ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 183/1169 423/7206 1.68340484783e-42 ko05033 Nicotine addiction 47/1169 56/7206 5.7811028833e-29 ko04724 Glutamatergic synapse 84/1169 152/7206 7.91555523169e-29 ko05032 Morphine addiction 67/1169 110/7206 1.39416891894e-26 ko04713 Circadian entrainment 72/1169 136/7206 2.50709703562e-23 ko04727 GABAergic synapse 63/1169 110/7206 5.30610538476e-23 ko04728 Dopaminergic synapse 85/1169 185/7206 6.14206632605e-22 ko04725 Cholinergic synapse 75/1169 160/7206 4.10948338739e-20 ko04721 Synaptic vesicle cycle 48/1169 80/7206 5.66319882979e-19 ko04723 Retrograde endocannabinoid signaling 77/1169 175/7206 1.39076339614e-18 ko04024 cAMP signaling pathway 99/1169 279/7206 1.5821734667e-15 ko04742 Taste transduction 37/1169 61/7206 3.96902926105e-15 ko04911 Insulin secretion 54/1169 117/7206 1.88529084809e-14 ko04744 Phototransduction 25/1169 36/7206 1.39290597936e-12 ko04020 Calcium signaling pathway 89/1169 265/7206 1.56100617494e-12 ko04726 Serotonergic synapse 56/1169 137/7206 3.21288038393e-12 ko04921 Oxytocin signaling pathway 74/1169 209/7206 6.11240123915e-12 ko03040 Spliceosome 1/1169 145/7206 3.19999294633e-10 ko04360 Axon guidance 76/1169 233/7206 3.24558301688e-10 ko04261 Adrenergic signaling in cardiomyocytes 69/1169 205/7206 4.92848720205e-10 ko05031 Amphetamine addiction 39/1169 91/7206 1.27705220338e-09 ko04740 Olfactory transduction 35/1169 80/7206 4.67037493487e-09 ko05203 Viral carcinogenesis 14/1169 277/7206 9.68117104101e-09 ko04970 Salivary secretion 38/1169 95/7206 2.08764779538e-08 ko04720 Long-term potentiation 39/1169 99/7206 2.25052902306e-08 ko05030 Cocaine addiction 31/1169 73/7206 8.26462816069e-08 ko03013 RNA transport 5/1169 166/7206 8.8240748856e-08 ko05168 Herpes simplex infection 7/1169 182/7206 2.08599688585e-07 ko04971 Gastric acid secretion 37/1169 98/7206 2.14120681e-07 ko04060 Cytokine-cytokine receptor interaction 8/1169 191/7206 2.48742109261e-07 ko04925 Aldosterone synthesis and secretion 38/1169 105/7206 6.1749779462e-07 ko05322 Systemic lupus erythematosus 5/1169 151/7206 9.08767346367e-07 ko05164 Influenza A 7/1169 167/7206 1.92561105877e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 28/1169 74/7206 7.41518261826e-06 ko04514 Cell adhesion molecules (CAMs) 41/1169 130/7206 1.11079364899e-05 ko04010 MAPK signaling pathway 82/1169 321/7206 1.24106478342e-05 ko04022 cGMP-PKG signaling pathway 60/1169 216/7206 1.30281385689e-05 ko04610 Complement and coagulation cascades 1/1169 79/7206 2.0398714962e-05 ko03008 Ribosome biogenesis in eukaryotes 1/1169 79/7206 2.0398714962e-05 ko04972 Pancreatic secretion 36/1169 111/7206 2.13756294344e-05 ko04141 Protein processing in endoplasmic reticulum 11/1169 184/7206 4.04840266407e-05 ko04976 Bile secretion 27/1169 80/7206 9.67832583781e-05 ko04621 NOD-like receptor signaling pathway 9/1169 157/7206 0.00010376585823 ko04072 Phospholipase D signaling pathway 53/1169 197/7206 0.000113757016768 ko05205 Proteoglycans in cancer 23/1169 271/7206 0.000204020619582 ko04540 Gap junction 37/1169 128/7206 0.000246415695013 ko04640 Hematopoietic cell lineage 1/1169 64/7206 0.000249810341651 ko04612 Antigen processing and presentation 2/1169 77/7206 0.000257559551244 ko04120 Ubiquitin mediated proteolysis 8/1169 138/7206 0.000268882907099 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 26/1169 79/7206 0.000289349405853 ko04966 Collecting duct acid secretion 12/1169 26/7206 0.000327735728106 ko05140 Leishmaniasis 2/1169 75/7206 0.000389111534769 ko04745 Phototransduction - fly 15/1169 38/7206 0.000493016406535 ko04730 Long-term depression 25/1169 78/7206 0.0005088441585 ko04961 Endocrine and other factor-regulated calcium reabsorption 