathway 36/671 209/7206 0.000242612955458 ko00340 Histidine metabolism 9/671 25/7206 0.000259311612189 ko05016 Huntington's disease 6/671 215/7206 0.000286727362225 ko04120 Ubiquitin mediated proteolysis 2/671 138/7206 0.000287650229523 ko04060 Cytokine-cytokine receptor interaction 5/671 191/7206 0.000354916578825 ko05012 Parkinson's disease 3/671 155/7206 0.00037603504186 ko02010 ABC transporters 11/671 39/7206 0.000619393961205 ko04141 Protein processing in endoplasmic reticulum 5/671 184/7206 0.000704688547759 ko04720 Long-term potentiation 20/671 99/7206 0.00072246929196 ko04614 Renin-angiotensin system 7/671 18/7206 0.000748838950723 ko04110 Cell cycle 3/671 145/7206 0.000758209057153 ko05030 Cocaine addiction 16/671 73/7206 0.00089869329467 ko04975 Fat digestion and absorption 10/671 35/7206 0.000975661179018 ko00950 Isoquinoline alkaloid biosynthesis 5/671 10/7206 0.0011677041385 ko00983 Drug metabolism - other enzymes 11/671 42/7206 0.00122172792569 ko00830 Retinol metabolism 11/671 42/7206 0.00122172792569 ko05162 Measles 2/671 120/7206 0.0012591309856 ko04740 Olfactory transduction 17/671 80/7206 0.00129520454223 ko05014 Amyotrophic lateral sclerosis (ALS) 16/671 74/7206 0.00174500498409 ko04925 Aldosterone synthesis and secretion 20/671 105/7206 0.00181962931444 ko04022 cGMP-PKG signaling pathway 34/671 216/7206 0.00189840271699 ko05203 Viral carcinogenesis 12/671 277/7206 0.00211317576867 ko04730 Long-term depression 16/671 78/7206 0.00235729637412 ko05164 Influenza A 5/671 167/7206 0.0026598473393 ko04977 Vitamin digestion and absorption 7/671 22/7206 0.00288378367952 ko00290 Valine, leucine and isoleucine biosynthesis 3/671 4/7206 0.00299276415516 ko00360 Phenylalanine metabolism 6/671 17/7206 0.00321755170114 ko04660 T cell receptor signaling pathway 3/671 124/7206 0.00441560720742 ko04390 Hippo signaling pathway 7/671 188/7206 0.00482617280719 ko00380 Tryptophan metabolism 11/671 50/7206 0.00537105512966 ko05168 Herpes simplex infection 7/671 182/7206 0.00647880699571 ko00604 Glycosphingolipid biosynthesis - ganglio series 5/671 14/7206 0.00676573941623 ko04745 Phototransduction - fly 9/671 38/7206 0.0068933959883 ko00232 Caffeine metabolism 3/671 5/7206 0.00696404804675 ko04966 Collecting duct acid secretion 7/671 26/7206 0.00801107040802 ko00350 Tyrosine metabolism 8/671 33/7206 0.00920209952727 ko04961 Endocrine and other factor-regulated calcium reabsorption 12/671 59/7206 0.010270437804 ko03015 mRNA surveillance pathway 2/671 93/7206 0.0109805986942 ko04750 Inflammatory mediator regulation of TRP channels 20/671 122/7206 0.0110975659881 ko00260 Glycine, serine and threonine metabolism 10/671 48/7206 0.0115266945449 ko05161 Hepatitis B 7/671 173/7206 0.011590856033 ko05206 MicroRNAs in cancer 7/671 177/7206 0.0119639623758 ko04621 NOD-like receptor signaling pathway 6/671 157/7206 0.0121243025321 ko04973 Carbohydrate digestion and absorption 9/671 42/7206 0.0134935225563 ko04261 Adrenergic signaling in cardiomyocytes 30/671 205/7206 0.0139183609953 ko00230 Purine metabolism 28/671 194/7206 0.0170013492819 ko05217 Basal cell carcinoma 1/671 68/7206 0.0191406820725 ko04932 Non-alcoholic fatty liver disease (NAFLD) 8/671 182/7206 0.019175748753 ko04626 Plant-pathogen interaction 5/671 18/7206 0.0211914229112 ko00250 Alanine, aspartate and glutamate metabolism 8/671 38/7206 0.0214615886357 ko04630 Jak-STAT signaling pathway 5/671 132/7206 0.0228407911175 ko05200 Pathways in cancer 32/671 492/7206 0.0243812435444 ko04218 Cellular senescence 8/671 177/7206 0.0250622800879 ko04330 Notch signaling pathway 1/671 62/7206 0.0276422588623 ko04923 Regulation of lipolysis in adipocytes 13/671 77/7206 0.0290661734792 ko04510 Focal adhesion 13/671 240/7206 0.0317104905632 ko05215 Prostate cancer 4/671 111/7206 0.0320154645852 ko00120 Primary bile acid biosynthesis 5/671 20/7206 0.0328501782493 ko05224 Breast cancer 8/671 174/7206 0.0332043389455 ko00770 Pantothenate and CoA biosynthesis 4/671 14/7206 0.034992831946 ko04144 Endocytosis 21/671 342/7206 0.036024836697 ko04150 mTOR signaling pathway 9/671 184/7206 0.0385796940391 ko00410 beta-Alanine metabolism 7/671 35/7206 0.0394898530413 ko05145 Toxoplasmosis 5/671 126/7206 0.042235784986 ko04540 Gap junction 19/671 128/7206 0.0437810756857 ko04111 Cell cycle - yeast 3/671 90/7206 0.0447758307308 ko04612 Antigen processing and presentation 2/671 77/7206 0.0453547795146 ko00965 Betalain biosynthesis 2/671 4/7206 0.0457449115194 ko05322 Systemic lupus erythematosus 7/671 151/7206 0.0465183576739 ko04217 Necroptosis 9/671 178/7206 0.0492468519376