ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 43/413 191/7206 2.49885392271e-15 ko04512 ECM-receptor interaction 26/413 79/7206 7.44349283573e-14 ko04380 Osteoclast differentiation 30/413 134/7206 5.80788494568e-11 ko04510 Focal adhesion 39/413 240/7206 2.03528462164e-09 ko04933 AGE-RAGE signaling pathway in diabetic complications 27/413 135/7206 7.64011163737e-09 ko05144 Malaria 15/413 45/7206 1.29685724623e-08 ko04668 TNF signaling pathway 24/413 120/7206 5.31486654288e-08 ko04621 NOD-like receptor signaling pathway 28/413 157/7206 5.56471688731e-08 ko04610 Complement and coagulation cascades 18/413 79/7206 3.3093407381e-07 ko04974 Protein digestion and absorption 19/413 96/7206 1.57479133728e-06 ko05323 Rheumatoid arthritis 18/413 89/7206 2.13927314311e-06 ko04064 NF-kappa B signaling pathway 18/413 96/7206 6.64923943756e-06 ko05164 Influenza A 25/413 167/7206 8.13677431988e-06 ko05321 Inflammatory bowel disease (IBD) 13/413 56/7206 1.17306434386e-05 ko04672 Intestinal immune network for IgA production 10/413 37/7206 2.94935046916e-05 ko04630 Jak-STAT signaling pathway 20/413 132/7206 5.51737655097e-05 ko04151 PI3K-Akt signaling pathway 42/413 390/7206 6.81365321519e-05 ko05145 Toxoplasmosis 19/413 126/7206 9.02571907444e-05 ko05146 Amoebiasis 16/413 99/7206 0.000140891649886 ko05162 Measles 18/413 120/7206 0.000147599597016 ko05034 Alcoholism 2/413 238/7206 0.000164653512441 ko04611 Platelet activation 22/413 163/7206 0.000199610870621 ko05167 Kaposi's sarcoma-associated herpesvirus infection 24/413 191/7206 0.000358201485848 ko05161 Hepatitis B 22/413 173/7206 0.000366236952169 ko04657 IL-17 signaling pathway 14/413 87/7206 0.000381618277662 ko04662 B cell receptor signaling pathway 14/413 88/7206 0.000430634767429 ko04620 Toll-like receptor signaling pathway 15/413 100/7206 0.00052013574566 ko04660 T cell receptor signaling pathway 17/413 124/7206 0.000660579027712 ko00643 Styrene degradation 3/413 4/7206 0.000715977676836 ko05150 Staphylococcus aureus infection 8/413 36/7206 0.000794602703833 ko03013 RNA transport 1/413 166/7206 0.00104784371567 ko04658 Th1 and Th2 cell differentiation 14/413 96/7206 0.00105383278517 ko04670 Leukocyte transendothelial migration 19/413 151/7206 0.00107763155351 ko04650 Natural killer cell mediated cytotoxicity 14/413 97/7206 0.00116884061369 ko05160 Hepatitis C 19/413 153/7206 0.00122973802517 ko05133 Pertussis 13/413 87/7206 0.00125398925424 ko04640 Hematopoietic cell lineage 10/413 64/7206 0.0032024825267 ko03040 Spliceosome 1/413 145/7206 0.00326579364809 ko05140 Leishmaniasis 11/413 75/7206 0.00338524306308 ko04723 Retrograde endocannabinoid signaling 2/413 175/7206 0.00436776984109 ko04666 Fc gamma R-mediated phagocytosis 15/413 122/7206 0.00469151828541 ko05200 Pathways in cancer 43/413 492/7206 0.00471234404683 ko04114 Oocyte meiosis 1/413 139/7206 0.0048015852049 ko05168 Herpes simplex infection 20/413 182/7206 0.00512339245678 ko05340 Primary immunodeficiency 6/413 30/7206 0.00626300662467 ko05166 HTLV-I infection 28/413 292/7206 0.00655030406741 ko05418 Fluid shear stress and atherosclerosis 19/413 173/7206 0.00687685770031 ko04270 Vascular smooth muscle contraction 17/413 154/7206 0.0079183162218 ko04623 Cytosolic DNA-sensing pathway 7/413 41/7206 0.00796960909327 ko04659 Th17 cell differentiation 13/413 106/7206 0.00910650347877 ko04728 Dopaminergic synapse 3/413 185/7206 0.00961308754484 ko05016 Huntington's disease 4/413 215/7206 0.0102954608479 ko00190 Oxidative phosphorylation 1/413 127/7206 0.0104261542581 ko05142 Chagas disease (American trypanosomiasis) 15/413 130/7206 0.0111428933002 ko04724 Glutamatergic synapse 2/413 152/7206 0.0123041067851 ko05132 Salmonella infection 12/413 98/7206 0.0128019062014 ko04810 Regulation of actin cytoskeleton 25/413 264/7206 0.0141005018843 ko05410 Hypertrophic cardiomyopathy (HCM) 12/413 100/7206 0.014113184734 ko05205 Proteoglycans in cancer 25/413 271/7206 0.0160889769113 ko05222 Small cell lung cancer 11/413 89/7206 0.0173941932084 ko05219 Bladder cancer 7/413 48/7206 0.0185275223073 ko04514 Cell adhesion molecules (CAMs) 14/413 130/7206 0.0203615341088 ko04622 RIG-I-like receptor signaling pathway 8/413 62/7206 0.0242741674834 ko05131 Shigellosis 10/413 82/7206 0.0258386101189 ko04550 Signaling pathways regulating pluripotency of stem cells 3/413 165/7206 0.0258443939742 ko05212 Pancreatic cancer 10/413 83/7206 0.0268648309521 ko04914 Progesterone-mediated oocyte maturation 1/413 104/7206 0.0307125990124 ko01200 Carbon metabolism 2/413 128/7206 0.0340644887736 ko05012 Parkinson's disease 3/413 155/7206 0.0351211691392 ko05416 Viral myocarditis 7/413 55/7206 0.0363463392563 ko05134 Legionellosis 9/413 74/7206 0.0371396980088 ko00350 Tyrosine metabolism 5/413 33/7206 0.0380349854673 ko05120 Epithelial cell signaling in Helicobacter pylori infection 10/413 92/7206 0.0412487032518 ko04072 Phospholipase D signaling pathway 18/413 197/7206 0.0430138078353 ko04260 Cardiac muscle contraction 1/413 98/7206 0.0447635876256