ko pathway ratio_in_study ratio_in_pop p_value ko04380 Osteoclast differentiation 28/561 134/7206 1.01873808673e-06 ko04650 Natural killer cell mediated cytotoxicity 22/561 97/7206 3.6021608147e-06 ko04060 Cytokine-cytokine receptor interaction 34/561 191/7206 3.69889007006e-06 ko04070 Phosphatidylinositol signaling system 23/561 112/7206 1.27715849638e-05 ko04710 Circadian rhythm 13/561 43/7206 1.38652385511e-05 ko05340 Primary immunodeficiency 10/561 30/7206 5.42972928901e-05 ko05321 Inflammatory bowel disease (IBD) 14/561 56/7206 6.92286831167e-05 ko04610 Complement and coagulation cascades 17/561 79/7206 9.31278428707e-05 ko05152 Tuberculosis 30/561 187/7206 0.00013336067579 ko04621 NOD-like receptor signaling pathway 26/561 157/7206 0.000210686327609 ko03040 Spliceosome 1/561 145/7206 0.000213080909958 ko05145 Toxoplasmosis 22/561 126/7206 0.000283742458754 ko03013 RNA transport 2/561 166/7206 0.000321426552385 ko04658 Th1 and Th2 cell differentiation 18/561 96/7206 0.000368338420391 ko04137 Mitophagy - animal 16/561 82/7206 0.000485878200015 ko00120 Primary bile acid biosynthesis 7/561 20/7206 0.000527605008074 ko05140 Leishmaniasis 15/561 75/7206 0.000550303994713 ko04659 Th17 cell differentiation 19/561 106/7206 0.000637347781137 ko03010 Ribosome 1/561 129/7206 0.000669219691603 ko04630 Jak-STAT signaling pathway 22/561 132/7206 0.000743460610433 ko04933 AGE-RAGE signaling pathway in diabetic complications 21/561 135/7206 0.00183175957333 ko04020 Calcium signaling pathway 35/561 265/7206 0.00213407330767 ko05167 Kaposi's sarcoma-associated herpesvirus infection 27/561 191/7206 0.00227343348095 ko01040 Biosynthesis of unsaturated fatty acids 7/561 25/7206 0.00232306676402 ko05034 Alcoholism 7/561 238/7206 0.00284089106445 ko05164 Influenza A 24/561 167/7206 0.00306463289286 ko04064 NF-kappa B signaling pathway 16/561 96/7206 0.00318240934039 ko04217 Necroptosis 24/561 178/7206 0.00682438002445 ko04670 Leukocyte transendothelial migration 21/561 151/7206 0.00830979205121 ko04662 B cell receptor signaling pathway 14/561 88/7206 0.00837186811935 ko05162 Measles 18/561 120/7206 0.00858519349371 ko05160 Hepatitis C 21/561 153/7206 0.00910784352885 ko04660 T cell receptor signaling pathway 18/561 124/7206 0.0098486026573 ko04611 Platelet activation 22/561 163/7206 0.0109043329633 ko00350 Tyrosine metabolism 7/561 33/7206 0.011996151188 ko00564 Glycerophospholipid metabolism 15/561 99/7206 0.0121105298549 ko00140 Steroid hormone biosynthesis 8/561 41/7206 0.0123592481882 ko04960 Aldosterone-regulated sodium reabsorption 8/561 41/7206 0.0123592481882 ko04620 Toll-like receptor signaling pathway 15/561 100/7206 0.0127753258946 ko00592 alpha-Linolenic acid metabolism 5/561 19/7206 0.0130512094837 ko05322 Systemic lupus erythematosus 4/561 151/7206 0.013153978221 ko00051 Fructose and mannose metabolism 8/561 42/7206 0.0142590063402 ko04072 Phospholipase D signaling pathway 25/561 197/7206 0.0143821699961 ko04711 Circadian rhythm - fly 4/561 13/7206 0.0147318951731 ko04921 Oxytocin signaling pathway 26/561 209/7206 0.0173300010723 ko04110 Cell cycle 4/561 145/7206 0.0179525658805 ko05150 Staphylococcus aureus infection 7/561 36/7206 0.0191552260723 ko03320 PPAR signaling pathway 11/561 69/7206 0.0203606948822 ko05418 Fluid shear stress and atherosclerosis 22/561 173/7206 0.0205624467336 ko04672 Intestinal immune network for IgA production 7/561 37/7206 0.0220919215793 ko05168 Herpes simplex infection 23/561 182/7206 0.0234959152029 ko00330 Arginine and proline metabolism 10/561 61/7206 0.0253126536282 ko00562 Inositol phosphate metabolism 13/561 89/7206 0.0256454550769 ko04922 Glucagon signaling pathway 17/561 128/7206 0.0285246479949 ko00561 Glycerolipid metabolism 10/561 63/7206 0.0285436047749 ko05224 Breast cancer 6/561 174/7206 0.0303244128038 ko04390 Hippo signaling pathway 7/561 188/7206 0.0370868992307 ko00950 Isoquinoline alkaloid biosynthesis 3/561 10/7206 0.0372543585057 ko00360 Phenylalanine metabolism 4/561 17/7206 0.0382804935261 ko04666 Fc gamma R-mediated phagocytosis 16/561 122/7206 0.0383814574596 ko04066 HIF-1 signaling pathway 16/561 123/7206 0.0395669635355 ko04924 Renin secretion 12/561 86/7206 0.0410250507479 ko04925 Aldosterone synthesis and secretion 14/561 105/7206 0.041791304297 ko03015 mRNA surveillance pathway 2/561 93/7206 0.0476370011956 ko05231 Choline metabolism in cancer 17/561 134/7206 0.0480838444915 ko04664 Fc epsilon RI signaling pathway 11/561 77/7206 0.0493368334458