ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 156/953 423/7206 1.94723587017e-37 ko04724 Glutamatergic synapse 77/953 152/7206 3.04955581736e-29 ko05033 Nicotine addiction 43/953 56/7206 2.42444140592e-27 ko04721 Synaptic vesicle cycle 48/953 80/7206 7.47031603388e-23 ko05032 Morphine addiction 56/953 110/7206 1.17115531704e-21 ko04713 Circadian entrainment 62/953 136/7206 1.20606654453e-20 ko04727 GABAergic synapse 53/953 110/7206 3.70461674573e-19 ko04728 Dopaminergic synapse 71/953 185/7206 2.57395231452e-18 ko04723 Retrograde endocannabinoid signaling 68/953 175/7206 6.38819994668e-18 ko04725 Cholinergic synapse 61/953 160/7206 9.97712913947e-16 ko04024 cAMP signaling pathway 84/953 279/7206 4.29193616266e-14 ko04921 Oxytocin signaling pathway 67/953 209/7206 7.76089051035e-13 ko04020 Calcium signaling pathway 78/953 265/7206 1.5740526316e-12 ko04742 Taste transduction 30/953 61/7206 1.11136244812e-11 ko04911 Insulin secretion 44/953 117/7206 1.88458846726e-11 ko04726 Serotonergic synapse 48/953 137/7206 4.31095272651e-11 ko04261 Adrenergic signaling in cardiomyocytes 61/953 205/7206 3.30986211044e-10 ko04720 Long-term potentiation 37/953 99/7206 9.51095324665e-10 ko05031 Amphetamine addiction 34/953 91/7206 4.62565371833e-09 ko04970 Salivary secretion 34/953 95/7206 1.65890011809e-08 ko03040 Spliceosome 1/953 145/7206 3.63161936222e-08 ko04744 Phototransduction 18/953 36/7206 1.13953017817e-07 ko05203 Viral carcinogenesis 11/953 277/7206 2.65732688432e-07 ko04966 Collecting duct acid secretion 14/953 26/7206 9.40026109456e-07 ko04120 Ubiquitin mediated proteolysis 2/953 138/7206 1.33860137224e-06 ko05164 Influenza A 4/953 167/7206 1.35932342151e-06 ko04060 Cytokine-cytokine receptor interaction 6/953 191/7206 2.23531821435e-06 ko04925 Aldosterone synthesis and secretion 32/953 105/7206 3.05256282615e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 25/953 74/7206 4.41432792637e-06 ko04514 Cell adhesion molecules (CAMs) 37/953 130/7206 4.75252608905e-06 ko04971 Gastric acid secretion 30/953 98/7206 5.90425884909e-06 ko05322 Systemic lupus erythematosus 4/953 151/7206 8.98053499395e-06 ko04730 Long-term depression 25/953 78/7206 1.27005107985e-05 ko04010 MAPK signaling pathway 70/953 321/7206 1.44135635229e-05 ko05168 Herpes simplex infection 7/953 182/7206 3.11469508898e-05 ko05030 Cocaine addiction 23/953 73/7206 3.81729917561e-05 ko04745 Phototransduction - fly 15/953 38/7206 4.71176970633e-05 ko04022 cGMP-PKG signaling pathway 50/953 216/7206 5.61649687551e-05 ko04260 Cardiac muscle contraction 28/953 98/7206 5.63174491375e-05 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 24/953 79/7206 6.34170426476e-05 ko04740 Olfactory transduction 24/953 80/7206 7.45380162534e-05 ko04972 Pancreatic secretion 30/953 111/7206 9.39414870582e-05 ko05162 Measles 3/953 120/7206 9.94883973459e-05 ko04360 Axon guidance 52/953 233/7206 0.00010726150979 ko05110 Vibrio cholerae infection 20/953 63/7206 0.000107464789922 ko04621 NOD-like receptor signaling pathway 6/953 157/7206 0.00011027740089 ko03013 RNA transport 7/953 166/7206 0.000168990211334 ko04626 Plant-pathogen interaction 9/953 18/7206 0.000189157409126 ko04141 Protein processing in endoplasmic reticulum 9/953 184/7206 0.000243751565116 ko05169 Epstein-Barr virus infection 11/953 206/7206 0.000335043969247 ko04110 Cell cycle 6/953 145/7206 0.000435623209987 ko05166 HTLV-I infection 20/953 292/7206 0.000546971947341 ko04540 Gap junction 31/953 128/7206 