ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	196/1152	423/7206	1.8177453346e-52
ko04724	Glutamatergic synapse	84/1152	152/7206	2.66777994295e-29
ko05033	Nicotine addiction	45/1152	56/7206	1.73853575381e-26
ko05032	Morphine addiction	64/1152	110/7206	3.09755075582e-24
ko04713	Circadian entrainment	72/1152	136/7206	1.00822207228e-23
ko04728	Dopaminergic synapse	81/1152	185/7206	9.65450036585e-20
ko04721	Synaptic vesicle cycle	48/1152	80/7206	3.01607851973e-19
ko04727	GABAergic synapse	58/1152	110/7206	3.28555415637e-19
ko04020	Calcium signaling pathway	98/1152	265/7206	2.52561646322e-17
ko04024	cAMP signaling pathway	100/1152	279/7206	1.20253012612e-16
ko04725	Cholinergic synapse	69/1152	160/7206	1.49511532816e-16
ko04723	Retrograde endocannabinoid signaling	72/1152	175/7206	6.85183938548e-16
ko04911	Insulin secretion	53/1152	117/7206	4.63191766058e-14
ko04921	Oxytocin signaling pathway	77/1152	209/7206	8.7293679462e-14
ko04742	Taste transduction	34/1152	61/7206	1.05110930532e-12
ko04726	Serotonergic synapse	56/1152	137/7206	1.73272022947e-12
ko05031	Amphetamine addiction	40/1152	91/7206	1.95663817756e-10
ko04720	Long-term potentiation	42/1152	99/7206	2.69781754153e-10
ko04261	Adrenergic signaling in cardiomyocytes	67/1152	205/7206	1.69010959884e-09
ko03040	Spliceosome	2/1152	145/7206	6.47148371212e-09
ko03010	Ribosome	1/1152	129/7206	6.68764142684e-09
ko04970	Salivary secretion	38/1152	95/7206	1.38378603804e-08
ko04740	Olfactory transduction	33/1152	80/7206	5.14085280406e-08
ko04744	Phototransduction	20/1152	36/7206	5.64441785288e-08
ko04925	Aldosterone synthesis and secretion	39/1152	105/7206	1.07941358588e-07
ko04022	cGMP-PKG signaling pathway	65/1152	216/7206	1.31646539758e-07
ko05322	Systemic lupus erythematosus	4/1152	151/7206	2.1499161589e-07
ko03013	RNA transport	6/1152	166/7206	5.34444956871e-07
ko05168	Herpes simplex infection	8/1152	182/7206	1.60436104198e-06
ko04360	Axon guidance	65/1152	233/7206	2.72702148469e-06
ko05164	Influenza A	7/1152	167/7206	2.86699254409e-06
ko05030	Cocaine addiction	28/1152	73/7206	3.00941881646e-06
ko04971	Gastric acid secretion	34/1152	98/7206	4.59056936587e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1152	74/7206	6.46140728549e-06
ko04010	MAPK signaling pathway	82/1152	321/7206	7.4675918948e-06
ko04060	Cytokine-cytokine receptor interaction	10/1152	191/7206	7.80906124951e-06
ko04514	Cell adhesion molecules (CAMs)	41/1152	130/7206	8.7637259083e-06
ko05203	Viral carcinogenesis	20/1152	277/7206	1.21413883439e-05
ko04621	NOD-like receptor signaling pathway	7/1152	157/7206	1.23145161092e-05
ko04540	Gap junction	40/1152	128/7206	1.38131089058e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1152	79/7206	3.32898147282e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1152	79/7206	6.74250924538e-05
ko04745	Phototransduction - fly	16/1152	38/7206	0.000109798281538
ko04730	Long-term depression	26/1152	78/7206	0.000132427711071
ko04120	Ubiquitin mediated proteolysis	7/1152	138/7206	0.00013846809998
ko04141	Protein processing in endoplasmic reticulum	12/1152	184/7206	0.000141380240857
ko04072	Phospholipase D signaling pathway	52/1152	197/7206	0.000155429449239
ko04110	Cell cycle	8/1152	145/7206	0.000203327474312
ko04972	Pancreatic secretion	33/1152	111/7206	0.000218553599891
ko04966	Collecting duct acid secretion	12/1152	26/7206	0.000284516333928
ko04924	Renin secretion	27/1152	86/7206	0.000305330227223
ko05162	Measles	6/1152	120/7206	0.00035814345064
ko05161	Hepatitis B	12/1152	173/7206	0.000477285027893
ko04710	Circadian rhythm	16/1152	43/7206	0.00059305207696
ko05414	Dilated cardiomyopathy	32/1152	112/7206	0.000636224610432
ko04070	Phosphatidylinositol signaling system	32/1152	112/7206	0.000636224610432
ko05169	Epstein-Barr virus infection	16/1152	206/7206	0.000666327729349
ko04260	Cardiac muscle contraction	29/1152	98/7206	0.00069659950205
