ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	103/672	423/7206	3.14210981247e-21
ko05033	Nicotine addiction	32/672	56/7206	2.68698723505e-19
ko04724	Glutamatergic synapse	52/672	152/7206	9.66661431339e-18
ko04728	Dopaminergic synapse	54/672	185/7206	5.54295384046e-15
ko04721	Synaptic vesicle cycle	29/672	80/7206	3.8826849816e-11
ko05030	Cocaine addiction	26/672	73/7206	6.32598401508e-10
ko04713	Circadian entrainment	37/672	136/7206	1.10937808519e-09
ko04727	GABAergic synapse	32/672	110/7206	2.46310130493e-09
ko04514	Cell adhesion molecules (CAMs)	35/672	130/7206	4.26896104007e-09
ko04360	Axon guidance	51/672	233/7206	5.84168285962e-09
ko05032	Morphine addiction	31/672	110/7206	1.01874839222e-08
ko04723	Retrograde endocannabinoid signaling	40/672	175/7206	8.28109566227e-08
ko04911	Insulin secretion	30/672	117/7206	1.81335703698e-07
ko05031	Amphetamine addiction	25/672	91/7206	4.71559453356e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	22/672	74/7206	5.22097821735e-07
ko04024	cAMP signaling pathway	52/672	279/7206	8.50989375024e-07
ko04725	Cholinergic synapse	35/672	160/7206	1.25580754848e-06
ko04010	MAPK signaling pathway	57/672	321/7206	1.63803459855e-06
ko03040	Spliceosome	1/672	145/7206	1.71831894138e-05
ko05164	Influenza A	2/672	167/7206	1.98511781094e-05
ko04950	Maturity onset diabetes of the young	11/672	29/7206	3.08160069734e-05
ko04120	Ubiquitin mediated proteolysis	1/672	138/7206	3.94854637336e-05
ko04261	Adrenergic signaling in cardiomyocytes	38/672	205/7206	4.06736042238e-05
ko04060	Cytokine-cytokine receptor interaction	4/672	191/7206	0.000115151431464
ko05203	Viral carcinogenesis	9/672	277/7206	0.000123027730182
ko03013	RNA transport	3/672	166/7206	0.000124800484086
ko04621	NOD-like receptor signaling pathway	3/672	157/7206	0.000258026039958
ko01200	Carbon metabolism	2/672	128/7206	0.000596816352078
ko04730	Long-term depression	17/672	78/7206	0.000683421390887
ko05168	Herpes simplex infection	5/672	182/7206	0.00069392120993
ko04726	Serotonergic synapse	25/672	137/7206	0.000920452535867
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/672	14/7206	0.00100369788067
ko00230	Purine metabolism	6/672	194/7206	0.00102105162616
ko04742	Taste transduction	14/672	61/7206	0.00117023113499
ko04512	ECM-receptor interaction	17/672	79/7206	0.00121595509293
ko05162	Measles	2/672	120/7206	0.00126145918796
ko04974	Protein digestion and absorption	19/672	96/7206	0.00126255726631
ko05169	Epstein-Barr virus infection	7/672	206/7206	0.00142979188309
ko04260	Cardiac muscle contraction	19/672	98/7206	0.00224561200737
ko04720	Long-term potentiation	19/672	99/7206	0.00238699711621
ko05322	Systemic lupus erythematosus	4/672	151/7206	0.00254982809234
ko04140	Autophagy - animal	5/672	164/7206	0.00257824744558
ko04611	Platelet activation	5/672	163/7206	0.00257979084359
ko00240	Pyrimidine metabolism	2/672	110/7206	0.00259475632348
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	16/672	79/7206	0.00262236532793
ko03018	RNA degradation	1/672	84/7206	0.00412702692216
ko04151	PI3K-Akt signaling pathway	53/672	390/7206	0.00527419309644
ko04914	Progesterone-mediated oocyte maturation	2/672	104/7206	0.00558535278668
ko03008	Ribosome biogenesis in eukaryotes	1/672	79/7206	0.00606660504928
ko04932	Non-alcoholic fatty liver disease (NAFLD)	7/672	182/7206	0.00647334152157
ko00430	Taurine and hypotaurine metabolism	5/672	14/7206	0.0068089331309
ko04064	NF-kappa B signaling pathway	2/672	96/7206	0.00766734206794
ko05224	Breast cancer	27/672	174/7206	0.0077470934091
ko04217	Necroptosis	7/672	178/7206	0.00867946005287
ko01524	Platinum drug resistance	1/672	76/7206	0.00890012120992
ko04978	Mineral absorption	9/672	40/7206	0.00987188984845
ko04214	Apoptosis - fly	1/672	72/7206	0.0130621962383
ko00010	Glycolysis / Gluconeogenesis	1/672	74/7206	0.0136155388982
ko04150	mTOR signaling pathway	8/672	184/7206	0.0144407185468
ko04141	Protein processing in endoplasmic reticulum	8/672	184/7206	0.0144407185468
ko04014	Ras signaling pathway	38/672	279/7206	0.0154548725865
ko04146	Peroxisome	2/672	89/7206	0.0157126530089
ko04970	Salivary secretion	16/672	95/7206	0.0190091710992
ko04540	Gap junction	20/672	128/7206	0.0201802026805
ko04142	Lysosome	6/672	151/7206	0.022292293956
ko00564	Glycerophospholipid metabolism	3/672	99/7206	0.0234064174902
ko04391	Hippo signaling pathway - fly	15/672	90/7206	0.0260940585116
ko04913	Ovarian steroidogenesis	1/672	63/7206	0.0277266372975
ko04110	Cell cycle	6/672	145/7206	0.0292139263296
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	6/672	26/7206	0.0293158593342
ko00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/672	8/7206	0.031643056051
ko04138	Autophagy - yeast	2/672	81/7206	0.031967423687
ko05410	Hypertrophic cardiomyopathy (HCM)	16/672	100/7206	0.034944819776
ko05218	Melanoma	14/672	85/7206	0.0358510296455
ko05166	HTLV-I infection	17/672	292/7206	0.0390723105496
ko04211	Longevity regulating pathway	5/672	123/7206	0.041200497053
ko05140	Leishmaniasis	2/672	75/7206	0.0443182501177
ko02024	Quorum sensing	4/672	15/7206	0.0445140492349
ko04015	Rap1 signaling pathway	36/672	278/7206	0.0446898107978
ko04964	Proximal tubule bicarbonate reclamation	6/672	29/7206	0.0477220940108
ko04976	Bile secretion	13/672	80/7206	0.0492780668458