ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	147/878	423/7206	4.24350342748e-36
ko05033	Nicotine addiction	42/878	56/7206	1.78032930511e-27
ko04724	Glutamatergic synapse	69/878	152/7206	7.36494862548e-25
ko04727	GABAergic synapse	50/878	110/7206	2.50303046147e-18
ko05032	Morphine addiction	49/878	110/7206	1.56210676292e-17
ko04723	Retrograde endocannabinoid signaling	61/878	175/7206	2.59261426949e-15
ko04713	Circadian entrainment	52/878	136/7206	4.04204643117e-15
ko04725	Cholinergic synapse	53/878	160/7206	1.90396402139e-12
ko04728	Dopaminergic synapse	58/878	185/7206	2.31530350239e-12
ko04726	Serotonergic synapse	47/878	137/7206	8.65652561784e-12
ko04742	Taste transduction	28/878	61/7206	6.02381511351e-11
ko04024	cAMP signaling pathway	73/878	279/7206	7.02250803495e-11
ko05031	Amphetamine addiction	35/878	91/7206	1.12730911714e-10
ko04976	Bile secretion	31/878	80/7206	1.06411756946e-09
ko04972	Pancreatic secretion	37/878	111/7206	3.68402137243e-09
ko04744	Phototransduction	19/878	36/7206	3.99439648276e-09
ko04721	Synaptic vesicle cycle	30/878	80/7206	4.95323763546e-09
ko04911	Insulin secretion	38/878	117/7206	5.16555056811e-09
ko04020	Calcium signaling pathway	66/878	265/7206	7.47462769844e-09
ko04921	Oxytocin signaling pathway	54/878	209/7206	3.83305296339e-08
ko05030	Cocaine addiction	27/878	73/7206	4.10603487924e-08
ko04970	Salivary secretion	31/878	95/7206	1.19434688883e-07
ko04974	Protein digestion and absorption	31/878	96/7206	1.56264509952e-07
ko04740	Olfactory transduction	27/878	80/7206	3.62983146902e-07
ko05203	Viral carcinogenesis	10/878	277/7206	7.52696972944e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	25/878	74/7206	9.61892869899e-07
ko04141	Protein processing in endoplasmic reticulum	4/878	184/7206	1.04652803713e-06
ko04720	Long-term potentiation	30/878	99/7206	1.14915678947e-06
ko04978	Mineral absorption	17/878	40/7206	1.42035977775e-06
ko04550	Signaling pathways regulating pluripotency of stem cells	3/878	165/7206	1.56695225306e-06
ko04120	Ubiquitin mediated proteolysis	2/878	138/7206	4.77020559178e-06
ko05162	Measles	1/878	120/7206	6.4100096743e-06
ko04261	Adrenergic signaling in cardiomyocytes	47/878	205/7206	1.15533909063e-05
ko05169	Epstein-Barr virus infection	7/878	206/7206	1.18873458872e-05
ko04925	Aldosterone synthesis and secretion	29/878	105/7206	1.42830715666e-05
ko04060	Cytokine-cytokine receptor interaction	6/878	191/7206	1.48960408836e-05
ko04110	Cell cycle	3/878	145/7206	1.56255860846e-05
ko05166	HTLV-I infection	14/878	292/7206	2.16084838572e-05
ko04924	Renin secretion	25/878	86/7206	3.29702551378e-05
ko04730	Long-term depression	23/878	78/7206	3.30195175999e-05
ko05168	Herpes simplex infection	6/878	182/7206	4.38786486961e-05
ko03013	RNA transport	5/878	166/7206	5.45550486399e-05
ko05164	Influenza A	6/878	167/7206	0.000167832645633
ko04971	Gastric acid secretion	25/878	98/7206	0.000247893044899
ko05161	Hepatitis B	7/878	173/7206	0.000349720707899
ko04350	TGF-beta signaling pathway	2/878	103/7206	0.000354878410446
ko04964	Proximal tubule bicarbonate reclamation	11/878	29/7206	0.000355334156826
ko04260	Cardiac muscle contraction	24/878	98/7206	0.000824808498253
ko04142	Lysosome	6/878	151/7206	0.000915238532489
ko04630	Jak-STAT signaling pathway	5/878	132/7206	0.00116378206575
ko04932	Non-alcoholic fatty liver disease (NAFLD)	9/878	182/7206	0.00121602940351
ko04621	NOD-like receptor signaling pathway	7/878	157/7206	0.0012436265555
ko00350	Tyrosine metabolism	11/878	33/7206	0.00125537296792
ko04610	Complement and coagulation cascades	20/878	79/7206	0.00136494725798
ko04217	Necroptosis	9/878	178/7206	0.00164243104384
ko02010	ABC transporters	12/878	39/7206	0.00168145369923
ko04975	Fat digestion and absorption	11/878	35/7206	0.00215249662438
ko05220	Chronic myeloid leukemia	2/878	85/7206	0.00227162796571
ko00190	Oxidative phosphorylation	5/878	127/7206	0.00229212106244
ko00360	Phenylalanine metabolism	7/878	17/7206	0.00250420737661