0.000824572344965 ko04915 Estrogen signaling pathway 31/953 131/7206 0.000982277354311 ko04014 Ras signaling pathway 56/953 279/7206 0.00110337896693 ko04064 NF-kappa B signaling pathway 3/953 96/7206 0.00124821086679 ko04072 Phospholipase D signaling pathway 42/953 197/7206 0.00129859693418 ko05205 Proteoglycans in cancer 19/953 271/7206 0.00130371377365 ko05414 Dilated cardiomyopathy 27/953 112/7206 0.00167580616174 ko04610 Complement and coagulation cascades 2/953 79/7206 0.00217885905737 ko03008 Ribosome biogenesis in eukaryotes 2/953 79/7206 0.00217885905737 ko04146 Peroxisome 3/953 89/7206 0.00256505114824 ko04964 Proximal tubule bicarbonate reclamation 10/953 29/7206 0.00290069870359 ko05140 Leishmaniasis 2/953 75/7206 0.0031201177837 ko04612 Antigen processing and presentation 2/953 77/7206 0.00330424616755 ko04976 Bile secretion 20/953 80/7206 0.0040829456165 ko04070 Phosphatidylinositol signaling system 26/953 112/7206 0.00435744655631 ko04214 Apoptosis - fly 2/953 72/7206 0.00453692361621 ko04371 Apelin signaling pathway 37/953 177/7206 0.00461675639387 ko05120 Epithelial cell signaling in Helicobacter pylori infection 22/953 92/7206 0.0047230813735 ko04924 Renin secretion 21/953 86/7206 0.00558473098783 ko05161 Hepatitis B 11/953 173/7206 0.00598434264545 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/953 14/7206 0.00614494081021 ko04510 Focal adhesion 18/953 240/7206 0.00641168808753 ko04750 Inflammatory mediator regulation of TRP channels 27/953 122/7206 0.00642501409256 ko00280 Valine, leucine and isoleucine degradation 1/953 54/7206 0.00765018099934 ko04961 Endocrine and other factor-regulated calcium reabsorption 15/953 59/7206 0.01056176869 ko04330 Notch signaling pathway 2/953 62/7206 0.013635760771 ko00310 Lysine degradation 3/953 73/7206 0.0147998371026 ko01524 Platinum drug resistance 3/953 76/7206 0.0154823839407 ko05410 Hypertrophic cardiomyopathy (HCM) 22/953 100/7206 0.0160924337369 ko04922 Glucagon signaling pathway 26/953 128/7206 0.0241803008006 ko03022 Basal transcription factors 1/953 44/7206 0.0246023291668 ko05144 Malaria 1/953 45/7206 0.0248913859359 ko00071 Fatty acid degradation 1/953 45/7206 0.0248913859359 ko03420 Nucleotide excision repair 1/953 46/7206 0.0256736112328 ko04932 Non-alcoholic fatty liver disease (NAFLD) 14/953 182/7206 0.0259679019451 ko04630 Jak-STAT signaling pathway 9/953 132/7206 0.0268232277193 ko05323 Rheumatoid arthritis 19/953 89/7206 0.0276544055616 ko05321 Inflammatory bowel disease (IBD) 2/953 56/7206 0.0281084695983 ko00480 Glutathione metabolism 2/953 55/7206 0.0281136090257 ko05217 Basal cell carcinoma 3/953 68/7206 0.029320613853 ko04668 TNF signaling pathway 8/953 120/7206 0.0294048098792 ko00240 Pyrimidine metabolism 7/953 110/7206 0.0323087925512 ko05010 Alzheimer's disease 37/953 202/7206 0.0348877489694 ko04978 Mineral absorption 10/953 40/7206 0.0352337408354 ko00140 Steroid hormone biosynthesis 1/953 41/7206 0.0362556660098 ko00680 Methane metabolism 9/953 34/7206 0.0367658421162 ko04657 IL-17 signaling pathway 5/953 87/7206 0.0374519317234 ko00590 Arachidonic acid metabolism 2/953 52/7206 0.0400689211054 ko04114 Oocyte meiosis 27/953 139/7206 0.0417356741122 ko04912 GnRH signaling pathway 24/953 122/7206 0.0421938378106 ko05145 Toxoplasmosis 9/953 126/7206 0.0454210081098 ko04015 Rap1 signaling pathway 48/953 278/7206 0.0468397062202 ko04550 Signaling pathways regulating pluripotency of stem cells 13/953 165/7206 0.0469785466585