ko pathway ratio_in_study ratio_in_pop p_value ko04911 Insulin secretion 18/203 117/7206 3.36234636316e-09 ko04725 Cholinergic synapse 20/203 160/7206 1.75966216764e-08 ko04727 GABAergic synapse 16/203 110/7206 5.90246773038e-08 ko04728 Dopaminergic synapse 20/203 185/7206 2.05452390157e-07 ko04713 Circadian entrainment 17/203 136/7206 2.18664450816e-07 ko04721 Synaptic vesicle cycle 13/203 80/7206 2.86977434966e-07 ko04724 Glutamatergic synapse 17/203 152/7206 1.09083220556e-06 ko05032 Morphine addiction 14/203 110/7206 2.14825435657e-06 ko04971 Gastric acid secretion 13/203 98/7206 3.13159104199e-06 ko04024 cAMP signaling pathway 23/203 279/7206 3.15170659331e-06 ko04964 Proximal tubule bicarbonate reclamation 7/203 29/7206 1.16980838094e-05 ko04261 Adrenergic signaling in cardiomyocytes 18/203 205/7206 1.6822540255e-05 ko04921 Oxytocin signaling pathway 17/203 209/7206 7.69704617304e-05 ko04960 Aldosterone-regulated sodium reabsorption 7/203 41/7206 0.000126463762366 ko04925 Aldosterone synthesis and secretion 11/203 105/7206 0.000166017155546 ko05031 Amphetamine addiction 10/203 91/7206 0.000221964787797 ko04961 Endocrine and other factor-regulated calcium reabsorption 8/203 59/7206 0.000222973687714 ko04723 Retrograde endocannabinoid signaling 14/203 175/7206 0.000396403783129 ko04720 Long-term potentiation 10/203 99/7206 0.000442543986209 ko04726 Serotonergic synapse 12/203 137/7206 0.000456578202674 ko04745 Phototransduction - fly 6/203 38/7206 0.000603438061356 ko04966 Collecting duct acid secretion 5/203 26/7206 0.000685446291752 ko04973 Carbohydrate digestion and absorption 6/203 42/7206 0.0010442171093 ko04070 Phosphatidylinositol signaling system 10/203 112/7206 0.00117089572831 ko04970 Salivary secretion 9/203 95/7206 0.0013529523477 ko04626 Plant-pathogen interaction 4/203 18/7206 0.00137160063072 ko04080 Neuroactive ligand-receptor interaction 23/203 423/7206 0.00212156053741 ko04750 Inflammatory mediator regulation of TRP channels 10/203 122/7206 0.00223566250472 ko04540 Gap junction 10/203 128/7206 0.00318075038671 ko04072 Phospholipase D signaling pathway 13/203 197/7206 0.00364122779731 ko04972 Pancreatic secretion 9/203 111/7206 0.00395455916518 ko05214 Glioma 7/203 79/7206 0.00662475613735 ko04066 HIF-1 signaling pathway 9/203 123/7206 0.0077175981722 ko04924 Renin secretion 7/203 86/7206 0.010418169039 ko04918 Thyroid hormone synthesis 7/203 86/7206 0.010418169039 ko04020 Calcium signaling pathway 15/203 265/7206 0.0116907913678 ko00562 Inositol phosphate metabolism 7/203 89/7206 0.0124526958655 ko04015 Rap1 signaling pathway 15/203 278/7206 0.0145122328139 ko04919 Thyroid hormone signaling pathway 9/203 143/7206 0.0193686895933 ko05033 Nicotine addiction 5/203 56/7206 0.0201664750221 ko04260 Cardiac muscle contraction 7/203 98/7206 0.0202606205572 ko00250 Alanine, aspartate and glutamate metabolism 4/203 38/7206 0.0213597528537 ko04360 Axon guidance 13/203 233/7206 0.0233934465674 ko04976 Bile secretion 6/203 80/7206 0.0248323727988 ko04740 Olfactory transduction 6/203 80/7206 0.0248323727988 ko04978 Mineral absorption 4/203 40/7206 0.025325268323 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/203 1/7206 0.0281709686374 ko04915 Estrogen signaling pathway 8/203 131/7206 0.0312869908651 ko05110 Vibrio cholerae infection 5/203 63/7206 0.031733042231 ko05016 Huntington's disease 1/203 215/7206 0.0326309527702 ko04012 ErbB signaling pathway 7/203 109/7206 0.0337893038181 ko04310 Wnt signaling pathway 10/203 181/7206 0.036844107794 ko04014 Ras signaling pathway 14/203 279/7206 0.0387524395578 ko05323 Rheumatoid arthritis 6/203 89/7206 0.0391060851188 ko05152 Tuberculosis 10/203 187/7206 0.0426205032146 ko05120 Epithelial cell signaling in Helicobacter pylori infection 6/203 92/7206 0.0448236532952 ko04722 Neurotrophin signaling pathway 9/203 160/7206 0.0463435410584 ko04071 Sphingolipid signaling pathway 9/203 162/7206 0.0483286381775 ko04145 Phagosome 9/203 162/7206 0.0483286381775