ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	197/1177	423/7206	1.36602991486e-51
ko04724	Glutamatergic synapse	90/1177	152/7206	8.3921195028e-34
ko05033	Nicotine addiction	48/1177	56/7206	2.77548410947e-30
ko05032	Morphine addiction	69/1177	110/7206	2.76073834583e-28
ko04713	Circadian entrainment	75/1177	136/7206	1.4707723902e-25
ko04727	GABAergic synapse	65/1177	110/7206	1.38089694037e-24
ko04721	Synaptic vesicle cycle	51/1177	80/7206	1.17743225693e-21
ko04728	Dopaminergic synapse	84/1177	185/7206	4.51481418287e-21
ko04725	Cholinergic synapse	75/1177	160/7206	6.23615641262e-20
ko04024	cAMP signaling pathway	106/1177	279/7206	5.9554950724e-19
ko04020	Calcium signaling pathway	102/1177	265/7206	8.08332094043e-19
ko04723	Retrograde endocannabinoid signaling	77/1177	175/7206	2.10507698502e-18
ko04726	Serotonergic synapse	60/1177	137/7206	1.75596543115e-14
ko04911	Insulin secretion	54/1177	117/7206	2.53260254574e-14
ko04921	Oxytocin signaling pathway	79/1177	209/7206	2.73258600453e-14
ko04742	Taste transduction	36/1177	61/7206	3.91071445076e-14
ko04744	Phototransduction	25/1177	36/7206	1.63195286664e-12
ko05031	Amphetamine addiction	43/1177	91/7206	4.25970721045e-12
ko04720	Long-term potentiation	44/1177	99/7206	3.18849694197e-11
ko04261	Adrenergic signaling in cardiomyocytes	72/1177	205/7206	3.30533088764e-11
ko03040	Spliceosome	1/1177	145/7206	1.95321084154e-10
ko04970	Salivary secretion	41/1177	95/7206	4.5830619541e-10
ko04360	Axon guidance	76/1177	233/7206	6.41411576611e-10
ko05203	Viral carcinogenesis	15/1177	277/7206	2.86988449083e-08
ko04925	Aldosterone synthesis and secretion	39/1177	105/7206	1.82965687075e-07
ko04022	cGMP-PKG signaling pathway	65/1177	216/7206	2.95746513496e-07
ko05030	Cocaine addiction	30/1177	73/7206	3.72200701245e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1177	74/7206	5.29620080331e-07
ko05322	Systemic lupus erythematosus	5/1177	151/7206	5.81162516388e-07
ko05168	Herpes simplex infection	8/1177	182/7206	7.29400706753e-07
ko04060	Cytokine-cytokine receptor interaction	9/1177	191/7206	8.29649690924e-07
ko05164	Influenza A	7/1177	167/7206	1.2983648025e-06
ko03013	RNA transport	7/1177	166/7206	1.90723768401e-06
ko04971	Gastric acid secretion	35/1177	98/7206	2.64462254961e-06
ko04070	Phosphatidylinositol signaling system	38/1177	112/7206	3.89232244212e-06
ko04010	MAPK signaling pathway	84/1177	321/7206	4.35905677919e-06
ko04621	NOD-like receptor signaling pathway	7/1177	157/7206	5.52773233417e-06
ko04740	Olfactory transduction	29/1177	80/7206	1.21140900549e-05
ko04966	Collecting duct acid secretion	14/1177	26/7206	1.23258207164e-05
ko04514	Cell adhesion molecules (CAMs)	41/1177	130/7206	1.87268399946e-05
ko04924	Renin secretion	30/1177	86/7206	2.31358492761e-05
ko04141	Protein processing in endoplasmic reticulum	11/1177	184/7206	2.82116199687e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1177	79/7206	3.79755791403e-05
ko04972	Pancreatic secretion	35/1177	111/7206	7.3009308326e-05
ko04745	Phototransduction - fly	16/1177	38/7206	0.00014274588145
ko04610	Complement and coagulation cascades	2/1177	79/7206	0.000171659902552
ko03008	Ribosome biogenesis in eukaryotes	2/1177	79/7206	0.000171659902552
ko05414	Dilated cardiomyopathy	34/1177	112/7206	0.00023897088685
ko04014	Ras signaling pathway	69/1177	279/7206	0.000254287538103
ko04612	Antigen processing and presentation	2/1177	77/7206	0.000259627726086
ko04120	Ubiquitin mediated proteolysis	8/1177	138/7206	0.000266923247157
ko04730	Long-term depression	26/1177	78/7206	0.000275590374378
ko05169	Epstein-Barr virus infection	16/1177	206/7206	0.000366269962761
ko04110	Cell cycle	9/1177	145/7206	0.000374185838727
ko04540	Gap junction	37/1177	128/7206	0.000384056702412
ko05110	Vibrio cholerae infection	22/1177	63/7206	0.00040996559551
ko04260	Cardiac muscle contraction	30/1177	98/7206	0.000453567495838
ko04072	Phospholipase D signaling pathway	51/1177	197/7206	0.00056190004372
