ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 50/473 191/7206 3.86066176133e-18 ko05340 Primary immunodeficiency 16/473 30/7206 5.73219892307e-12 ko04380 Osteoclast differentiation 29/473 134/7206 6.93457951682e-09 ko04650 Natural killer cell mediated cytotoxicity 23/473 97/7206 4.3134491916e-08 ko04621 NOD-like receptor signaling pathway 30/473 157/7206 7.76595520263e-08 ko05164 Influenza A 31/473 167/7206 9.40022177963e-08 ko00120 Primary bile acid biosynthesis 10/473 20/7206 1.37440221621e-07 ko05150 Staphylococcus aureus infection 13/473 36/7206 2.03868817555e-07 ko04217 Necroptosis 31/473 178/7206 4.17615545843e-07 ko04640 Hematopoietic cell lineage 17/473 64/7206 4.51887895834e-07 ko05321 Inflammatory bowel disease (IBD) 15/473 56/7206 1.92468708624e-06 ko05162 Measles 23/473 120/7206 2.48577181965e-06 ko04064 NF-kappa B signaling pathway 20/473 96/7206 2.96514799953e-06 ko04612 Antigen processing and presentation 17/473 77/7206 7.23202949932e-06 ko05320 Autoimmune thyroid disease 10/473 29/7206 8.69072401544e-06 ko05168 Herpes simplex infection 29/473 182/7206 9.98967061151e-06 ko05330 Allograft rejection 9/473 24/7206 1.12701340298e-05 ko04659 Th17 cell differentiation 20/473 106/7206 1.44018042381e-05 ko04672 Intestinal immune network for IgA production 11/473 37/7206 1.55333042356e-05 ko05145 Toxoplasmosis 22/473 126/7206 1.96332836836e-05 ko05140 Leishmaniasis 16/473 75/7206 2.12661135124e-05 ko04630 Jak-STAT signaling pathway 22/473 132/7206 4.14467733837e-05 ko04610 Complement and coagulation cascades 16/473 79/7206 4.20055508278e-05 ko05332 Graft-versus-host disease 7/473 18/7206 8.46267847802e-05 ko04310 Wnt signaling pathway 1/473 181/7206 9.96515260999e-05 ko00590 Arachidonic acid metabolism 12/473 52/7206 0.000102444750608 ko04660 T cell receptor signaling pathway 20/473 124/7206 0.000147070133902 ko04662 B cell receptor signaling pathway 16/473 88/7206 0.000162791564738 ko05152 Tuberculosis 26/473 187/7206 0.000238652301275 ko04620 Toll-like receptor signaling pathway 17/473 100/7206 0.000239829712046 ko05133 Pertussis 15/473 87/7206 0.000471459284334 ko04146 Peroxisome 15/473 89/7206 0.000605455245775 ko04062 Chemokine signaling pathway 26/473 201/7206 0.000749615578988 ko05167 Kaposi's sarcoma-associated herpesvirus infection 25/473 191/7206 0.000884895460911 ko00592 alpha-Linolenic acid metabolism 6/473 19/7206 0.00100676318246 ko03040 Spliceosome 1/473 145/7206 0.00101362977095 ko00140 Steroid hormone biosynthesis 9/473 41/7206 0.00110826349187 ko04658 Th1 and Th2 cell differentiation 15/473 96/7206 0.00135826867032 ko05034 Alcoholism 5/473 238/7206 0.00206384151216 ko05144 Malaria 9/473 45/7206 0.0022181827679 ko04390 Hippo signaling pathway 3/473 188/7206 0.00245676150485 ko04666 Fc gamma R-mediated phagocytosis 17/473 122/7206 0.00265973496562 ko03010 Ribosome 1/473 129/7206 0.00328383367372 ko05310 Asthma 5/473 17/7206 0.003812353962 ko04940 Type I diabetes mellitus 7/473 32/7206 0.00401097738107 ko04623 Cytosolic DNA-sensing pathway 8/473 41/7206 0.00452874002826 ko00350 Tyrosine metabolism 7/473 33/7206 0.00480947031895 ko05224 Breast cancer 3/473 174/7206 0.00481110835299 ko03320 PPAR signaling pathway 11/473 69/7206 0.00491818937719 ko00051 Fructose and mannose metabolism 8/473 42/7206 0.00528132630283 ko04110 Cell cycle 2/473 145/7206 0.00595733762634 ko05323 Rheumatoid arthritis 13/473 89/7206 0.00734558802406 ko04916 Melanogenesis 2/473 142/7206 0.00886797176961 ko00982 Drug metabolism - cytochrome P450 7/473 37/7206 0.00923909591591 ko04360 Axon guidance 6/473 233/7206 0.00986163001534 ko04012 ErbB signaling pathway 1/473 109/7206 0.00987522295894 ko04727 GABAergic synapse 1/473 110/7206 0.0100110667293 ko05032 Morphine addiction 1/473 110/7206 0.0100110667293 ko05204 Chemical carcinogenesis 8/473 48/7206 0.0119673792389 ko05161 Hepatitis B 20/473 173/7206 0.0120220016972 ko05160 Hepatitis C 18/473 153/7206 0.0130599924894 ko00980 Metabolism of xenobiotics by cytochrome P450 7/473 40/7206 0.0141245498444 ko04145 Phagosome 19/473 162/7206 0.0144711375983 ko04611 Platelet activation 19/473 163/7206 0.0148396931406 ko00380 Tryptophan metabolism 8/473 50/7206 0.015188378121 ko04723 Retrograde endocannabinoid signaling 4/473 175/7206 0.0189310666489 ko04622 RIG-I-like receptor signaling pathway 9/473 62/7206 0.0189403730687 ko00360 Phenylalanine metabolism 4/473 17/7206 0.0219916448394 ko03050 Proteasome 8/473 54/7206 0.0234397362627 ko00950 Isoquinoline alkaloid biosynthesis 3/473 10/7206 0.0238316766199 ko04550 Signaling pathways regulating pluripotency of stem cells 4/473 165/7206 0.0251300074294 ko04080 Neuroactive ligand-receptor interaction 17/473 423/7206 0.0259868626617 ko04530 Tight junction 7/473 228/7206 0.0286881709097 ko05142 Chagas disease (American trypanosomiasis) 15/473 130/7206 0.02995470174 ko04728 Dopaminergic synapse 5/473 185/7206 0.0333745872678 ko04664 Fc epsilon RI signaling pathway 10/473 77/7206 0.0333881460225 ko04911 Insulin secretion 2/473 117/7206 0.0351221721303 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/473 5/7206 0.0376482342056