ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	214/1365	423/7206	3.21049596622e-52
ko04724	Glutamatergic synapse	93/1365	152/7206	3.74252053508e-31
ko05033	Nicotine addiction	47/1365	56/7206	7.23329746206e-26
ko04727	GABAergic synapse	70/1365	110/7206	3.66913561804e-25
ko05032	Morphine addiction	70/1365	110/7206	3.66913561804e-25
ko04713	Circadian entrainment	77/1365	136/7206	6.32172902275e-23
ko04721	Synaptic vesicle cycle	52/1365	80/7206	1.34090423313e-19
ko04728	Dopaminergic synapse	88/1365	185/7206	3.10765196467e-19
ko04725	Cholinergic synapse	79/1365	160/7206	1.34746725332e-18
ko04020	Calcium signaling pathway	110/1365	265/7206	6.25331522991e-18
ko04024	cAMP signaling pathway	113/1365	279/7206	1.46269424923e-17
ko04726	Serotonergic synapse	67/1365	137/7206	1.11283002441e-15
ko04742	Taste transduction	40/1365	61/7206	1.46348266504e-15
ko04723	Retrograde endocannabinoid signaling	78/1365	175/7206	3.5986572976e-15
ko04744	Phototransduction	28/1365	36/7206	2.90016742332e-14
ko04911	Insulin secretion	58/1365	117/7206	4.52821822116e-14
ko04921	Oxytocin signaling pathway	85/1365	209/7206	1.39860617939e-13
ko04740	Olfactory transduction	43/1365	80/7206	2.70641058442e-12
ko04970	Salivary secretion	46/1365	95/7206	5.59807672955e-11
ko03010	Ribosome	1/1365	129/7206	7.21841640589e-11
ko03040	Spliceosome	3/1365	145/7206	5.58894606385e-10
ko04022	cGMP-PKG signaling pathway	79/1365	216/7206	5.71463842543e-10
ko04261	Adrenergic signaling in cardiomyocytes	76/1365	205/7206	6.11575211201e-10
ko05031	Amphetamine addiction	43/1365	91/7206	6.36181519896e-10
ko04720	Long-term potentiation	45/1365	99/7206	2.02742314127e-09
ko05168	Herpes simplex infection	8/1365	182/7206	8.05959187169e-09
ko05203	Viral carcinogenesis	19/1365	277/7206	1.11697425792e-08
ko05322	Systemic lupus erythematosus	6/1365	151/7206	7.65096053814e-08
ko03013	RNA transport	8/1365	166/7206	1.15945839958e-07
ko04925	Aldosterone synthesis and secretion	43/1365	105/7206	1.98517508385e-07
ko04060	Cytokine-cytokine receptor interaction	12/1365	191/7206	7.64519872742e-07
ko04971	Gastric acid secretion	39/1365	98/7206	1.4331264091e-06
ko05164	Influenza A	10/1365	167/7206	1.88436286451e-06
ko04966	Collecting duct acid secretion	16/1365	26/7206	1.95936606701e-06
ko04964	Proximal tubule bicarbonate reclamation	17/1365	29/7206	2.42197126131e-06
ko04621	NOD-like receptor signaling pathway	9/1365	157/7206	2.48527608563e-06
ko05030	Cocaine addiction	31/1365	73/7206	3.05415943529e-06
ko04110	Cell cycle	8/1365	145/7206	4.70278010728e-06
ko04924	Renin secretion	34/1365	86/7206	9.43476808649e-06
ko04540	Gap junction	45/1365	128/7206	1.13820784436e-05
ko04730	Long-term depression	31/1365	78/7206	1.60151111801e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1365	79/7206	1.75165758399e-05
ko04972	Pancreatic secretion	40/1365	111/7206	2.23056148589e-05
ko04976	Bile secretion	31/1365	80/7206	3.55512287597e-05
ko04120	Ubiquitin mediated proteolysis	9/1365	138/7206	4.08195002451e-05
ko04141	Protein processing in endoplasmic reticulum	15/1365	184/7206	5.32873206385e-05
ko04360	Axon guidance	69/1365	233/7206	5.86318841898e-05
ko04514	Cell adhesion molecules (CAMs)	44/1365	130/7206	5.86725495418e-05
ko05169	Epstein-Barr virus infection	18/1365	206/7206	6.16796188454e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1365	74/7206	6.51888720207e-05
ko04371	Apelin signaling pathway	54/1365	177/7206	0.000193819816738
ko04745	Phototransduction - fly	17/1365	38/7206	0.000237223700463
ko04270	Vascular smooth muscle contraction	48/1365	154/7206	0.00023745440863
ko04750	Inflammatory mediator regulation of TRP channels	40/1365	122/7206	0.000250295204668
ko04010	MAPK signaling pathway	87/1365	321/7206	0.000253461195732
ko05140	Leishmaniasis	3/1365	75/7206	0.000279176414106
ko04923	Regulation of lipolysis in adipocytes	28/1365	77/7206	0.000332236338128
ko04070	Phosphatidylinositol signaling system	37/1365	112/7206	0.000353001333331
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1365	79/7206	0.000450691010188
ko04330	Notch signaling pathway	2/1365	62/7206	0.000467441403886
ko05161	Hepatitis B	16/1365	173/7206	0.000539246703046
ko04064	NF-kappa B signaling pathway	6/1365	96/7206	0.000567655542342
