ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 39/103 423/7206 2.10678996103e-22 ko04724 Glutamatergic synapse 16/103 152/7206 3.22996237701e-10 ko04020 Calcium signaling pathway 17/103 265/7206 1.64950461382e-07 ko04726 Serotonergic synapse 12/103 137/7206 4.80491719692e-07 ko04022 cGMP-PKG signaling pathway 13/103 216/7206 1.08485514502e-05 ko04742 Taste transduction 7/103 61/7206 2.30056463986e-05 ko04024 cAMP signaling pathway 14/103 279/7206 3.80544547677e-05 ko04750 Inflammatory mediator regulation of TRP channels 9/103 122/7206 5.60278383658e-05 ko05014 Amyotrophic lateral sclerosis (ALS) 7/103 74/7206 8.15268070703e-05 ko04713 Circadian entrainment 9/103 136/7206 0.000130323884698 ko04727 GABAergic synapse 8/103 110/7206 0.000163104065565 ko04540 Gap junction 8/103 128/7206 0.000460730028468 ko04971 Gastric acid secretion 7/103 98/7206 0.000473769818325 ko04072 Phospholipase D signaling pathway 10/103 197/7206 0.000480031609338 ko04720 Long-term potentiation 7/103 99/7206 0.00050391608187 ko04921 Oxytocin signaling pathway 10/103 209/7206 0.000762602922479 ko05032 Morphine addiction 7/103 110/7206 0.000947745653374 ko04911 Insulin secretion 7/103 117/7206 0.00136166415183 ko05031 Amphetamine addiction 6/103 91/7206 0.00184076064654 ko04725 Cholinergic synapse 8/103 160/7206 0.00197490826354 ko04970 Salivary secretion 6/103 95/7206 0.00229255360695 ko04261 Adrenergic signaling in cardiomyocytes 9/103 205/7206 0.0025456941617 ko04915 Estrogen signaling pathway 7/103 131/7206 0.00260454718586 ko04723 Retrograde endocannabinoid signaling 8/103 175/7206 0.00344680058002 ko04728 Dopaminergic synapse 8/103 185/7206 0.00482633254203 ko04972 Pancreatic secretion 6/103 111/7206 0.00497375695648 ko04924 Renin secretion 5/103 86/7206 0.00755069988822 ko05033 Nicotine addiction 4/103 56/7206 0.00818473375295 ko04071 Sphingolipid signaling pathway 7/103 162/7206 0.00830615639524 ko04650 Natural killer cell mediated cytotoxicity 5/103 97/7206 0.0123586685751 ko04925 Aldosterone synthesis and secretion 5/103 105/7206 0.0169403837585 ko04015 Rap1 signaling pathway 9/103 278/7206 0.0175758411419 ko04014 Ras signaling pathway 9/103 279/7206 0.0179505032768 ko05030 Cocaine addiction 4/103 73/7206 0.0201871147901 ko04270 Vascular smooth muscle contraction 6/103 154/7206 0.0226185163426 ko04370 VEGF signaling pathway 4/103 77/7206 0.0240431184745 ko04626 Plant-pathogen interaction 2/103 18/7206 0.0266736915193 ko04918 Thyroid hormone synthesis 4/103 86/7206 0.0342603085608 ko04922 Glucagon signaling pathway 5/103 128/7206 0.0359829390502 ko04662 B cell receptor signaling pathway 4/103 88/7206 0.0368259832002 ko04114 Oocyte meiosis 5/103 139/7206 0.0484509598929