ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 29/135 423/7206 6.2225705329e-10 ko04724 Glutamatergic synapse 16/135 152/7206 1.86062315698e-08 ko04020 Calcium signaling pathway 19/135 265/7206 4.11193936947e-07 ko05033 Nicotine addiction 9/135 56/7206 7.81957599104e-07 ko04720 Long-term potentiation 11/135 99/7206 2.05309149723e-06 ko05031 Amphetamine addiction 9/135 91/7206 4.64865606768e-05 ko04730 Long-term depression 8/135 78/7206 9.59450919549e-05 ko04261 Adrenergic signaling in cardiomyocytes 13/135 205/7206 0.000112642681309 ko04728 Dopaminergic synapse 12/135 185/7206 0.000168784410467 ko05030 Cocaine addiction 7/135 73/7206 0.000403455485136 ko04723 Retrograde endocannabinoid signaling 11/135 175/7206 0.000416453755657 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 7/135 79/7206 0.000654001143192 ko04742 Taste transduction 6/135 61/7206 0.000922350269971 ko04010 MAPK signaling pathway 15/135 321/7206 0.000932301979283 ko04727 GABAergic synapse 8/135 110/7206 0.00101549386162 ko04921 Oxytocin signaling pathway 11/135 209/7206 0.00180442507752 ko00512 Mucin type O-glycan biosynthesis 4/135 29/7206 0.00194524687684 ko04260 Cardiac muscle contraction 7/135 98/7206 0.00232632838044 ko05410 Hypertrophic cardiomyopathy (HCM) 7/135 100/7206 0.00260992317797 ko04713 Circadian entrainment 8/135 136/7206 0.00388819200241 ko05414 Dilated cardiomyopathy 7/135 112/7206 0.00490936921197 ko04024 cAMP signaling pathway 12/135 279/7206 0.00592912202999 ko04072 Phospholipase D signaling pathway 9/135 197/7206 0.011462602459 ko04726 Serotonergic synapse 7/135 137/7206 0.0142022385087 ko04740 Olfactory transduction 5/135 80/7206 0.0167899593872 ko05032 Morphine addiction 6/135 110/7206 0.0169233319467 ko04070 Phosphatidylinositol signaling system 6/135 112/7206 0.0183429543422 ko04022 cGMP-PKG signaling pathway 9/135 216/7206 0.0198481462635 ko04014 Ras signaling pathway 11/135 279/7206 0.0199075458634 ko04970 Salivary secretion 5/135 95/7206 0.0324717174714 ko04915 Estrogen signaling pathway 6/135 131/7206 0.0360472441376 ko05231 Choline metabolism in cancer 6/135 134/7206 0.039589582998 ko05034 Alcoholism 9/135 238/7206 0.0445807465764 ko04925 Aldosterone synthesis and secretion 5/135 105/7206 0.046772166725 ko05014 Amyotrophic lateral sclerosis (ALS) 4/135 74/7206 0.0495827733176