ko pathway ratio_in_study ratio_in_pop p_value ko05033 Nicotine addiction 37/671 56/7206 2.18630063097e-25 ko04724 Glutamatergic synapse 60/671 152/7206 4.38393654754e-24 ko04728 Dopaminergic synapse 61/671 185/7206 9.39337038661e-20 ko04727 GABAergic synapse 44/671 110/7206 3.43853409679e-18 ko05032 Morphine addiction 43/671 110/7206 2.34139072269e-17 ko04713 Circadian entrainment 48/671 136/7206 4.11589861953e-17 ko04723 Retrograde endocannabinoid signaling 55/671 175/7206 7.64230320788e-17 ko04080 Neuroactive ligand-receptor interaction 94/671 423/7206 1.51644720053e-16 ko04721 Synaptic vesicle cycle 34/671 80/7206 2.82318888366e-15 ko04725 Cholinergic synapse 48/671 160/7206 5.75330263059e-14 ko04911 Insulin secretion 37/671 117/7206 8.39820297463e-12 ko04744 Phototransduction 19/671 36/7206 3.79980215833e-11 ko04024 cAMP signaling pathway 61/671 279/7206 1.22268733868e-10 ko04921 Oxytocin signaling pathway 50/671 209/7206 1.88429206995e-10 ko04261 Adrenergic signaling in cardiomyocytes 47/671 205/7206 4.50124508163e-09 ko04726 Serotonergic synapse 36/671 137/7206 5.00822219563e-09 ko05031 Amphetamine addiction 26/671 91/7206 1.14215233163e-07 ko04720 Long-term potentiation 27/671 99/7206 1.87334515304e-07 ko04020 Calcium signaling pathway 51/671 265/7206 3.97952263598e-07 ko04514 Cell adhesion molecules (CAMs) 31/671 130/7206 6.28362518169e-07 ko04360 Axon guidance 46/671 233/7206 7.85149983976e-07 ko05030 Cocaine addiction 20/671 73/7206 6.77484552908e-06 ko04970 Salivary secretion 23/671 95/7206 1.35356758878e-05 ko04745 Phototransduction - fly 13/671 38/7206 2.1173796939e-05 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 20/671 79/7206 2.44318936136e-05 ko04742 Taste transduction 17/671 61/7206 2.59405471392e-05 ko04010 MAPK signaling pathway 53/671 321/7206 2.95585331913e-05 ko05203 Viral carcinogenesis 8/671 277/7206 3.17247715612e-05 ko05322 Systemic lupus erythematosus 2/671 151/7206 9.28537180249e-05 ko05014 Amyotrophic lateral sclerosis (ALS) 18/671 74/7206 0.000108598570071 ko03013 RNA transport 3/671 166/7206 0.000124972469004 ko05164 Influenza A 3/671 167/7206 0.000125170199625 ko04260 Cardiac muscle contraction 21/671 98/7206 0.000274721423003 ko04971 Gastric acid secretion 20/671 98/7206 0.000643709820746 ko04730 Long-term depression 17/671 78/7206 0.00067187156844 ko05168 Herpes simplex infection 5/671 182/7206 0.000694123721302 ko04964 Proximal tubule bicarbonate reclamation 9/671 29/7206 0.000904826033249 ko05166 HTLV-I infection 12/671 292/7206 0.000919024215374 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/671 14/7206 0.000995751455011 ko04022 cGMP-PKG signaling pathway 35/671 216/7206 0.00115586463092 ko04060 Cytokine-cytokine receptor interaction 6/671 191/7206 0.00141876588467 ko04120 Ubiquitin mediated proteolysis 3/671 138/7206 0.00157645848289 ko04925 Aldosterone synthesis and secretion 20/671 105/7206 0.00181962931444 ko04740 Olfactory transduction 16/671 80/7206 0.00286880846926 ko04972 Pancreatic secretion 20/671 111/7206 0.00426789501009 ko04626 Plant-pathogen interaction 6/671 18/7206 0.00445190807635 ko04621 NOD-like receptor signaling pathway 5/671 157/7206 0.00496178621051 ko05161 Hepatitis B 6/671 173/7206 0.00496255230458 ko05410 Hypertrophic cardiomyopathy (HCM) 18/671 100/7206 0.00520095209709 ko04512 ECM-receptor interaction 15/671 79/7206 0.00601323496687 ko05162 Measles 3/671 120/7206 0.00626354797019 ko04141 Protein processing in endoplasmic reticulum 7/671 184/7206 0.00651326919429 ko04966 Collecting duct acid secretion 7/671 26/7206 0.00801107040802 ko05414 Dilated cardiomyopathy 19/671 112/7206 0.00837516404384 ko05140 Leishmaniasis 1/671 75/7206 0.00888312708581 ko04630 Jak-STAT signaling pathway 4/671 132/7206 0.00924796521585 ko04961 Endocrine and other factor-regulated calcium reabsorption 12/671 59/7206 0.010270437804 ko05205 Proteoglycans in cancer 14/671 271/7206 0.0139783323892 ko04014 Ras signaling pathway 38/671 279/7206 0.0153224455801 ko04710 Circadian rhythm 9/671 43/7206 0.0157003938039 ko05016 Huntington's disease 10/671 215/7206 0.0163773844412 ko05010 Alzheimer's disease 29/671 202/7206 0.0187286418172 ko04932 Non-alcoholic fatty liver disease (NAFLD) 8/671 182/7206 0.019175748753 ko05220 Chronic myeloid leukemia 2/671 85/7206 0.0224050445669 ko00564 Glycerophospholipid metabolism 3/671 99/7206 0.0234245264775 ko04391 Hippo signaling pathway - fly 15/671 90/7206 0.0259509309869 ko00561 Glycerolipid metabolism 1/671 63/7206 0.0277173891681 ko04930 Type II diabetes mellitus 10/671 54/7206 0.0304797977414 ko05215 Prostate cancer 4/671 111/7206 0.0320154645852 ko05211 Renal cell carcinoma 3/671 96/7206 0.0325358679224 ko04064 NF-kappa B signaling pathway 3/671 96/7206 0.0325358679224 ko04371 Apelin signaling pathway 25/671 177/7206 0.0348544544226 ko05012 Parkinson's disease 7/671 155/7206 0.0354764044223 ko04924 Renin secretion 14/671 86/7206 0.0371819773599 ko04071 Sphingolipid signaling pathway 23/671 162/7206 0.0390362802571 ko04115 p53 signaling pathway 2/671 74/7206 0.044214694842 ko01524 Platinum drug resistance 2/671 76/7206 0.0446850549311 ko00240 Pyrimidine metabolism 4/671 110/7206 0.0447280824367 ko04612 Antigen processing and presentation 2/671 77/7206 0.0453547795146