ko04750	Inflammatory mediator regulation of TRP channels	34/1177	122/7206	0.0011665805541
ko04064	NF-kappa B signaling pathway	5/1177	96/7206	0.00128590018695
ko05205	Proteoglycans in cancer	26/1177	271/7206	0.00142497010212
ko05140	Leishmaniasis	3/1177	75/7206	0.00149814989681
ko04976	Bile secretion	24/1177	80/7206	0.00203115364
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1177	59/7206	0.00223620792041
ko05161	Hepatitis B	14/1177	173/7206	0.00234242996201
ko05162	Measles	8/1177	120/7206	0.00253809613747
ko00240	Pyrimidine metabolism	7/1177	110/7206	0.0025771359618
ko04923	Regulation of lipolysis in adipocytes	23/1177	77/7206	0.00278344779473
ko04146	Peroxisome	5/1177	89/7206	0.0035691674094
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1177	14/7206	0.00361649239703
ko04371	Apelin signaling pathway	44/1177	177/7206	0.00369179203805
ko04915	Estrogen signaling pathway	34/1177	131/7206	0.00408644355446
ko03420	Nucleotide excision repair	1/1177	46/7206	0.00441791477948
ko04626	Plant-pathogen interaction	8/1177	18/7206	0.00464536771619
ko04657	IL-17 signaling pathway	5/1177	87/7206	0.00503290087331
ko00562	Inositol phosphate metabolism	25/1177	89/7206	0.0054473158077
ko00480	Glutathione metabolism	2/1177	55/7206	0.0056995074721
ko05321	Inflammatory bowel disease (IBD)	2/1177	56/7206	0.00571529298806
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1177	100/7206	0.00605082405785
ko03022	Basal transcription factors	1/1177	44/7206	0.00668894044395
ko05144	Malaria	1/1177	45/7206	0.0069846573587
ko00071	Fatty acid degradation	1/1177	45/7206	0.0069846573587
ko05145	Toxoplasmosis	10/1177	126/7206	0.00732677142623
ko04622	RIG-I-like receptor signaling pathway	3/1177	62/7206	0.00923454903633
ko05131	Shigellosis	5/1177	82/7206	0.00978146702001
ko00310	Lysine degradation	4/1177	73/7206	0.00985629864885
ko04630	Jak-STAT signaling pathway	11/1177	132/7206	0.0119325471535
ko00590	Arachidonic acid metabolism	2/1177	52/7206	0.0126202596703
ko05133	Pertussis	6/1177	87/7206	0.0128114994415
ko00330	Arginine and proline metabolism	3/1177	61/7206	0.013473283081
ko04930	Type II diabetes mellitus	16/1177	54/7206	0.0145191445536
ko00630	Glyoxylate and dicarboxylate metabolism	1/1177	38/7206	0.0148791725044
ko03410	Base excision repair	1/1177	38/7206	0.0148791725044
ko00290	Valine, leucine and isoleucine biosynthesis	3/1177	4/7206	0.0152670496748
ko03018	RNA degradation	6/1177	84/7206	0.0174592299189
ko04964	Proximal tubule bicarbonate reclamation	10/1177	29/7206	0.0188605537655
ko05215	Prostate cancer	9/1177	111/7206	0.0189020948709
ko04710	Circadian rhythm	13/1177	43/7206	0.0209308946074
ko04217	Necroptosis	18/1177	178/7206	0.0233736819836
ko04115	p53 signaling pathway	5/1177	74/7206	0.0254622053222
ko04640	Hematopoietic cell lineage	4/1177	64/7206	0.0262054642212
ko00280	Valine, leucine and isoleucine degradation	3/1177	54/7206	0.0264623290671
ko05166	HTLV-I infection	34/1177	292/7206	0.0287308080023
ko04916	Melanogenesis	33/1177	142/7206	0.0291211125648
ko04210	Apoptosis	19/1177	180/7206	0.0319536331576
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1177	92/7206	0.0320452617749
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1177	182/7206	0.032265844681
ko00860	Porphyrin and chlorophyll metabolism	1/1177	34/7206	0.0335165723307
ko04912	GnRH signaling pathway	29/1177	122/7206	0.034649599652
ko00500	Starch and sucrose metabolism	1/1177	35/7206	0.0349760506126
ko04214	Apoptosis - fly	5/1177	72/7206	0.035309566439
ko04658	Th1 and Th2 cell differentiation	8/1177	96/7206	0.0358060328565
ko04270	Vascular smooth muscle contraction	35/1177	154/7206	0.0358355241696
ko05418	Fluid shear stress and atherosclerosis	18/1177	173/7206	0.0365857494992
ko04922	Glucagon signaling pathway	30/1177	128/7206	0.0391641705022
ko01524	Platinum drug resistance	6/1177	76/7206	0.0427924944017
ko05340	Primary immunodeficiency	1/1177	30/7206	0.049342851322