ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	203/1283	423/7206	2.29714760666e-49
ko04724	Glutamatergic synapse	93/1283	152/7206	2.15434168204e-33
ko05033	Nicotine addiction	47/1283	56/7206	4.22031505694e-27
ko04727	GABAergic synapse	68/1283	110/7206	4.91445826528e-25
ko05032	Morphine addiction	68/1283	110/7206	4.91445826528e-25
ko04713	Circadian entrainment	75/1283	136/7206	3.98970512889e-23
ko04728	Dopaminergic synapse	86/1283	185/7206	7.99184194781e-20
ko04020	Calcium signaling pathway	107/1283	265/7206	1.53085880925e-18
ko04725	Cholinergic synapse	75/1283	160/7206	1.11063440775e-17
ko04723	Retrograde endocannabinoid signaling	79/1283	175/7206	2.32836659066e-17
ko04721	Synaptic vesicle cycle	47/1283	80/7206	2.07657765529e-16
ko04024	cAMP signaling pathway	106/1283	279/7206	3.49241523747e-16
ko04911	Insulin secretion	55/1283	117/7206	2.35745390673e-13
ko04726	Serotonergic synapse	61/1283	137/7206	2.41449305859e-13
ko04744	Phototransduction	26/1283	36/7206	1.06328921964e-12
ko04742	Taste transduction	35/1283	61/7206	3.93509168557e-12
ko04921	Oxytocin signaling pathway	79/1283	209/7206	4.64182777475e-12
ko04970	Salivary secretion	45/1283	95/7206	2.64336702202e-11
ko05031	Amphetamine addiction	42/1283	91/7206	3.41659115233e-10
ko03010	Ribosome	1/1283	129/7206	3.45424628075e-10
ko04720	Long-term potentiation	42/1283	99/7206	1.12461378737e-08
ko04261	Adrenergic signaling in cardiomyocytes	70/1283	205/7206	1.37480694938e-08
ko04022	cGMP-PKG signaling pathway	72/1283	216/7206	2.14425674152e-08
ko03040	Spliceosome	4/1283	145/7206	3.22896440468e-08
ko05322	Systemic lupus erythematosus	5/1283	151/7206	6.75488130887e-08
ko04925	Aldosterone synthesis and secretion	42/1283	105/7206	8.61276817488e-08
ko05203	Viral carcinogenesis	20/1283	277/7206	3.40896255311e-07
ko04971	Gastric acid secretion	38/1283	98/7206	7.67135642417e-07
ko03013	RNA transport	8/1283	166/7206	8.83662711239e-07
ko05168	Herpes simplex infection	10/1283	182/7206	1.07732930617e-06
ko04070	Phosphatidylinositol signaling system	41/1283	112/7206	2.14115797606e-06
ko04740	Olfactory transduction	32/1283	80/7206	2.46376300899e-06
ko04110	Cell cycle	7/1283	145/7206	4.71436439532e-06
ko05030	Cocaine addiction	29/1283	73/7206	8.63799956918e-06
ko04621	NOD-like receptor signaling pathway	9/1283	157/7206	1.1574103122e-05
ko04966	Collecting duct acid secretion	14/1283	26/7206	3.41783566133e-05
ko05164	Influenza A	11/1283	167/7206	3.41826114899e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1283	74/7206	4.1433272539e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1283	79/7206	4.47574269151e-05
ko04745	Phototransduction - fly	17/1283	38/7206	0.000107529868004
ko05161	Hepatitis B	13/1283	173/7206	0.000118326738143
ko04730	Long-term depression	28/1283	78/7206	0.000133706000655
ko04972	Pancreatic secretion	36/1283	111/7206	0.000150626343747
ko04540	Gap junction	40/1283	128/7206	0.000167639833058
ko04141	Protein processing in endoplasmic reticulum	15/1283	184/7206	0.000267349754993
ko05169	Epstein-Barr virus infection	18/1283	206/7206	0.000283677823248
ko04750	Inflammatory mediator regulation of TRP channels	38/1283	122/7206	0.000288782199346
ko04924	Renin secretion	29/1283	86/7206	0.000320190601738
ko04072	Phospholipase D signaling pathway	55/1283	197/7206	0.000425646097152
ko04371	Apelin signaling pathway	50/1283	177/7206	0.000467733004427
ko00520	Amino sugar and nucleotide sugar metabolism	1/1283	55/7206	0.000531093954691
ko05162	Measles	8/1283	120/7206	0.000649181906942
ko05166	HTLV-I infection	31/1283	292/7206	0.000740891110647
ko04014	Ras signaling pathway	72/1283	279/7206	0.00075055215598
ko04710	Circadian rhythm	17/1283	43/7206	0.000855267992231
ko04922	Glucagon signaling pathway	38/1283	128/7206	0.000960283744619
ko04010	MAPK signaling pathway	80/1283	321/7206	0.00099502777385
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1283	79/7206	0.000995530778685
ko04514	Cell adhesion molecules (CAMs)	38/1283	130/7206	0.00112172300239
ko05205	Proteoglycans in cancer	29/1283	271/7206	0.00117964989757
