ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	177/1047	423/7206	9.8742399369e-46
ko05033	Nicotine addiction	50/1047	56/7206	6.2946150013e-36
ko04724	Glutamatergic synapse	87/1047	152/7206	3.69888634184e-35
ko05032	Morphine addiction	68/1047	110/7206	1.61783144633e-30
ko04727	GABAergic synapse	65/1047	110/7206	1.40322663074e-27
ko04728	Dopaminergic synapse	83/1047	185/7206	7.24844682976e-24
ko04713	Circadian entrainment	69/1047	136/7206	7.45503054644e-24
ko04725	Cholinergic synapse	74/1047	160/7206	2.32218962019e-22
ko04723	Retrograde endocannabinoid signaling	77/1047	175/7206	1.46773142881e-21
ko04024	cAMP signaling pathway	101/1047	279/7206	3.0157835079e-20
ko04721	Synaptic vesicle cycle	44/1047	80/7206	2.25568191068e-17
ko04742	Taste transduction	35/1047	61/7206	7.66277478367e-15
ko04726	Serotonergic synapse	56/1047	137/7206	2.79706942787e-14
ko04911	Insulin secretion	49/1047	117/7206	3.95182902844e-13
ko04261	Adrenergic signaling in cardiomyocytes	70/1047	205/7206	9.31135920599e-13
ko04921	Oxytocin signaling pathway	70/1047	209/7206	2.12918655474e-12
ko04360	Axon guidance	74/1047	233/7206	9.72653307803e-12
ko04020	Calcium signaling pathway	81/1047	265/7206	1.41378264393e-11
ko05031	Amphetamine addiction	39/1047	91/7206	4.39936703857e-11
ko04720	Long-term potentiation	39/1047	99/7206	9.03993422048e-10
ko05030	Cocaine addiction	32/1047	73/7206	1.24194713682e-09
ko04744	Phototransduction	21/1047	36/7206	1.33325701479e-09
ko03040	Spliceosome	1/1047	145/7206	5.86554037857e-09
ko04970	Salivary secretion	35/1047	95/7206	5.02245604739e-08
ko04010	MAPK signaling pathway	83/1047	321/7206	5.8347344069e-08
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1047	74/7206	5.80609623847e-07
ko04971	Gastric acid secretion	34/1047	98/7206	6.00065939246e-07
ko04925	Aldosterone synthesis and secretion	35/1047	105/7206	8.98585349419e-07
ko03013	RNA transport	5/1047	166/7206	1.06655470651e-06
ko05203	Viral carcinogenesis	15/1047	277/7206	1.38648144774e-06
ko04022	cGMP-PKG signaling pathway	56/1047	216/7206	7.90916733128e-06
ko05322	Systemic lupus erythematosus	5/1047	151/7206	1.04264769638e-05
ko04730	Long-term depression	27/1047	78/7206	1.11999686402e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1047	79/7206	1.26454687253e-05
ko04514	Cell adhesion molecules (CAMs)	38/1047	130/7206	1.27969199492e-05
ko04060	Cytokine-cytokine receptor interaction	9/1047	191/7206	1.60807300196e-05
ko04072	Phospholipase D signaling pathway	51/1047	197/7206	2.10459984845e-05
ko04972	Pancreatic secretion	33/1047	111/7206	3.15575385432e-05
ko05168	Herpes simplex infection	9/1047	182/7206	4.38114085893e-05
ko04014	Ras signaling pathway	65/1047	279/7206	6.14441523067e-05
ko05164	Influenza A	8/1047	167/7206	8.18026267618e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1047	79/7206	8.33001843601e-05
ko05414	Dilated cardiomyopathy	32/1047	112/7206	0.000110854251738
ko04070	Phosphatidylinositol signaling system	32/1047	112/7206	0.000110854251738
ko04141	Protein processing in endoplasmic reticulum	10/1047	184/7206	0.000118250574516
ko04540	Gap junction	35/1047	128/7206	0.000123380340325
ko04740	Olfactory transduction	25/1047	80/7206	0.000150603232966
ko04120	Ubiquitin mediated proteolysis	6/1047	138/7206	0.000202199961343
ko04915	Estrogen signaling pathway	35/1047	131/7206	0.000230494674871
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1047	59/7206	0.000235796706207
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1047	14/7206	0.000256745902419
