ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 57/521 152/7206 2.80246108939e-27 ko04080 Neuroactive ligand-receptor interaction 92/521 423/7206 2.62786605426e-23 ko04727 GABAergic synapse 42/521 110/7206 1.13789332991e-20 ko05033 Nicotine addiction 30/521 56/7206 3.01528890521e-20 ko05032 Morphine addiction 40/521 110/7206 7.77613484875e-19 ko04721 Synaptic vesicle cycle 33/521 80/7206 1.09820631538e-17 ko04723 Retrograde endocannabinoid signaling 48/521 175/7206 1.25494110106e-16 ko04725 Cholinergic synapse 44/521 160/7206 2.25989849366e-15 ko04713 Circadian entrainment 40/521 136/7206 3.67069655858e-15 ko04728 Dopaminergic synapse 47/521 185/7206 6.79242306431e-15 ko04911 Insulin secretion 35/521 117/7206 1.17809178767e-13 ko04726 Serotonergic synapse 35/521 137/7206 1.86485303687e-11 ko04744 Phototransduction 17/521 36/7206 7.39027108329e-11 ko04024 cAMP signaling pathway 52/521 279/7206 1.08590667457e-10 ko04970 Salivary secretion 24/521 95/7206 3.75270545956e-08 ko05031 Amphetamine addiction 22/521 91/7206 3.22242163162e-07 ko04020 Calcium signaling pathway 43/521 265/7206 3.56932247026e-07 ko04921 Oxytocin signaling pathway 37/521 209/7206 3.62181849827e-07 ko05030 Cocaine addiction 19/521 73/7206 6.08895979805e-07 ko04742 Taste transduction 17/521 61/7206 8.37733831559e-07 ko04720 Long-term potentiation 22/521 99/7206 1.51496914387e-06 ko04972 Pancreatic secretion 23/521 111/7206 3.17124375755e-06 ko04971 Gastric acid secretion 21/521 98/7206 4.85953226576e-06 ko04261 Adrenergic signaling in cardiomyocytes 33/521 205/7206 1.2280750577e-05 ko04514 Cell adhesion molecules (CAMs) 24/521 130/7206 1.57744924185e-05 ko04964 Proximal tubule bicarbonate reclamation 9/521 29/7206 0.00013603940607 ko04925 Aldosterone synthesis and secretion 19/521 105/7206 0.000158401627418 ko04961 Endocrine and other factor-regulated calcium reabsorption 13/521 59/7206 0.000233915228304 ko04022 cGMP-PKG signaling pathway 31/521 216/7206 0.000237223929677 ko04745 Phototransduction - fly 10/521 38/7206 0.00026620665081 ko05203 Viral carcinogenesis 6/521 277/7206 0.000317102930185 ko05322 Systemic lupus erythematosus 1/521 151/7206 0.000328010808768 ko04740 Olfactory transduction 15/521 80/7206 0.000516868066578 ko04010 MAPK signaling pathway 40/521 321/7206 0.000570361572584 ko04120 Ubiquitin mediated proteolysis 1/521 138/7206 0.000677041019393 ko05014 Amyotrophic lateral sclerosis (ALS) 14/521 74/7206 0.000717229900116 ko05168 Herpes simplex infection 3/521 182/7206 0.00119869483902 ko04730 Long-term depression 14/521 78/7206 0.00123246282969 ko04966 Collecting duct acid secretion 7/521 26/7206 0.00194298001699 ko04540 Gap junction 19/521 128/7206 0.00268067036455 ko05034 Alcoholism 30/521 238/7206 0.00302963344837 ko03013 RNA transport 3/521 166/7206 0.00342501202648 ko05164 Influenza A 3/521 167/7206 0.00348312472222 ko05205 Proteoglycans in cancer 8/521 271/7206 0.0037680730608 ko04072 Phospholipase D signaling pathway 25/521 197/7206 0.00496672166246 ko04810 Regulation of actin cytoskeleton 8/521 264/7206 0.0049867543192 ko05110 Vibrio cholerae infection 11/521 63/7206 0.00498778154285 ko04371 Apelin signaling pathway 23/521 177/7206 0.00500129461332 ko04630 Jak-STAT signaling pathway 2/521 132/7206 0.00584816620649 ko04976 Bile secretion 13/521 80/7206 0.00689277244424 ko05166 HTLV-I infection 10/521 292/7206 0.00764474361483 ko04960 Aldosterone-regulated sodium reabsorption 8/521 41/7206 0.0080631860159 ko04924 Renin secretion 13/521 86/7206 0.00988880151998 ko04918 Thyroid hormone synthesis 13/521 86/7206 0.00988880151998 ko04062 Chemokine signaling pathway 24/521 201/7206 0.0126758957202 ko04932 Non-alcoholic fatty liver disease (NAFLD) 5/521 182/7206 0.0132155721175 ko00604 Glycosphingolipid biosynthesis - ganglio series 4/521 14/7206 0.0150832388324 ko04260 Cardiac muscle contraction 14/521 98/7206 0.0157105717957 ko04014 Ras signaling pathway 31/521 279/7206 0.0175002790888 ko04750 Inflammatory mediator regulation of TRP channels 16/521 122/7206 0.0197825774621 ko05016 Huntington's disease 7/521 215/7206 0.021863898677 ko04060 Cytokine-cytokine receptor interaction 6/521 191/7206 0.022875643224 ko04978 Mineral absorption 7/521 40/7206 0.0229158453547 ko05169 Epstein-Barr virus infection 7/521 206/7206 0.028260770111 ko04973 Carbohydrate digestion and absorption 7/521 42/7206 0.029298885602 ko04141 Protein processing in endoplasmic reticulum 6/521 184/7206 0.0303344418337 ko04510 Focal adhesion 9/521 240/7206 0.0308403149133 ko04110 Cell cycle 4/521 145/7206 0.0337770497124 ko04626 Plant-pathogen interaction 4/521 18/7206 0.036661589783 ko04270 Vascular smooth muscle contraction 18/521 154/7206 0.0394584459007 ko04070 Phosphatidylinositol signaling system 14/521 112/7206 0.0406631984848 ko05130 Pathogenic Escherichia coli infection 1/521 77/7206 0.0429533937081 ko04610 Complement and coagulation cascades 1/521 79/7206 0.0444864832654