ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 43/281 191/7206 8.5860542814e-22 ko04380 Osteoclast differentiation 29/281 134/7206 1.78078180599e-14 ko05140 Leishmaniasis 21/281 75/7206 3.87716636659e-13 ko05164 Influenza A 30/281 167/7206 1.12347497273e-12 ko05340 Primary immunodeficiency 14/281 30/7206 1.13333935813e-12 ko04621 NOD-like receptor signaling pathway 29/281 157/7206 1.3171282091e-12 ko05321 Inflammatory bowel disease (IBD) 18/281 56/7206 1.4138911092e-12 ko05152 Tuberculosis 30/281 187/7206 2.27794131331e-11 ko05145 Toxoplasmosis 24/281 126/7206 6.41695380712e-11 ko05162 Measles 23/281 120/7206 1.4325071891e-10 ko04064 NF-kappa B signaling pathway 20/281 96/7206 5.03439191936e-10 ko05168 Herpes simplex infection 27/281 182/7206 1.47806329004e-09 ko04659 Th17 cell differentiation 20/281 106/7206 3.18139099412e-09 ko04612 Antigen processing and presentation 17/281 77/7206 4.08829639855e-09 ko04650 Natural killer cell mediated cytotoxicity 19/281 97/7206 4.14733916525e-09 ko04630 Jak-STAT signaling pathway 22/281 132/7206 5.81763100067e-09 ko04620 Toll-like receptor signaling pathway 19/281 100/7206 7.06972509328e-09 ko05330 Allograft rejection 10/281 24/7206 8.38417312135e-09 ko04660 T cell receptor signaling pathway 21/281 124/7206 9.73654188704e-09 ko05150 Staphylococcus aureus infection 11/281 36/7206 6.57134037327e-08 ko04217 Necroptosis 24/281 178/7206 8.39442809912e-08 ko05310 Asthma 8/281 17/7206 8.67027411907e-08 ko04672 Intestinal immune network for IgA production 11/281 37/7206 9.03094720518e-08 ko04640 Hematopoietic cell lineage 14/281 64/7206 1.12641421047e-07 ko04658 Th1 and Th2 cell differentiation 17/281 96/7206 1.32797429918e-07 ko05161 Hepatitis B 23/281 173/7206 2.05207231259e-07 ko05320 Autoimmune thyroid disease 9/281 29/7206 9.24360543439e-07 ko05133 Pertussis 15/281 87/7206 1.05703566516e-06 ko05167 Kaposi's sarcoma-associated herpesvirus infection 23/281 191/7206 1.23036185111e-06 ko04623 Cytosolic DNA-sensing pathway 10/281 41/7206 2.65738310507e-06 ko04062 Chemokine signaling pathway 23/281 201/7206 3.00126278913e-06 ko04622 RIG-I-like receptor signaling pathway 12/281 62/7206 3.6845285726e-06 ko04662 B cell receptor signaling pathway 14/281 88/7206 6.51344771032e-06 ko05144 Malaria 10/281 45/7206 6.58418261701e-06 ko04668 TNF signaling pathway 16/281 120/7206 1.48925799598e-05 ko04145 Phagosome 19/281 162/7206 1.56747740784e-05 ko05323 Rheumatoid arthritis 13/281 89/7206 3.5874521532e-05 ko05142 Chagas disease (American trypanosomiasis) 16/281 130/7206 4.09970389112e-05 ko05332 Graft-versus-host disease 6/281 18/7206 4.16316939556e-05 ko05160 Hepatitis C 17/281 153/7206 8.79979223367e-05 ko04664 Fc epsilon RI signaling pathway 11/281 77/7206 0.000175769415582 ko04666 Fc gamma R-mediated phagocytosis 14/281 122/7206 0.000263085601853 ko05132 Salmonella infection 12/281 98/7206 0.000395533828946 ko04657 IL-17 signaling pathway 11/281 87/7206 0.000521396092305 ko04610 Complement and coagulation cascades 10/281 79/7206 0.000921922691454 ko05131 Shigellosis 10/281 82/7206 0.00123527134109 ko04940 Type I diabetes mellitus 6/281 32/7206 0.00128229896003 ko05146 Amoebiasis 11/281 99/7206 0.00155174761726 ko05134 Legionellosis 9/281 74/7206 0.00219012128434 ko05416 Viral myocarditis 7/281 55/7206 0.00518870434058 ko04611 Platelet activation 14/281 163/7206 0.00586630057791 ko04670 Leukocyte transendothelial migration 13/281 151/7206 0.0082247257519 ko05169 Epstein-Barr virus infection 16/281 206/7206 0.00885238189817 ko05034 Alcoholism 2/281 238/7206 0.00926545656419 ko04310 Wnt signaling pathway 1/281 181/7206 0.010411190154 ko05166 HTLV-I infection 20/281 292/7206 0.0127178187327 ko05224 Breast cancer 1/281 174/7206 0.0153288496255 ko04723 Retrograde endocannabinoid signaling 1/281 175/7206 0.0154607905751 ko04210 Apoptosis 14/281 180/7206 0.0164879481633 ko03050 Proteasome 6/281 54/7206 0.0178992607027 ko05418 Fluid shear stress and atherosclerosis 13/281 173/7206 0.0251402817869 ko01524 Platinum drug resistance 7/281 76/7206 0.0280762014931 ko05143 African trypanosomiasis 4/281 32/7206 0.0344841603475 ko04390 Hippo signaling pathway 2/281 188/7206 0.0350152135916 ko04020 Calcium signaling pathway 4/281 265/7206 0.03517101554 ko04514 Cell adhesion molecules (CAMs) 10/281 130/7206 0.0355858241412 ko04360 Axon guidance 3/281 233/7206 0.0365790442239 ko00120 Primary bile acid biosynthesis 3/281 20/7206 0.0409293419572 ko04151 PI3K-Akt signaling pathway 23/281 390/7206 0.0429022220959 ko04916 Melanogenesis 1/281 142/7206 0.0454679231274 ko04110 Cell cycle 1/281 145/7206 0.0465206344196 ko05016 Huntington's disease 3/281 215/7206 0.0491492177096