ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 56/430 191/7206 5.96911577932e-25 ko04380 Osteoclast differentiation 39/430 134/7206 1.73055179954e-17 ko05321 Inflammatory bowel disease (IBD) 23/430 56/7206 1.98670171033e-14 ko05140 Leishmaniasis 25/430 75/7206 4.09651008392e-13 ko04064 NF-kappa B signaling pathway 28/430 96/7206 6.71416305107e-13 ko05340 Primary immunodeficiency 16/430 30/7206 1.32122456161e-12 ko05164 Influenza A 37/430 167/7206 1.45645812682e-12 ko04659 Th17 cell differentiation 29/430 106/7206 1.55570701836e-12 ko04621 NOD-like receptor signaling pathway 35/430 157/7206 5.00068233262e-12 ko05330 Allograft rejection 14/430 24/7206 6.68490899567e-12 ko05162 Measles 30/430 120/7206 8.04078301173e-12 ko05145 Toxoplasmosis 30/430 126/7206 3.05663313006e-11 ko05150 Staphylococcus aureus infection 16/430 36/7206 4.75492198927e-11 ko05152 Tuberculosis 37/430 187/7206 5.17680687505e-11 ko04630 Jak-STAT signaling pathway 30/430 132/7206 1.0633221177e-10 ko04658 Th1 and Th2 cell differentiation 25/430 96/7206 1.81109657135e-10 ko04650 Natural killer cell mediated cytotoxicity 25/430 97/7206 2.3073134791e-10 ko04640 Hematopoietic cell lineage 20/430 64/7206 3.60864864977e-10 ko05168 Herpes simplex infection 35/430 182/7206 4.01247277972e-10 ko04620 Toll-like receptor signaling pathway 24/430 100/7206 2.56642739774e-09 ko04660 T cell receptor signaling pathway 27/430 124/7206 2.58568550202e-09 ko05320 Autoimmune thyroid disease 13/430 29/7206 2.86983335283e-09 ko04217 Necroptosis 33/430 178/7206 3.45781701093e-09 ko04672 Intestinal immune network for IgA production 14/430 37/7206 1.013404162e-08 ko04612 Antigen processing and presentation 20/430 77/7206 1.31082010953e-08 ko05332 Graft-versus-host disease 10/430 18/7206 1.46737990913e-08 ko04610 Complement and coagulation cascades 20/430 79/7206 2.11112915691e-08 ko05310 Asthma 9/430 17/7206 1.39867858764e-07 ko05144 Malaria 13/430 45/7206 1.27886041402e-06 ko04940 Type I diabetes mellitus 10/430 32/7206 1.01267869318e-05 ko04062 Chemokine signaling pathway 29/430 201/7206 1.07935104678e-05 ko05133 Pertussis 17/430 87/7206 1.14845488105e-05 ko04662 B cell receptor signaling pathway 17/430 88/7206 1.34669380438e-05 ko05323 Rheumatoid arthritis 17/430 89/7206 1.57492757462e-05 ko05142 Chagas disease (American trypanosomiasis) 21/430 130/7206 2.44510438114e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 27/430 191/7206 2.86228820596e-05 ko04622 RIG-I-like receptor signaling pathway 13/430 62/7206 5.72729710506e-05 ko05161 Hepatitis B 24/430 173/7206 0.000106031952234 ko04145 Phagosome 23/430 162/7206 0.000125010910911 ko04611 Platelet activation 22/430 163/7206 0.000289282204779 ko04723 Retrograde endocannabinoid signaling 1/430 175/7206 0.00049865375547 ko04664 Fc epsilon RI signaling pathway 13/430 77/7206 0.000558439757741 ko04668 TNF signaling pathway 17/430 120/7206 0.000711567165041 ko00590 Arachidonic acid metabolism 10/430 52/7206 0.000846742299028 ko04728 Dopaminergic synapse 2/430 185/7206 0.00144088165066 ko05034 Alcoholism 4/430 238/7206 0.00196992434159 ko04310 Wnt signaling pathway 2/430 181/7206 0.00210567594973 ko03040 Spliceosome 1/430 145/7206 0.00220711973151 ko04623 Cytosolic DNA-sensing pathway 8/430 41/7206 0.00251546782549 ko05160 Hepatitis C 19/430 153/7206 0.00260120776054 ko04137 Mitophagy - animal 12/430 82/7206 0.0031978022245 ko04916 Melanogenesis 1/430 142/7206 0.00336279164906 ko04210 Apoptosis 21/430 180/7206 0.00340311543684 ko03050 Proteasome 9/430 54/7206 0.00425216245644 ko05418 Fluid shear stress and atherosclerosis 20/430 173/7206 0.00481574908717 ko00120 Primary bile acid biosynthesis 5/430 20/7206 0.00542764111468 ko04390 Hippo signaling pathway 3/430 188/7206 0.00705808010981 ko03010 Ribosome 1/430 129/7206 0.00717652146097 ko04514 Cell adhesion molecules (CAMs) 16/430 130/7206 0.00733341833518 ko05132 Salmonella infection 13/430 98/7206 0.00753465697262 ko04724 Glutamatergic synapse 2/430 152/7206 0.00858332141693 ko04911 Insulin secretion 1/430 117/7206 0.00991807708816 ko05143 African trypanosomiasis 6/430 32/7206 0.0104914963331 ko05166 HTLV-I infection 28/430 292/7206 0.0112717965623 ko05202 Transcriptional misregulation in cancer 20/430 188/7206 0.0113805017857 ko04727 GABAergic synapse 1/430 110/7206 0.0143907825704 ko05416 Viral myocarditis 8/430 55/7206 0.0154803805346 ko05146 Amoebiasis 12/430 99/7206 0.0165000939027 ko04713 Circadian entrainment 2/430 136/7206 0.0171356676551 ko04666 Fc gamma R-mediated phagocytosis 14/430 122/7206 0.0181086813661 ko04657 IL-17 signaling pathway 11/430 87/7206 0.0184603612229 ko04925 Aldosterone synthesis and secretion 1/430 105/7206 0.0208858961363 ko04670 Leukocyte transendothelial migration 16/430 151/7206 0.0225547606791 ko00592 alpha-Linolenic acid metabolism 4/430 19/7206 0.0236932718812 ko05131 Shigellosis 10/430 82/7206 0.0295903677083 ko04971 Gastric acid secretion 1/430 98/7206 0.0301476917278 ko04072 Phospholipase D signaling pathway 19/430 197/7206 0.03262492919 ko05224 Breast cancer 4/430 174/7206 0.0344171997578 ko05169 Epstein-Barr virus infection 20/430 206/7206 0.0346172222072 ko01200 Carbon metabolism 2/430 128/7206 0.035189617312 ko00051 Fructose and mannose metabolism 6/430 42/7206 0.0368762813769 ko00480 Glutathione metabolism 7/430 55/7206 0.0437357320035 ko04910 Insulin signaling pathway 4/430 172/7206 0.0478746297904 ko04110 Cell cycle 3/430 145/7206 0.048710602466 ko04360 Axon guidance 7/430 233/7206 0.049074406268