ko04260	Cardiac muscle contraction	28/1047	98/7206	0.000257099017857
ko00240	Pyrimidine metabolism	4/1047	110/7206	0.000318318490303
ko04966	Collecting duct acid secretion	11/1047	26/7206	0.000547295532475
ko05205	Proteoglycans in cancer	21/1047	271/7206	0.000782454884293
ko04621	NOD-like receptor signaling pathway	9/1047	157/7206	0.000793031938462
ko04612	Antigen processing and presentation	2/1047	77/7206	0.000930203680616
ko04924	Renin secretion	24/1047	86/7206	0.00105887116542
ko05140	Leishmaniasis	2/1047	75/7206	0.0013927260567
ko03018	RNA degradation	3/1047	84/7206	0.00166650414852
ko04745	Phototransduction - fly	13/1047	38/7206	0.00188501193368
ko01200	Carbon metabolism	7/1047	128/7206	0.00211527758904
ko04371	Apelin signaling pathway	41/1047	177/7206	0.0022856685066
ko04110	Cell cycle	9/1047	145/7206	0.00267470307161
ko04750	Inflammatory mediator regulation of TRP channels	30/1047	122/7206	0.0027075934407
ko04932	Non-alcoholic fatty liver disease (NAFLD)	13/1047	182/7206	0.00271709024797
ko00480	Glutathione metabolism	1/1047	55/7206	0.00325764067238
ko05321	Inflammatory bowel disease (IBD)	1/1047	56/7206	0.00338107058249
ko05110	Vibrio cholerae infection	18/1047	63/7206	0.00344842470963
ko04146	Peroxisome	4/1047	89/7206	0.00374665958046
ko05162	Measles	7/1047	120/7206	0.0038650929743
ko04015	Rap1 signaling pathway	58/1047	278/7206	0.00399710851759
ko04071	Sphingolipid signaling pathway	37/1047	162/7206	0.0044785426954
ko00590	Arachidonic acid metabolism	1/1047	52/7206	0.00484694825245
ko04064	NF-kappa B signaling pathway	5/1047	96/7206	0.0054279166765
ko04640	Hematopoietic cell lineage	2/1047	64/7206	0.00641732091372
ko04923	Regulation of lipolysis in adipocytes	20/1047	77/7206	0.0082428625222
ko00330	Arginine and proline metabolism	2/1047	61/7206	0.00926096165602
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1047	100/7206	0.00987536407415
ko03420	Nucleotide excision repair	1/1047	46/7206	0.0107141649854
ko05034	Alcoholism	49/1047	238/7206	0.0111712824288
ko04976	Bile secretion	20/1047	80/7206	0.0152408898441
ko05169	Epstein-Barr virus infection	18/1047	206/7206	0.015671546253
ko03022	Basal transcription factors	1/1047	44/7206	0.0161676866279
ko05144	Malaria	1/1047	45/7206	0.0168451046753
ko04217	Necroptosis	15/1047	178/7206	0.0174767094339
ko00280	Valine, leucine and isoleucine degradation	2/1047	54/7206	0.0187886618459
ko00515	Mannose type O-glycan biosynthesis	8/1047	25/7206	0.0211475623087
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1047	40/7206	0.0235889717667
ko00983	Drug metabolism - other enzymes	1/1047	42/7206	0.0247494379924
ko04912	GnRH signaling pathway	27/1047	122/7206	0.0264505860259
ko05131	Shigellosis	5/1047	82/7206	0.0265923003771
ko04214	Apoptosis - fly	4/1047	72/7206	0.027761902305
ko04964	Proximal tubule bicarbonate reclamation	9/1047	29/7206	0.0286409997054
ko04918	Thyroid hormone synthesis	20/1047	86/7206	0.029666371716
ko04930	Type II diabetes mellitus	14/1047	54/7206	0.02997958894
ko05016	Huntington's disease	20/1047	215/7206	0.0300004105713
ko00982	Drug metabolism - cytochrome P450	1/1047	37/7206	0.0349174975038
ko04270	Vascular smooth muscle contraction	32/1047	154/7206	0.0364417179914
ko00380	Tryptophan metabolism	2/1047	50/7206	0.0405553646785
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	8/1047	26/7206	0.0435123974832
ko04391	Hippo signaling pathway - fly	20/1047	90/7206	0.04868391272
ko05161	Hepatitis B	16/1047	173/7206	0.0487224565845
ko01524	Platinum drug resistance	5/1047	76/7206	0.0487461815489