ko04750	Inflammatory mediator regulation of TRP channels	34/1152	122/7206	0.000699182291219
ko04146	Peroxisome	4/1152	89/7206	0.00120936537767
ko05205	Proteoglycans in cancer	25/1152	271/7206	0.00127558873437
ko00520	Amino sugar and nucleotide sugar metabolism	1/1152	55/7206	0.00132693197139
ko04612	Antigen processing and presentation	3/1152	77/7206	0.00152988129071
ko05110	Vibrio cholerae infection	20/1152	63/7206	0.00157716177729
ko04976	Bile secretion	24/1152	80/7206	0.00175149266774
ko04371	Apelin signaling pathway	44/1152	177/7206	0.00240117152943
ko04630	Jak-STAT signaling pathway	9/1152	132/7206	0.0024861484235
ko04014	Ras signaling pathway	63/1152	279/7206	0.00341115911181
ko04626	Plant-pathogen interaction	8/1152	18/7206	0.00405019079059
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1152	100/7206	0.00538813076007
ko04915	Estrogen signaling pathway	33/1152	131/7206	0.00551821394466
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1152	59/7206	0.0062643022002
ko03022	Basal transcription factors	1/1152	44/7206	0.00674166147929
ko00071	Fatty acid degradation	1/1152	45/7206	0.00680731324449
ko04064	NF-kappa B signaling pathway	6/1152	96/7206	0.00707149233635
ko03420	Nucleotide excision repair	1/1152	46/7206	0.00711233801168
ko04657	IL-17 signaling pathway	5/1152	87/7206	0.00727559014513
ko00280	Valine, leucine and isoleucine degradation	2/1152	54/7206	0.00843232786561
ko05215	Prostate cancer	8/1152	111/7206	0.00860323107963
ko05321	Inflammatory bowel disease (IBD)	2/1152	56/7206	0.00891896737933
ko04217	Necroptosis	16/1152	178/7206	0.00922529295267
ko05131	Shigellosis	5/1152	82/7206	0.00977166099635
ko05140	Leishmaniasis	4/1152	75/7206	0.0101499516005
ko04923	Regulation of lipolysis in adipocytes	21/1152	77/7206	0.011341480423
ko04912	GnRH signaling pathway	30/1152	122/7206	0.0123429577701
ko00590	Arachidonic acid metabolism	2/1152	52/7206	0.0123440107975
ko05222	Small cell lung cancer	6/1152	89/7206	0.0129824524833
ko04930	Type II diabetes mellitus	16/1152	54/7206	0.0134444222119
ko04622	RIG-I-like receptor signaling pathway	3/1152	62/7206	0.0135355821298
ko04214	Apoptosis - fly	4/1152	72/7206	0.0140376310954
ko04270	Vascular smooth muscle contraction	36/1152	154/7206	0.0143543809803
ko04922	Glucagon signaling pathway	31/1152	128/7206	0.0144365149033
ko04916	Melanogenesis	34/1152	142/7206	0.0144692943075
ko04510	Focal adhesion	25/1152	240/7206	0.0153573913497
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1152	14/7206	0.0155666456191
ko04658	Th1 and Th2 cell differentiation	7/1152	96/7206	0.0165833483347
ko05133	Pertussis	6/1152	87/7206	0.0177185090009
ko05166	HTLV-I infection	32/1152	292/7206	0.0177360350632
ko04610	Complement and coagulation cascades	5/1152	79/7206	0.019159640731
ko03410	Base excision repair	1/1152	38/7206	0.0233511763706
ko04210	Apoptosis	18/1152	180/7206	0.023525145448
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1152	182/7206	0.0236514532561
ko00240	Pyrimidine metabolism	9/1152	110/7206	0.0248722252667
ko04115	p53 signaling pathway	5/1152	74/7206	0.0253781952359
ko05145	Toxoplasmosis	11/1152	126/7206	0.026368605215
ko05219	Bladder cancer	2/1152	48/7206	0.0269508834023
ko04620	Toll-like receptor signaling pathway	8/1152	100/7206	0.0271646992092
ko00640	Propanoate metabolism	1/1152	34/7206	0.0334536243071
ko00310	Lysine degradation	5/1152	73/7206	0.0351699058042
ko05200	Pathways in cancer	62/1152	492/7206	0.0352753209783
ko05144	Malaria	2/1152	45/7206	0.0382168602167
ko04964	Proximal tubule bicarbonate reclamation	9/1152	29/7206	0.0385882057218
ko04142	Lysosome	15/1152	151/7206	0.0427032274558
ko04668	TNF signaling pathway	11/1152	120/7206	0.0434507673288
ko04711	Circadian rhythm - fly	5/1152	13/7206	0.0435327755526
ko04114	Oocyte meiosis	31/1152	139/7206	0.046495511499
ko03320	PPAR signaling pathway	5/1152	69/7206	0.0469246740239