ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 36/330 145/7206 1.60084489498e-17 ko04110 Cell cycle 31/330 145/7206 2.60748545492e-13 ko03440 Homologous recombination 17/330 41/7206 6.35511672143e-13 ko03008 Ribosome biogenesis in eukaryotes 22/330 79/7206 3.13557904829e-12 ko04111 Cell cycle - yeast 21/330 90/7206 3.80360943462e-10 ko03460 Fanconi anemia pathway 16/330 51/7206 4.34507033818e-10 ko04080 Neuroactive ligand-receptor interaction 1/330 423/7206 5.33615842801e-08 ko03013 RNA transport 25/330 166/7206 1.1346237136e-07 ko04113 Meiosis - yeast 15/330 70/7206 4.32945103781e-07 ko05322 Systemic lupus erythematosus 22/330 151/7206 1.1963269756e-06 ko03020 RNA polymerase 9/330 29/7206 3.52887760232e-06 ko03022 Basal transcription factors 10/330 44/7206 2.18276604671e-05 ko03018 RNA degradation 14/330 84/7206 2.33352412176e-05 ko03410 Base excision repair 9/330 38/7206 3.98447190151e-05 ko04144 Endocytosis 3/330 342/7206 0.000155382562171 ko05203 Viral carcinogenesis 27/330 277/7206 0.00017863290144 ko04010 MAPK signaling pathway 3/330 321/7206 0.000311848164768 ko04151 PI3K-Akt signaling pathway 5/330 390/7206 0.000412977664821 ko00240 Pyrimidine metabolism 14/330 110/7206 0.000459380414205 ko05034 Alcoholism 23/330 238/7206 0.000682793914797 ko04020 Calcium signaling pathway 2/330 265/7206 0.000761904751617 ko03420 Nucleotide excision repair 8/330 46/7206 0.00100827428185 ko04921 Oxytocin signaling pathway 1/330 209/7206 0.0010975358964 ko05010 Alzheimer's disease 1/330 202/7206 0.00163819593639 ko04114 Oocyte meiosis 15/330 139/7206 0.00165960005696 ko05152 Tuberculosis 1/330 187/7206 0.00229739480452 ko04728 Dopaminergic synapse 1/330 185/7206 0.00350145888582 ko04723 Retrograde endocannabinoid signaling 1/330 175/7206 0.0050073978446 ko04371 Apelin signaling pathway 1/330 177/7206 0.00514667353782 ko04261 Adrenergic signaling in cardiomyocytes 2/330 205/7206 0.00620925600684 ko04115 p53 signaling pathway 9/330 74/7206 0.00634533216918 ko04510 Focal adhesion 3/330 240/7206 0.00702597411345 ko03030 DNA replication 6/330 38/7206 0.00703264915205 ko05205 Proteoglycans in cancer 4/330 271/7206 0.00741704269694 ko04015 Rap1 signaling pathway 4/330 278/7206 0.00760374125701 ko04024 cAMP signaling pathway 4/330 279/7206 0.00767353369961 ko04014 Ras signaling pathway 4/330 279/7206 0.00767353369961 ko04914 Progesterone-mediated oocyte maturation 11/330 104/7206 0.00776527610035 ko04072 Phospholipase D signaling pathway 2/330 197/7206 0.00882321067589 ko03015 mRNA surveillance pathway 10/330 93/7206 0.0097583835717 ko04810 Regulation of actin cytoskeleton 4/330 264/7206 0.0101985477268 ko04724 Glutamatergic synapse 1/330 152/7206 0.0102712977014 ko04725 Cholinergic synapse 1/330 160/7206 0.0108950631644 ko04060 Cytokine-cytokine receptor interaction 2/330 191/7206 0.0126606158513 ko05167 Kaposi's sarcoma-associated herpesvirus infection 2/330 191/7206 0.0126606158513 ko03430 Mismatch repair 4/330 22/7206 0.0164209522451 ko04933 AGE-RAGE signaling pathway in diabetic complications 1/330 135/7206 0.021464353364 ko04713 Circadian entrainment 1/330 136/7206 0.0214822349744 ko01200 Carbon metabolism 1/330 128/7206 0.0310338999472 ko05142 Chagas disease (American trypanosomiasis) 1/330 130/7206 0.0313791056963 ko04915 Estrogen signaling pathway 1/330 131/7206 0.0316459726056 ko05200 Pathways in cancer 13/330 492/7206 0.033060136454 ko04152 AMPK signaling pathway 2/330 161/7206 0.0347679802113 ko04071 Sphingolipid signaling pathway 2/330 162/7206 0.0348557762502 ko04611 Platelet activation 2/330 163/7206 0.0349978810313 ko04530 Tight junction 4/330 228/7206 0.0351358105987 ko04062 Chemokine signaling pathway 3/330 201/7206 0.0371856473072 ko05169 Epstein-Barr virus infection 16/330 206/7206 0.0396153911549 ko05166 HTLV-I infection 21/330 292/7206 0.0433455512614 ko04911 Insulin secretion 1/330 117/7206 0.0444965724537 ko04211 Longevity regulating pathway 1/330 123/7206 0.0458487758579 ko04066 HIF-1 signaling pathway 1/330 123/7206 0.0458487758579 ko04660 T cell receptor signaling pathway 1/330 124/7206 0.0463722011363 ko01522 Endocrine resistance 1/330 124/7206 0.0463722011363 ko04022 cGMP-PKG signaling pathway 4/330 216/7206 0.0472199059561 ko04142 Lysosome 2/330 151/7206 0.0485277113371 ko04122 Sulfur relay system 2/330 8/7206 0.0487532932522 ko05012 Parkinson's disease 2/330 155/7206 0.0491596972665