ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 136/907 423/7206 8.39661503249e-28 ko04724 Glutamatergic synapse 71/907 152/7206 1.28084679042e-25 ko04721 Synaptic vesicle cycle 48/907 80/7206 8.21395616527e-24 ko05033 Nicotine addiction 38/907 56/7206 6.94591666435e-22 ko04728 Dopaminergic synapse 67/907 185/7206 5.87254893008e-17 ko05032 Morphine addiction 47/907 110/7206 1.96606879057e-15 ko04713 Circadian entrainment 53/907 136/7206 3.41096734403e-15 ko04727 GABAergic synapse 46/907 110/7206 1.05459871266e-14 ko04725 Cholinergic synapse 54/907 160/7206 1.87569409406e-12 ko04723 Retrograde endocannabinoid signaling 57/907 175/7206 2.39943524661e-12 ko04911 Insulin secretion 39/907 117/7206 3.58007621684e-09 ko04024 cAMP signaling pathway 70/907 279/7206 5.77036081819e-09 ko04726 Serotonergic synapse 42/907 137/7206 2.32915330792e-08 ko05031 Amphetamine addiction 31/907 91/7206 8.28196709741e-08 ko03040 Spliceosome 1/907 145/7206 9.15109411542e-08 ko04742 Taste transduction 24/907 61/7206 1.09998864076e-07 ko04360 Axon guidance 58/907 233/7206 1.76334977281e-07 ko05030 Cocaine addiction 25/907 73/7206 1.3286572873e-06 ko04060 Cytokine-cytokine receptor interaction 5/907 191/7206 1.33207283703e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 25/907 74/7206 1.77095704751e-06 ko04744 Phototransduction 16/907 36/7206 2.1811728683e-06 ko04261 Adrenergic signaling in cardiomyocytes 50/907 205/7206 2.82229588381e-06 ko04966 Collecting duct acid secretion 13/907 26/7206 3.92034132006e-06 ko05168 Herpes simplex infection 5/907 182/7206 4.03041519361e-06 ko05164 Influenza A 4/907 167/7206 4.59764485505e-06 ko04720 Long-term potentiation 29/907 99/7206 8.5994294713e-06 ko04514 Cell adhesion molecules (CAMs) 35/907 130/7206 1.116010742e-05 ko05203 Viral carcinogenesis 13/907 277/7206 1.1240648878e-05 ko03013 RNA transport 5/907 166/7206 2.48855553699e-05 ko04921 Oxytocin signaling pathway 48/907 209/7206 2.77765134694e-05 ko04970 Salivary secretion 27/907 95/7206 2.93399601195e-05 ko00604 Glycosphingolipid biosynthesis - ganglio series 8/907 14/7206 9.11305435619e-05 ko04740 Olfactory transduction 23/907 80/7206 0.000105645317549 ko04120 Ubiquitin mediated proteolysis 4/907 138/7206 0.00012811256027 ko05162 Measles 3/907 120/7206 0.00014368898744 ko04621 NOD-like receptor signaling pathway 6/907 157/7206 0.000226774739258 ko04010 MAPK signaling pathway 63/907 321/7206 0.000270398935154 ko05322 Systemic lupus erythematosus 6/907 151/7206 0.000444711205172 ko03008 Ribosome biogenesis in eukaryotes 1/907 79/7206 0.000487951151677 ko04260 Cardiac muscle contraction 25/907 98/7206 0.000545736417211 ko04540 Gap junction 30/907 128/7206 0.000632200606185 ko04141 Protein processing in endoplasmic reticulum 9/907 184/7206 0.000649956335311 ko04730 Long-term depression 21/907 78/7206 0.000787688776308 ko04020 Calcium signaling pathway 52/907 265/7206 0.000891093442824 ko04214 Apoptosis - fly 1/907 72/7206 0.00108247039163 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 20/907 79/7206 0.00173855611138 ko05169 Epstein-Barr virus infection 12/907 206/7206 0.00185254550702 ko04961 Endocrine and other factor-regulated calcium reabsorption 16/907 59/7206 