ko pathway ratio_in_study ratio_in_pop p_value ko04512 ECM-receptor interaction 21/489 79/7206 3.49622730159e-08 ko04020 Calcium signaling pathway 41/489 265/7206 5.34737048346e-07 ko04922 Glucagon signaling pathway 24/489 128/7206 4.05348982374e-06 ko04974 Protein digestion and absorption 18/489 96/7206 6.50772839622e-05 ko04151 PI3K-Akt signaling pathway 47/489 390/7206 0.000104854474909 ko04510 Focal adhesion 33/489 240/7206 0.000110092228284 ko04933 AGE-RAGE signaling pathway in diabetic complications 21/489 135/7206 0.0003402688338 ko05031 Amphetamine addiction 16/489 91/7206 0.000355471122469 ko00010 Glycolysis / Gluconeogenesis 14/489 74/7206 0.000378807278192 ko04921 Oxytocin signaling pathway 28/489 209/7206 0.000637177282171 ko04745 Phototransduction - fly 9/489 38/7206 0.000782870096412 ko04022 cGMP-PKG signaling pathway 28/489 216/7206 0.000820711064145 ko04713 Circadian entrainment 20/489 136/7206 0.000855812877085 ko05230 Central carbon metabolism in cancer 14/489 81/7206 0.000977329945219 ko00140 Steroid hormone biosynthesis 9/489 41/7206 0.00140239873042 ko00051 Fructose and mannose metabolism 9/489 42/7206 0.00167990200343 ko04710 Circadian rhythm 9/489 43/7206 0.00199973211326 ko03010 Ribosome 1/489 129/7206 0.00216568070996 ko04925 Aldosterone synthesis and secretion 16/489 105/7206 0.00236125835207 ko05322 Systemic lupus erythematosus 2/489 151/7206 0.00287919175244 ko04060 Cytokine-cytokine receptor interaction 24/489 191/7206 0.00310386983259 ko04720 Long-term potentiation 15/489 99/7206 0.00348612939058 ko04152 AMPK signaling pathway 21/489 161/7206 0.00367298196854 ko03040 Spliceosome 2/489 145/7206 0.00411680417197 ko01040 Biosynthesis of unsaturated fatty acids 6/489 25/7206 0.00552582124526 ko04626 Plant-pathogen interaction 5/489 18/7206 0.0057616286391 ko00350 Tyrosine metabolism 7/489 33/7206 0.0057704878696 ko04120 Ubiquitin mediated proteolysis 2/489 138/7206 0.00586922523756 ko03320 PPAR signaling pathway 11/489 69/7206 0.00630216855749 ko00680 Methane metabolism 7/489 34/7206 0.00685208900425 ko04971 Gastric acid secretion 14/489 98/7206 0.00703970401076 ko04924 Renin secretion 13/489 86/7206 0.00725534734922 ko05410 Hypertrophic cardiomyopathy (HCM) 14/489 100/7206 0.00810159357565 ko04270 Vascular smooth muscle contraction 19/489 154/7206 0.00926017256799 ko04066 HIF-1 signaling pathway 16/489 123/7206 0.0103291034033 ko04144 Endocytosis 12/489 342/7206 0.0109314195756 ko04672 Intestinal immune network for IgA production 7/489 37/7206 0.0110001636282 ko05010 Alzheimer's disease 23/489 202/7206 0.0146802028315 ko04725 Cholinergic synapse 19/489 160/7206 0.0158280095727 ko03013 RNA transport 4/489 166/7206 0.0183752840831 ko00030 Pentose phosphate pathway 6/489 32/7206 0.0189127661396 ko04724 Glutamatergic synapse 18/489 152/7206 0.020642514882 ko04610 Complement and coagulation cascades 11/489 79/7206 0.0207510414104 ko00052 Galactose metabolism 6/489 33/7206 0.0218332724221 ko04070 Phosphatidylinositol signaling system 14/489 112/7206 0.0221304352905 ko04371 Apelin signaling pathway 20/489 177/7206 0.0221786040853 ko05146 Amoebiasis 13/489 99/7206 0.023384315733 ko00643 Styrene degradation 2/489 4/7206 0.0251545064841 ko04261 Adrenergic signaling in cardiomyocytes 22/489 205/7206 0.0329286892938 ko00620 Pyruvate metabolism 7/489 46/7206 0.0339001363862 ko00592 alpha-Linolenic acid metabolism 4/489 19/7206 0.0359169143568 ko04728 Dopaminergic synapse 20/489 185/7206 0.0366052881974 ko00561 Glycerolipid metabolism 9/489 63/7206 0.0369917536508 ko00270 Cysteine and methionine metabolism 7/489 47/7206 0.0375998152964 ko04014 Ras signaling pathway 28/489 279/7206 0.0377705248452 ko04650 Natural killer cell mediated cytotoxicity 12/489 97/7206 0.0389883353902 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/489 5/7206 0.0400567702608 ko04730 Long-term depression 10/489 78/7206 0.0411684926667 ko00120 Primary bile acid biosynthesis 4/489 20/7206 0.0425671151431 ko04750 Inflammatory mediator regulation of TRP channels 14/489 122/7206 0.0450704018882 ko04142 Lysosome 4/489 151/7206 0.0470998637238 ko04662 B cell receptor signaling pathway 11/489 88/7206 0.049785593146