20/1169 59/7206 0.000998129198226 ko05162 Measles 7/1169 120/7206 0.00100623408181 ko04924 Renin secretion 26/1169 86/7206 0.00102064864451 ko05169 Epstein-Barr virus infection 17/1169 206/7206 0.00103231786704 ko04070 Phosphatidylinositol signaling system 32/1169 112/7206 0.00104682962869 ko05161 Hepatitis B 13/1169 173/7206 0.00109396410267 ko04964 Proximal tubule bicarbonate reclamation 12/1169 29/7206 0.00109674488814 ko04014 Ras signaling pathway 66/1169 279/7206 0.00116292525739 ko00480 Glutathione metabolism 1/1169 55/7206 0.00134239773118 ko05414 Dilated cardiomyopathy 31/1169 112/7206 0.0017922642564 ko04064 NF-kappa B signaling pathway 5/1169 96/7206 0.00186427482836 ko00590 Arachidonic acid metabolism 1/1169 52/7206 0.00198554891833 ko04260 Cardiac muscle contraction 28/1169 98/7206 0.0020703829075 ko04923 Regulation of lipolysis in adipocytes 23/1169 77/7206 0.00265806603025 ko04110 Cell cycle 11/1169 145/7206 0.00290508399303 ko00604 Glycosphingolipid biosynthesis - ganglio series 7/1169 14/7206 0.00347439124307 ko04146 Peroxisome 5/1169 89/7206 0.00358513868196 ko04750 Inflammatory mediator regulation of TRP channels 32/1169 122/7206 0.00415186235303 ko03420 Nucleotide excision repair 1/1169 46/7206 0.00444199219096 ko04658 Th1 and Th2 cell differentiation 6/1169 96/7206 0.00499062340852 ko04657 IL-17 signaling pathway 5/1169 87/7206 0.00501591932069 ko05133 Pertussis 5/1169 87/7206 0.00501591932069 ko05110 Vibrio cholerae infection 19/1169 63/7206 0.00525542194659 ko04630 Jak-STAT signaling pathway 10/1169 132/7206 0.0056893201044 ko05321 Inflammatory bowel disease (IBD) 2/1169 56/7206 0.00571966804281 ko03022 Basal transcription factors 1/1169 44/7206 0.00668363368176 ko00071 Fatty acid degradation 1/1169 45/7206 0.00690409362169 ko04915 Estrogen signaling pathway 33/1169 131/7206 0.00802951523753 ko00280 Valine, leucine and isoleucine degradation 2/1169 54/7206 0.00842488667788 ko00240 Pyrimidine metabolism 8/1169 110/7206 0.00858045771633 ko04371 Apelin signaling pathway 42/1169 177/7206 0.00944864663786 ko05131 Shigellosis 5/1169 82/7206 0.00972109718591 ko04932 Non-alcoholic fatty liver disease (NAFLD) 17/1169 182/7206 0.0104709958121 ko05166 HTLV-I infection 32/1169 292/7206 0.0118114582784 ko04217 Necroptosis 17/1169 178/7206 0.0131417407222 ko00330 Arginine and proline metabolism 3/1169 61/7206 0.0133775485989 ko03320 PPAR signaling pathway 4/1169 69/7206 0.0135393325795 ko04622 RIG-I-like receptor signaling pathway 3/1169 62/7206 0.0138386720206 ko00980 Metabolism of xenobiotics by cytochrome P450 1/1169 40/7206 0.0155257442762 ko00260 Glycine, serine and threonine metabolism 2/1169 48/7206 0.0176430543692 ko05219 Bladder cancer 2/1169 48/7206 0.0176430543692 ko05215 Prostate cancer 9/1169 111/7206 0.0187212347654 ko05410 Hypertrophic cardiomyopathy (HCM) 25/1169 100/7206 0.0202513318889 ko00982 Drug metabolism - cytochrome P450 1/1169 37/7206 0.0227301361079 ko04210 Apoptosis 18/1169 180/7206 0.0236525911899 ko04137 Mitophagy - animal 6/1169 82/7206 0.023724791207 ko03018 RNA degradation 6/1169 84/7206 0.0241873195035 ko04015 Rap1 signaling pathway 59/1169 278/7206 0.0248639339396 ko00310 Lysine degradation 5/1169 73/7206 0.0251812269077 ko04115 p53 signaling pathway 5/1169 74/7206 0.0253311649418 ko00620 Pyruvate metabolism 2/1169 46/7206 0.0256661351039 ko04930 Type II diabetes mellitus 15/1169 54/7206 0.0262833338288 ko04620 Toll-like receptor signaling pathway 8/1169 100/7206 0.0275791508954 ko04218 Cellular senescence 18/1169 177/7206 0.029483540555 ko04142 Lysosome 15/1169 151/7206 0.0336635468877 ko04974 Protein digestion and absorption 23/1169 96/7206 0.0496263816223 ko04916 Melanogenesis 32/1169 142/7206 0.0496599643657