0.0023162628711 ko04924 Renin secretion 21/907 86/7206 0.00262771675501 ko04064 NF-kappa B signaling pathway 3/907 96/7206 0.0027400222904 ko04022 cGMP-PKG signaling pathway 42/907 216/7206 0.00338309046121 ko05205 Proteoglycans in cancer 19/907 271/7206 0.00364071914361 ko04640 Hematopoietic cell lineage 1/907 64/7206 0.00365139040339 ko05140 Leishmaniasis 2/907 75/7206 0.0046548831986 ko00330 Arginine and proline metabolism 1/907 61/7206 0.00545641220877 ko04146 Peroxisome 3/907 89/7206 0.00548731435806 ko05110 Vibrio cholerae infection 16/907 63/7206 0.00609439350776 ko04925 Aldosterone synthesis and secretion 23/907 105/7206 0.00694862106996 ko05321 Inflammatory bowel disease (IBD) 1/907 56/7206 0.0078107143701 ko00280 Valine, leucine and isoleucine degradation 1/907 54/7206 0.0117445059858 ko04014 Ras signaling pathway 49/907 279/7206 0.0129051174787 ko04972 Pancreatic secretion 23/907 111/7206 0.0136120981835 ko04612 Antigen processing and presentation 3/907 77/7206 0.0151205299444 ko04145 Phagosome 31/907 162/7206 0.0159289863795 ko04110 Cell cycle 9/907 145/7206 0.0159375318602 ko04915 Estrogen signaling pathway 26/907 131/7206 0.0161261710568 ko00240 Pyrimidine metabolism 6/907 110/7206 0.0198080660333 ko00561 Glycerolipid metabolism 2/907 63/7206 0.0202676359026 ko04371 Apelin signaling pathway 33/907 177/7206 0.0209247378931 ko05146 Amoebiasis 5/907 99/7206 0.0209483502532 ko05034 Alcoholism 42/907 238/7206 0.0217892685636 ko04745 Phototransduction - fly 10/907 38/7206 0.0223839075803 ko04611 Platelet activation 11/907 163/7206 0.0224964337862 ko04140 Autophagy - animal 11/907 164/7206 0.0227539650244 ko04950 Maturity onset diabetes of the young 8/907 29/7206 0.0232179284486 ko04964 Proximal tubule bicarbonate reclamation 8/907 29/7206 0.0232179284486 ko04391 Hippo signaling pathway - fly 19/907 90/7206 0.0233821622639 ko00620 Pyruvate metabolism 1/907 46/7206 0.0251000019441 ko03420 Nucleotide excision repair 1/907 46/7206 0.0251000019441 ko05120 Epithelial cell signaling in Helicobacter pylori infection 19/907 92/7206 0.0257518182514 ko05204 Chemical carcinogenesis 1/907 48/7206 0.0258920506525 ko04976 Bile secretion 17/907 80/7206 0.0262666561922 ko03018 RNA degradation 4/907 84/7206 0.029751430206 ko04971 Gastric acid secretion 20/907 98/7206 0.0299727522725 ko01200 Carbon metabolism 8/907 128/7206 0.0302849696344 ko00310 Lysine degradation 3/907 73/7206 0.0308609460498 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate 5/907 15/7206 0.0317643680971 ko03022 Basal transcription factors 1/907 44/7206 0.0373220576684 ko05166 HTLV-I infection 25/907 292/7206 0.0377227243442 ko05144 Malaria 1/907 45/7206 0.0383703406269 ko00071 Fatty acid degradation 1/907 45/7206 0.0383703406269 ko04930 Type II diabetes mellitus 12/907 54/7206 0.0393311743282 ko00480 Glutathione metabolism 2/907 55/7206 0.0407315621517 ko04138 Autophagy - yeast 4/907 81/7206 0.0409963711658 ko03320 PPAR signaling pathway 3/907 69/7206 0.0422517449577 ko04962 Vasopressin-regulated water reabsorption 13/907 58/7206 0.0431669407523 ko05418 Fluid shear stress and atherosclerosis 13/907 173/7206 0.0474751580796 ko05161 Hepatitis B 13/907 173/7206 0.0474751580796