ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 44/266 423/7206 2.0983472955e-10 ko04972 Pancreatic secretion 21/266 111/7206 4.37359202121e-10 ko04020 Calcium signaling pathway 28/266 265/7206 4.02841647281e-07 ko00380 Tryptophan metabolism 11/266 50/7206 1.46429153871e-06 ko04024 cAMP signaling pathway 27/266 279/7206 3.66085253973e-06 ko04713 Circadian entrainment 17/266 136/7206 9.32912173703e-06 ko05031 Amphetamine addiction 13/266 91/7206 2.56721363864e-05 ko04975 Fat digestion and absorption 8/266 35/7206 3.06641067511e-05 ko04970 Salivary secretion 13/266 95/7206 4.09497268768e-05 ko04921 Oxytocin signaling pathway 20/266 209/7206 8.23864597292e-05 ko00590 Arachidonic acid metabolism 9/266 52/7206 0.000101445308638 ko00983 Drug metabolism - other enzymes 8/266 42/7206 0.000122865824234 ko04976 Bile secretion 11/266 80/7206 0.000153663188318 ko05030 Cocaine addiction 10/266 73/7206 0.00031569006591 ko04724 Glutamatergic synapse 15/266 152/7206 0.000462730729211 ko00592 alpha-Linolenic acid metabolism 5/266 19/7206 0.000501336487436 ko04750 Inflammatory mediator regulation of TRP channels 13/266 122/7206 0.000529798641855 ko04270 Vascular smooth muscle contraction 15/266 154/7206 0.000532042223818 ko04720 Long-term potentiation 11/266 99/7206 0.000994870552735 ko00591 Linoleic acid metabolism 5/266 22/7206 0.00103675954406 ko04911 Insulin secretion 12/266 117/7206 0.001210971496 ko04726 Serotonergic synapse 13/266 137/7206 0.00157591637752 ko00340 Histidine metabolism 5/266 25/7206 0.00191048694086 ko00561 Glycerolipid metabolism 8/266 63/7206 0.0020640360576 ko04730 Long-term depression 9/266 78/7206 0.00217841013242 ko00650 Butanoate metabolism 5/266 26/7206 0.00229510807021 ko00250 Alanine, aspartate and glutamate metabolism 6/266 38/7206 0.00244053048113 ko04974 Protein digestion and absorption 10/266 96/7206 0.00272359364284 ko04022 cGMP-PKG signaling pathway 17/266 216/7206 0.00280127916035 ko00360 Phenylalanine metabolism 4/266 17/7206 0.00295313770117 ko04971 Gastric acid secretion 10/266 98/7206 0.00317065767328 ko00564 Glycerophospholipid metabolism 10/266 99/7206 0.00341512813626 ko04728 Dopaminergic synapse 15/266 185/7206 0.00425113318243 ko04924 Renin secretion 9/266 86/7206 0.00425326688043 ko05033 Nicotine addiction 7/266 56/7206 0.00425670188539 ko00950 Isoquinoline alkaloid biosynthesis 3/266 10/7206 0.00492105650829 ko04925 Aldosterone synthesis and secretion 10/266 105/7206 0.00521381485333 ko04151 PI3K-Akt signaling pathway 5/266 390/7206 0.00546318395444 ko00350 Tyrosine metabolism 5/266 33/7206 0.00671047431066 ko04742 Taste transduction 7/266 61/7206 0.0068512584023 ko04540 Gap junction 11/266 128/7206 0.00750285936876 ko00680 Methane metabolism 5/266 34/7206 0.00763552471301 ko00290 Valine, leucine and isoleucine biosynthesis 2/266 4/7206 0.00775353124065 ko00965 Betalain biosynthesis 2/266 4/7206 0.00775353124065 ko00260 Glycine, serine and threonine metabolism 6/266 48/7206 0.00797980986781 ko05166 HTLV-I infection 3/266 292/7206 0.0100840845949 ko01040 Biosynthesis of unsaturated fatty acids 4/266 25/7206 0.0124523355283 ko03320 PPAR signaling pathway 7/266 69/7206 0.0132150864831 ko00770 Pantothenate and CoA biosynthesis 3/266 14/7206 0.0133812860169 ko00430 Taurine and hypotaurine metabolism 3/266 14/7206 0.0133812860169 ko02010 ABC transporters 5/266 39/7206 0.0136098215199 ko04918 Thyroid hormone synthesis 8/266 86/7206 0.0136837919644 ko04217 Necroptosis 1/266 178/7206 0.0150739924771 ko04978 Mineral absorption 5/266 40/7206 0.0150982922862 ko04141 Protein processing in endoplasmic reticulum 1/266 184/7206 0.0153896349753 ko04390 Hippo signaling pathway 1/266 188/7206 0.0160343622946 ko04146 Peroxisome 8/266 89/7206 0.0165788434433 ko04725 Cholinergic synapse 12/266 160/7206 0.01731059995 ko00565 Ether lipid metabolism 5/266 42/7206 0.0183934881369 ko00362 Benzoate degradation 2/266 6/7206 0.0184552950282 ko05134 Legionellosis 7/266 74/7206 0.0188839697897 ko05032 Morphine addiction 9/266 110/7206 0.0200386593823 ko04070 Phosphatidylinositol signaling system 9/266 112/7206 0.0222611801299 ko01212 Fatty acid metabolism 6/266 60/7206 0.0225911767797 ko04261 Adrenergic signaling in cardiomyocytes 14/266 205/7206 0.0228500757638 ko04144 Endocytosis 5/266 342/7206 0.0258115587915 ko04610 Complement and coagulation cascades 7/266 79/7206 0.0260732431173 ko04626 Plant-pathogen interaction 3/266 18/7206 0.0269138716821 ko04922 Glucagon signaling pathway 10/266 128/7206 0.0274039492991 ko04915 Estrogen signaling pathway 10/266 131/7206 0.0296168822639 ko05410 Hypertrophic cardiomyopathy (HCM) 8/266 100/7206 0.0309852673839 ko04550 Signaling pathways regulating pluripotency of stem cells 1/266 165/7206 0.0327755237535 ko00901 Indole alkaloid biosynthesis 1/266 1/7206 0.036913683042 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/266 1/7206 0.036913683042 ko01230 Biosynthesis of amino acids 7/266 85/7206 0.0369260522239 ko04723 Retrograde endocannabinoid signaling 12/266 175/7206 0.0382509875057 ko00410 beta-Alanine metabolism 4/266 35/7206 0.038727767525 ko00100 Steroid biosynthesis 3/266 21/7206 0.0404625867177 ko04977 Vitamin digestion and absorption 3/266 22/7206 0.0456116999469 ko00982 Drug metabolism - cytochrome P450 4/266 37/7206 0.0461584322573 ko05200 Pathways in cancer 10/266 492/7206 0.0463029022764 ko05203 Viral carcinogenesis 4/266 277/7206 0.0485449210595 ko04060 Cytokine-cytokine receptor interaction 2/266 191/7206 0.0493336729983