ko05162	Measles	9/1365	120/7206	0.000586031835806
ko04260	Cardiac muscle contraction	33/1365	98/7206	0.00060457219557
ko05166	HTLV-I infection	34/1365	292/7206	0.00076601245239
ko05414	Dilated cardiomyopathy	36/1365	112/7206	0.000885022127876
ko03420	Nucleotide excision repair	1/1365	46/7206	0.0010967134457
ko04922	Glucagon signaling pathway	39/1365	128/7206	0.00137240283284
ko00520	Amino sugar and nucleotide sugar metabolism	2/1365	55/7206	0.00153853049505
ko03022	Basal transcription factors	1/1365	44/7206	0.00166793562586
ko04014	Ras signaling pathway	74/1365	279/7206	0.00174365367833
ko04610	Complement and coagulation cascades	5/1365	79/7206	0.00219234304963
ko04657	IL-17 signaling pathway	6/1365	87/7206	0.00223735906137
ko05133	Pertussis	6/1365	87/7206	0.00223735906137
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1365	59/7206	0.00229505469935
ko04622	RIG-I-like receptor signaling pathway	3/1365	62/7206	0.00281983749497
ko05110	Vibrio cholerae infection	22/1365	63/7206	0.00303228002661
ko04072	Phospholipase D signaling pathway	54/1365	197/7206	0.00308187052453
ko04612	Antigen processing and presentation	5/1365	77/7206	0.00310823119006
ko05205	Proteoglycans in cancer	33/1365	271/7206	0.00333596455817
ko05131	Shigellosis	6/1365	82/7206	0.00435878638504
ko04930	Type II diabetes mellitus	19/1365	54/7206	0.00455605566178
ko04915	Estrogen signaling pathway	38/1365	131/7206	0.00467471683372
ko04710	Circadian rhythm	16/1365	43/7206	0.00508115609894
ko05145	Toxoplasmosis	12/1365	126/7206	0.00554586706116
ko04658	Th1 and Th2 cell differentiation	8/1365	96/7206	0.00555803614181
ko05321	Inflammatory bowel disease (IBD)	3/1365	56/7206	0.00569624504529
ko04146	Peroxisome	7/1365	89/7206	0.0059379336652
ko04214	Apoptosis - fly	5/1365	72/7206	0.00613680260112
ko04217	Necroptosis	20/1365	178/7206	0.00651571342608
ko00240	Pyrimidine metabolism	10/1365	110/7206	0.00656189725044
ko05410	Hypertrophic cardiomyopathy (HCM)	30/1365	100/7206	0.0066882392429
ko00562	Inositol phosphate metabolism	27/1365	89/7206	0.0091169614129
ko04626	Plant-pathogen interaction	8/1365	18/7206	0.0116696358333
ko00590	Arachidonic acid metabolism	3/1365	52/7206	0.0118922022709
ko04630	Jak-STAT signaling pathway	14/1365	132/7206	0.013137174645
ko04350	TGF-beta signaling pathway	10/1365	103/7206	0.0154177214821
ko04620	Toll-like receptor signaling pathway	10/1365	100/7206	0.0201755387261
ko04210	Apoptosis	22/1365	180/7206	0.0203376863125
ko00480	Glutathione metabolism	4/1365	55/7206	0.0239599232472
ko00010	Glycolysis / Gluconeogenesis	22/1365	74/7206	0.0242172505909
ko03018	RNA degradation	8/1365	84/7206	0.0246155300475
ko05219	Bladder cancer	3/1365	48/7206	0.0246707206247
ko04973	Carbohydrate digestion and absorption	14/1365	42/7206	0.0273020874687
ko04932	Non-alcoholic fatty liver disease (NAFLD)	23/1365	182/7206	0.0273112506506
ko05217	Basal cell carcinoma	6/1365	68/7206	0.0293761764905
ko04113	Meiosis - yeast	6/1365	70/7206	0.0302633098957
ko05320	Autoimmune thyroid disease	1/1365	29/7206	0.0305803870756
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1365	14/7206	0.0342748714258
ko00280	Valine, leucine and isoleucine degradation	4/1365	54/7206	0.034338522351
ko05144	Malaria	3/1365	45/7206	0.0345123719268
ko00071	Fatty acid degradation	3/1365	45/7206	0.0345123719268
ko03410	Base excision repair	2/1365	38/7206	0.0349569788192
ko04115	p53 signaling pathway	7/1365	74/7206	0.0361845218558
ko04213	Longevity regulating pathway - multiple species	24/1365	86/7206	0.0377861775904
ko00230	Purine metabolism	48/1365	194/7206	0.0408766421517
ko05206	MicroRNAs in cancer	23/1365	177/7206	0.0412159152968
ko05016	Huntington's disease	29/1365	215/7206	0.0416627736921
ko05200	Pathways in cancer	76/1365	492/7206	0.0425598900989
ko05230	Central carbon metabolism in cancer	23/1365	81/7206	0.04432046374
ko04960	Aldosterone-regulated sodium reabsorption	13/1365	41/7206	0.0448490973551
ko04142	Lysosome	19/1365	151/7206	0.0457423969585
ko00040	Pentose and glucuronate interconversions	1/1365	26/7206	0.0458499367232
ko05202	Transcriptional misregulation in cancer	25/1365	188/7206	0.047340546947
ko00860	Porphyrin and chlorophyll metabolism	2/1365	34/7206	0.0492094133812