ko pathway ratio_in_study ratio_in_pop p_value ko04621 NOD-like receptor signaling pathway 30/276 157/7206 1.2788852705e-13 ko04380 Osteoclast differentiation 24/276 134/7206 1.69467202799e-10 ko04060 Cytokine-cytokine receptor interaction 25/276 191/7206 5.67219779708e-08 ko04666 Fc gamma R-mediated phagocytosis 19/276 122/7206 1.51757068964e-07 ko04623 Cytosolic DNA-sensing pathway 11/276 41/7206 2.42104957801e-07 ko04622 RIG-I-like receptor signaling pathway 13/276 62/7206 4.44101318542e-07 ko04620 Toll-like receptor signaling pathway 16/276 100/7206 1.02878247718e-06 ko05131 Shigellosis 14/276 82/7206 2.22338619529e-06 ko04064 NF-kappa B signaling pathway 15/276 96/7206 3.06478297757e-06 ko04217 Necroptosis 21/276 178/7206 3.80102878849e-06 ko04660 T cell receptor signaling pathway 17/276 124/7206 4.29914238139e-06 ko05133 Pertussis 14/276 87/7206 4.60385786301e-06 ko05164 Influenza A 20/276 167/7206 5.16824054805e-06 ko04662 B cell receptor signaling pathway 14/276 88/7206 5.28946320744e-06 ko05161 Hepatitis B 20/276 173/7206 8.87527359642e-06 ko04668 TNF signaling pathway 16/276 120/7206 1.18864166192e-05 ko04630 Jak-STAT signaling pathway 16/276 132/7206 3.98479935203e-05 ko05162 Measles 15/276 120/7206 4.84326493921e-05 ko05132 Salmonella infection 13/276 98/7206 8.34137613808e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 19/276 191/7206 0.000120730099425 ko05168 Herpes simplex infection 18/276 182/7206 0.000196082847505 ko05152 Tuberculosis 18/276 187/7206 0.000275214380123 ko05150 Staphylococcus aureus infection 7/276 36/7206 0.00035976449302 ko05142 Chagas disease (American trypanosomiasis) 14/276 130/7206 0.000424442984861 ko04210 Apoptosis 17/276 180/7206 0.000506755050994 ko05140 Leishmaniasis 10/276 75/7206 0.000528527898976 ko05323 Rheumatoid arthritis 11/276 89/7206 0.000545809499553 ko04659 Th17 cell differentiation 12/276 106/7206 0.00069290451794 ko04144 Endocytosis 26/276 342/7206 0.000734167964645 ko04610 Complement and coagulation cascades 10/276 79/7206 0.00080283747097 ko05340 Primary immunodeficiency 6/276 30/7206 0.000816464140038 ko04062 Chemokine signaling pathway 18/276 201/7206 0.00100930410316 ko00520 Amino sugar and nucleotide sugar metabolism 8/276 55/7206 0.00106415646302 ko04142 Lysosome 14/276 151/7206 0.00186789703681 ko04672 Intestinal immune network for IgA production 6/276 37/7206 0.00255333371521 ko05130 Pathogenic Escherichia coli infection 9/276 77/7206 0.00255841756956 ko04658 Th1 and Th2 cell differentiation 10/276 96/7206 0.00355311548622 ko04650 Natural killer cell mediated cytotoxicity 10/276 97/7206 0.00383117406338 ko05100 Bacterial invasion of epithelial cells 10/276 99/7206 0.00443890736493 ko05321 Inflammatory bowel disease (IBD) 7/276 56/7206 0.00520631913982 ko04611 Platelet activation 14/276 163/7206 0.00538855347803 ko05134 Legionellosis 8/276 74/7206 0.00704747628754 ko04670 Leukocyte transendothelial migration 13/276 151/7206 0.00767559245562 ko05160 Hepatitis C 13/276 153/7206 0.00807252309738 ko05120 Epithelial cell signaling in Helicobacter pylori infection 9/276 92/7206 0.0083787976192 ko05145 Toxoplasmosis 11/276 126/7206 0.00872451692352 ko04664 Fc epsilon RI signaling pathway 8/276 77/7206 0.00891901970421 ko04080 Neuroactive ligand-receptor interaction 7/276 423/7206 0.0125750297823 ko04020 Calcium signaling pathway 3/276 265/7206 0.0136812595332 ko05224 Breast cancer 1/276 174/7206 0.015087594222 ko05016 Huntington's disease 2/276 215/7206 0.0178170121533 ko04550 Signaling pathways regulating pluripotency of stem cells 1/276 165/7206 0.0219150984185 ko04612 Antigen processing and presentation 7/276 77/7206 0.0274596851301 ko05144 Malaria 5/276 45/7206 0.0278039889925 ko05012 Parkinson's disease 1/276 155/7206 0.0316526713763 ko04215 Apoptosis - multiple species 5/276 47/7206 0.0328343359206 ko04145 Phagosome 12/276 162/7206 0.0339772309355 ko00740 Riboflavin metabolism 2/276 8/7206 0.0351305192041 ko00603 Glycosphingolipid biosynthesis - globo and isoglobo series 2/276 8/7206 0.0351305192041 ko05034 Alcoholism 3/276 238/7206 0.0367619906649 ko05169 Epstein-Barr virus infection 14/276 206/7206 0.0391978225932 ko04917 Prolactin signaling pathway 7/276 87/7206 0.048533500559 ko04657 IL-17 signaling pathway 7/276 87/7206 0.048533500559 ko04310 Wnt signaling pathway 2/276 181/7206 0.0489410643582