ko pathway ratio_in_study ratio_in_pop p_value ko04380 Osteoclast differentiation 29/359 134/7206 9.58576401951e-12 ko04060 Cytokine-cytokine receptor interaction 27/359 191/7206 7.29001961153e-07 ko05164 Influenza A 24/359 167/7206 2.27714862442e-06 ko05140 Leishmaniasis 15/359 75/7206 3.18839153792e-06 ko04621 NOD-like receptor signaling pathway 22/359 157/7206 9.20585146989e-06 ko05161 Hepatitis B 23/359 173/7206 1.39830563844e-05 ko04668 TNF signaling pathway 18/359 120/7206 2.37582357977e-05 ko05162 Measles 18/359 120/7206 2.37582357977e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 24/359 191/7206 2.37825796863e-05 ko00120 Primary bile acid biosynthesis 7/359 20/7206 3.16938080797e-05 ko04933 AGE-RAGE signaling pathway in diabetic complications 19/359 135/7206 3.54307159719e-05 ko04710 Circadian rhythm 10/359 43/7206 3.64152659887e-05 ko05160 Hepatitis C 20/359 153/7206 6.51476397366e-05 ko04064 NF-kappa B signaling pathway 15/359 96/7206 7.02521645e-05 ko04662 B cell receptor signaling pathway 14/359 88/7206 0.000100005433452 ko04620 Toll-like receptor signaling pathway 15/359 100/7206 0.000113419721808 ko04610 Complement and coagulation cascades 13/359 79/7206 0.000124012158931 ko04659 Th17 cell differentiation 15/359 106/7206 0.000220995840832 ko04658 Th1 and Th2 cell differentiation 14/359 96/7206 0.000258922507255 ko04650 Natural killer cell mediated cytotoxicity 14/359 97/7206 0.000289202222169 ko04666 Fc gamma R-mediated phagocytosis 16/359 122/7206 0.000335639363041 ko04660 T cell receptor signaling pathway 16/359 124/7206 0.000404465443287 ko05145 Toxoplasmosis 16/359 126/7206 0.000485116007116 ko05168 Herpes simplex infection 20/359 182/7206 0.000769078583047 ko04630 Jak-STAT signaling pathway 16/359 132/7206 0.000814985791533 ko05152 Tuberculosis 20/359 187/7206 0.00103236629426 ko04611 Platelet activation 18/359 163/7206 0.00141080648817 ko05321 Inflammatory bowel disease (IBD) 9/359 56/7206 0.0016189032123 ko04068 FoxO signaling pathway 18/359 167/7206 0.00175210586505 ko04137 Mitophagy - animal 11/359 82/7206 0.00233390768688 ko04711 Circadian rhythm - fly 4/359 13/7206 0.00302539008193 ko05132 Salmonella infection 12/359 98/7206 0.00328072454993 ko04622 RIG-I-like receptor signaling pathway 9/359 62/7206 0.00333362811217 ko05215 Prostate cancer 13/359 111/7206 0.00334364056266 ko05166 HTLV-I infection 26/359 292/7206 0.00356657546687 ko00140 Steroid hormone biosynthesis 7/359 41/7206 0.00372217741205 ko04623 Cytosolic DNA-sensing pathway 7/359 41/7206 0.00372217741205 ko05133 Pertussis 11/359 87/7206 0.00373920221288 ko04931 Insulin resistance 15/359 137/7206 0.0041018721432 ko04217 Necroptosis 18/359 178/7206 0.00425322271375 ko00051 Fructose and mannose metabolism 7/359 42/7206 0.00428001274115 ko04930 Type II diabetes mellitus 8/359 54/7206 0.00488866819856 ko05142 Chagas disease (American trypanosomiasis) 14/359 130/7206 0.0063310141593 ko05144 Malaria 7/359 45/7206 0.00633558195897 ko05231 Choline metabolism in cancer 14/359 134/7206 0.007665584347 ko04672 Intestinal immune network for IgA production 6/359 37/7206 0.00918729433174 ko04066 HIF-1 signaling pathway 13/359 123/7206 0.00976003890513 ko03040 Spliceosome 1/359 145/7206 0.010470067284 ko04657 IL-17 signaling pathway 10/359 87/7206 0.0108574220522 ko04922 Glucagon signaling pathway 13/359 128/7206 0.0123917312152 ko05323 Rheumatoid arthritis 10/359 89/7206 0.0126445996168 ko04210 Apoptosis 17/359 180/7206 0.0132771932385 ko04664 Fc epsilon RI signaling pathway 9/359 77/7206 0.0138040829848 ko05034 Alcoholism 4/359 238/7206 0.0141565980907 ko05340 Primary immunodeficiency 5/359 30/7206 0.0151969434235 ko04022 cGMP-PKG signaling pathway 19/359 216/7206 0.0157132997968 ko05146 Amoebiasis 11/359 99/7206 0.0160306643155 ko03013 RNA transport 2/359 166/7206 0.0175914276947 ko05230 Central carbon metabolism in cancer 9/359 81/7206 0.0187784714736 ko05418 Fluid shear stress and atherosclerosis 16/359 173/7206 0.019092002674 ko00190 Oxidative phosphorylation 1/359 127/7206 0.0215056714163 ko04670 Leukocyte transendothelial migration 14/359 151/7206 0.0217515561783 ko00350 Tyrosine metabolism 5/359 33/7206 0.0224178419851 ko04070 Phosphatidylinositol signaling system 11/359 112/7206 0.0264119090334 ko04072 Phospholipase D signaling pathway 17/359 197/7206 0.0284685256033 ko04062 Chemokine signaling pathway 17/359 201/7206 0.0307064329473 ko05150 Staphylococcus aureus infection 5/359 36/7206 0.0315578619776 ko04917 Prolactin signaling pathway 9/359 87/7206 0.0399175410461 ko04725 Cholinergic synapse 14/359 160/7206 0.0399691117066 ko05031 Amphetamine addiction 9/359 91/7206 0.0459661363906