ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 121/735 423/7206 3.08959612754e-28 ko04724 Glutamatergic synapse 65/735 152/7206 4.10460873134e-26 ko05033 Nicotine addiction 37/735 56/7206 5.80289261609e-24 ko04713 Circadian entrainment 55/735 136/7206 7.85429216369e-21 ko05032 Morphine addiction 48/735 110/7206 5.52267688184e-20 ko04728 Dopaminergic synapse 64/735 185/7206 8.16196216161e-20 ko04727 GABAergic synapse 47/735 110/7206 3.94346510142e-19 ko04723 Retrograde endocannabinoid signaling 58/735 175/7206 4.77221922279e-17 ko04725 Cholinergic synapse 55/735 160/7206 5.04339604571e-17 ko04721 Synaptic vesicle cycle 37/735 80/7206 1.07258149985e-16 ko04911 Insulin secretion 43/735 117/7206 9.58532269239e-15 ko04024 cAMP signaling pathway 72/735 279/7206 2.43534631276e-14 ko04726 Serotonergic synapse 44/735 137/7206 1.14871445447e-12 ko04020 Calcium signaling pathway 66/735 265/7206 2.12262960647e-12 ko04720 Long-term potentiation 35/735 99/7206 1.13844469569e-11 ko04921 Oxytocin signaling pathway 55/735 209/7206 1.45356754716e-11 ko05031 Amphetamine addiction 32/735 91/7206 1.03748724086e-10 ko04744 Phototransduction 19/735 36/7206 1.87447149975e-10 ko04261 Adrenergic signaling in cardiomyocytes 49/735 205/7206 6.94220086532e-09 ko04925 Aldosterone synthesis and secretion 30/735 105/7206 9.65333862065e-08 ko05030 Cocaine addiction 24/735 73/7206 1.02238884696e-07 ko04970 Salivary secretion 28/735 95/7206 1.25568845443e-07 ko04742 Taste transduction 21/735 61/7206 2.66719092229e-07 ko04971 Gastric acid secretion 26/735 98/7206 3.24282811846e-06 ko04972 Pancreatic secretion 28/735 111/7206 4.02071428686e-06 ko04070 Phosphatidylinositol signaling system 28/735 112/7206 4.85281070987e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 21/735 74/7206 9.15980332538e-06 ko04745 Phototransduction - fly 14/735 38/7206 1.09091548525e-05 ko04010 MAPK signaling pathway 58/735 321/7206 1.12544973824e-05 ko04730 Long-term depression 21/735 78/7206 2.22780750441e-05 ko05322 Systemic lupus erythematosus 2/735 151/7206 2.86506968181e-05 ko03040 Spliceosome 2/735 145/7206 3.99909389618e-05 ko04740 Olfactory transduction 20/735 80/7206 0.000108871961655 ko04966 Collecting duct acid secretion 10/735 26/7206 0.000132966648132 ko04022 cGMP-PKG signaling pathway 40/735 216/7206 0.000145798653667 ko05164 Influenza A 4/735 167/7206 0.000146694290062 ko04750 Inflammatory mediator regulation of TRP channels 26/735 122/7206 0.000220408735208 ko04540 Gap junction 27/735 128/7206 0.000290285573535 ko04060 Cytokine-cytokine receptor interaction 6/735 191/7206 0.000371234017746 ko04964 Proximal tubule bicarbonate reclamation 10/735 29/7206 0.000377452649543 ko05162 Measles 2/735 120/7206 0.000389340131315 ko05110 Vibrio cholerae infection 16/735 63/7206 0.000430763874037 ko04072 Phospholipase D signaling pathway 36/735 197/7206 0.000459583066545 ko04120 Ubiquitin mediated proteolysis 3/735 138/7206 0.000516213215827 ko04514 Cell adhesion molecules (CAMs) 26/735 130/7206 0.000647809511456 ko03013 RNA transport 5/735 166/7206 0.000663044551403 ko05168 Herpes simplex infection 6/735 182/7206 0.000709632391501 ko04924 Renin secretion 19/735 86/7206 0.000952987606186 ko04260 Cardiac muscle contraction 21/735 98/7206 0.00102298542631 ko05203 Viral carcinogenesis 13/735 277/7206 0.0011057243072 ko04626 Plant-pathogen interaction 7/735 18/7206 0.00129601285655 ko04510 Focal adhesion 11/735 240/7206 0.00220073869549 ko04630 Jak-STAT signaling pathway 4/735 132/7206 0.00329398942402 ko04612 Antigen processing and presentation 1/735 77/7206 0.00397419176734 ko04621 NOD-like receptor signaling pathway 6/735 157/7206 0.00475792728899 ko04141 Protein processing in endoplasmic reticulum 8/735 184/7206 0.00613907264576 ko05169 Epstein-Barr virus infection 10/735 206/7206 0.00704081900646 ko04961 Endocrine and other factor-regulated calcium reabsorption 13/735 59/7206 0.00728034852899 ko04915 Estrogen signaling pathway 23/735 131/7206 0.00825096163062 ko04114 Oocyte meiosis 24/735 139/7206 0.00996513600016 ko04110 Cell cycle 6/735 145/7206 0.0118722839935 ko05034 Alcoholism 36/735 238/7206 0.0159338888789 ko04064 NF-kappa B signaling pathway 3/735 96/7206 0.0164329124384 ko04371 Apelin signaling pathway 28/735 177/7206 0.0165318951999 ko05166 HTLV-I infection 18/735 292/7206 0.0176158306047 ko05010 Alzheimer's disease 31/735 202/7206 0.0181247097309 ko00680 Methane metabolism 8/735 34/7206 0.0185592826821 ko04360 Axon guidance 35/735 233/7206 0.020083490205 ko04930 Type II diabetes mellitus 11/735 54/7206 0.0214876803092 ko03008 Ribosome biogenesis in eukaryotes 2/735 79/7206 0.0224519371858 ko05161 Hepatitis B 9/735 173/7206 0.0294784052497 ko05205 Proteoglycans in cancer 17/735 271/7206 0.0309679849721 ko04918 Thyroid hormone synthesis 15/735 86/7206 0.0315330343336 ko05140 Leishmaniasis 2/735 75/7206 0.0318801923411 ko04960 Aldosterone-regulated sodium reabsorption 9/735 41/7206 0.0320636481862 ko05222 Small cell lung cancer 3/735 89/7206 0.0322827116024 ko04711 Circadian rhythm - fly 4/735 13/7206 0.0362771879212 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 14/735 79/7206 0.0372572074098 ko04810 Regulation of actin cytoskeleton 17/735 264/7206 0.038087457326 ko00480 Glutathione metabolism 1/735 55/7206 0.0403340771197 ko04014 Ras signaling pathway 39/735 279/7206 0.0427777872933 ko03320 PPAR signaling pathway 2/735 69/7206 0.0435527934088 ko05200 Pathways in cancer 37/735 492/7206 0.0444449843588 ko00604 Glycosphingolipid biosynthesis - ganglio series 4/735 14/7206 0.046807109261 ko00562 Inositol phosphate metabolism 15/735 89/7206 0.0498867443151