ko04514	Cell adhesion molecules (CAMs)	28/878	130/7206	0.00253485881024
ko04150	mTOR signaling pathway	10/878	184/7206	0.00281916437757
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	19/878	79/7206	0.00284483353176
ko04977	Vitamin digestion and absorption	8/878	22/7206	0.00312707109351
ko05205	Proteoglycans in cancer	18/878	271/7206	0.00320050782768
ko04137	Mitophagy - animal	2/878	82/7206	0.00331520011876
ko00830	Retinol metabolism	12/878	42/7206	0.00336744172465
ko04614	Renin-angiotensin system	7/878	18/7206	0.00367240156112
ko00950	Isoquinoline alkaloid biosynthesis	5/878	10/7206	0.00394753850487
ko05211	Renal cell carcinoma	3/878	96/7206	0.00401166770654
ko04022	cGMP-PKG signaling pathway	41/878	216/7206	0.00406096362334
ko04961	Endocrine and other factor-regulated calcium reabsorption	15/878	59/7206	0.0043111767938
ko04668	TNF signaling pathway	5/878	120/7206	0.00440226032669
ko04612	Antigen processing and presentation	2/878	77/7206	0.00474562256394
ko03008	Ribosome biogenesis in eukaryotes	2/878	79/7206	0.00483823808453
ko04218	Cellular senescence	10/878	177/7206	0.00497229189906
ko04140	Autophagy - animal	9/878	164/7206	0.00528802362598
ko04111	Cell cycle - yeast	3/878	90/7206	0.00545539776566
ko04144	Endocytosis	26/878	342/7206	0.00657263693326
ko00380	Tryptophan metabolism	13/878	50/7206	0.00712692481644
ko04750	Inflammatory mediator regulation of TRP channels	25/878	122/7206	0.00758363010495
ko05322	Systemic lupus erythematosus	8/878	151/7206	0.00767766852759
ko05215	Prostate cancer	5/878	111/7206	0.00825843794181
ko04010	MAPK signaling pathway	55/878	321/7206	0.00853885486911
ko04540	Gap junction	26/878	128/7206	0.00878918874702
ko05200	Pathways in cancer	42/878	492/7206	0.00997903223741
ko04214	Apoptosis - fly	2/878	72/7206	0.0100072450493
ko03018	RNA degradation	3/878	84/7206	0.0109521148134
ko05152	Tuberculosis	12/878	187/7206	0.0123139476052
ko04390	Hippo signaling pathway	12/878	188/7206	0.0124004780817
ko04973	Carbohydrate digestion and absorption	11/878	42/7206	0.0141511418494
ko05016	Huntington's disease	15/878	215/7206	0.014784797496
ko03015	mRNA surveillance pathway	4/878	93/7206	0.0157414933867
ko04626	Plant-pathogen interaction	6/878	18/7206	0.0163664657759
ko04011	MAPK signaling pathway - yeast	1/878	53/7206	0.0178684901349
ko05414	Dilated cardiomyopathy	22/878	112/7206	0.0195820503368
ko00250	Alanine, aspartate and glutamate metabolism	10/878	38/7206	0.0203314956638
ko04745	Phototransduction - fly	10/878	38/7206	0.0203314956638
ko04210	Apoptosis	12/878	180/7206	0.0204404197022
ko00604	Glycosphingolipid biosynthesis - ganglio series	5/878	14/7206	0.0206806325641
ko05410	Hypertrophic cardiomyopathy (HCM)	20/878	100/7206	0.0208073559444
ko04510	Focal adhesion	18/878	240/7206	0.0209645153479
ko00910	Nitrogen metabolism	6/878	19/7206	0.0215145144197
ko04068	FoxO signaling pathway	11/878	167/7206	0.0225997733726
ko04933	AGE-RAGE signaling pathway in diabetic complications	8/878	135/7206	0.0231533122208
ko04660	T cell receptor signaling pathway	7/878	124/7206	0.0254492011921
ko00340	Histidine metabolism	7/878	25/7206	0.0259500242097
ko00120	Primary bile acid biosynthesis	6/878	20/7206	0.0276534618896
ko04330	Notch signaling pathway	2/878	62/7206	0.0295176193737
ko04657	IL-17 signaling pathway	4/878	87/7206	0.0302132754344
ko04115	p53 signaling pathway	3/878	74/7206	0.0303039733737
ko00983	Drug metabolism - other enzymes	10/878	42/7206	0.0305801337033
ko03420	Nucleotide excision repair	1/878	46/7206	0.038221191707
ko05145	Toxoplasmosis	8/878	126/7206	0.0395613027783
ko05212	Pancreatic cancer	4/878	83/7206	0.0409765689913
ko04113	Meiosis - yeast	3/878	70/7206	0.0418967703917
ko05202	Transcriptional misregulation in cancer	14/878	188/7206	0.042032266559
ko04918	Thyroid hormone synthesis	17/878	86/7206	0.0441516673599
ko00230	Purine metabolism	33/878	194/7206	0.0445112532545
ko05012	Parkinson's disease	11/878	155/7206	0.0473803245135
ko05206	MicroRNAs in cancer	13/878	177/7206	0.0473896188755