ko05110	Vibrio cholerae infection	22/1283	63/7206	0.00127526740866
ko04060	Cytokine-cytokine receptor interaction	18/1283	191/7206	0.00146128340731
ko04120	Ubiquitin mediated proteolysis	11/1283	138/7206	0.00149762507935
ko04923	Regulation of lipolysis in adipocytes	25/1283	77/7206	0.00152020607182
ko04976	Bile secretion	26/1283	80/7206	0.00167578370338
ko05219	Bladder cancer	1/1283	48/7206	0.00185091650234
ko04360	Axon guidance	60/1283	233/7206	0.00219349253166
ko05414	Dilated cardiomyopathy	33/1283	112/7206	0.00251229670166
ko04964	Proximal tubule bicarbonate reclamation	12/1283	29/7206	0.00252544425606
ko04915	Estrogen signaling pathway	37/1283	131/7206	0.00262647187094
ko03022	Basal transcription factors	1/1283	44/7206	0.00272274368199
ko03420	Nucleotide excision repair	1/1283	46/7206	0.00286060229455
ko04270	Vascular smooth muscle contraction	42/1283	154/7206	0.00376839529597
ko04330	Notch signaling pathway	3/1283	62/7206	0.0041753436626
ko04622	RIG-I-like receptor signaling pathway	3/1283	62/7206	0.0041753436626
ko04064	NF-kappa B signaling pathway	7/1283	96/7206	0.00450345125673
ko04657	IL-17 signaling pathway	6/1283	87/7206	0.00462455747375
ko05133	Pertussis	6/1283	87/7206	0.00462455747375
ko04214	Apoptosis - fly	4/1283	72/7206	0.00464917861271
ko04217	Necroptosis	18/1283	178/7206	0.00528333463915
ko04930	Type II diabetes mellitus	18/1283	54/7206	0.00625169314416
ko04612	Antigen processing and presentation	5/1283	77/7206	0.00649881911067
ko04260	Cardiac muscle contraction	28/1283	98/7206	0.00752589618359
ko00562	Inositol phosphate metabolism	26/1283	89/7206	0.00754819256398
ko04630	Jak-STAT signaling pathway	12/1283	132/7206	0.00778695914526
ko04626	Plant-pathogen interaction	8/1283	18/7206	0.00798439481923
ko05016	Huntington's disease	24/1283	215/7206	0.0084884153402
ko05131	Shigellosis	6/1283	82/7206	0.00882091466405
ko05140	Leishmaniasis	5/1283	75/7206	0.0091253168193
ko00630	Glyoxylate and dicarboxylate metabolism	1/1283	38/7206	0.00938722330968
ko03410	Base excision repair	1/1283	38/7206	0.00938722330968
ko05222	Small cell lung cancer	7/1283	89/7206	0.0114808594474
ko04960	Aldosterone-regulated sodium reabsorption	14/1283	41/7206	0.011987412703
ko05215	Prostate cancer	10/1283	111/7206	0.0120922266262
ko05145	Toxoplasmosis	12/1283	126/7206	0.0131061216833
ko04350	TGF-beta signaling pathway	9/1283	103/7206	0.0132377575545
ko04973	Carbohydrate digestion and absorption	14/1283	42/7206	0.0137879673455
ko04510	Focal adhesion	29/1283	240/7206	0.0162837747832
ko04610	Complement and coagulation cascades	6/1283	79/7206	0.0168525464368
ko05200	Pathways in cancer	68/1283	492/7206	0.0171174436607
ko04210	Apoptosis	20/1283	180/7206	0.0174400218453
ko04620	Toll-like receptor signaling pathway	9/1283	100/7206	0.0175547024063
ko00280	Valine, leucine and isoleucine degradation	3/1283	54/7206	0.0184215655004
ko05212	Pancreatic cancer	7/1283	83/7206	0.0209039014329
ko05220	Chronic myeloid leukemia	7/1283	85/7206	0.021312300686
ko05206	MicroRNAs in cancer	20/1283	177/7206	0.0217303675508
ko01524	Platinum drug resistance	6/1283	76/7206	0.0226636551553
ko04932	Non-alcoholic fatty liver disease (NAFLD)	21/1283	182/7206	0.0238124102913
ko05217	Basal cell carcinoma	5/1283	68/7206	0.024301839325
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1283	14/7206	0.0258260351897
ko04550	Signaling pathways regulating pluripotency of stem cells	19/1283	165/7206	0.0306437427576
ko04658	Th1 and Th2 cell differentiation	9/1283	96/7206	0.0307087940655
ko04912	GnRH signaling pathway	31/1283	122/7206	0.0314508231786
ko05321	Inflammatory bowel disease (IBD)	4/1283	56/7206	0.0346287811426
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1283	100/7206	0.0352794748325
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1283	59/7206	0.038222495303
ko04113	Meiosis - yeast	6/1283	70/7206	0.0410455048844
ko03018	RNA degradation	8/1283	84/7206	0.044646631787
ko05224	Breast cancer	21/1283	174/7206	0.044820362681
ko05416	Viral myocarditis	4/1283	55/7206	0.0491460232517