ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	202/1182	423/7206	6.85059058169e-55
ko05033	Nicotine addiction	50/1182	56/7206	2.72836468491e-33
ko04724	Glutamatergic synapse	87/1182	152/7206	5.22430294145e-31
ko05032	Morphine addiction	68/1182	110/7206	3.19950617164e-27
ko04727	GABAergic synapse	67/1182	110/7206	2.72833241244e-26
ko04713	Circadian entrainment	76/1182	136/7206	2.87950571712e-26
ko04728	Dopaminergic synapse	88/1182	185/7206	1.20502158683e-23
ko04725	Cholinergic synapse	76/1182	160/7206	1.67250186637e-20
ko04024	cAMP signaling pathway	105/1182	279/7206	2.2154496388e-18
ko04723	Retrograde endocannabinoid signaling	77/1182	175/7206	2.72208204835e-18
ko04742	Taste transduction	40/1182	61/7206	7.91077900464e-18
ko04744	Phototransduction	29/1182	36/7206	3.27722422594e-17
ko04721	Synaptic vesicle cycle	46/1182	80/7206	5.1743051235e-17
ko04740	Olfactory transduction	44/1182	80/7206	2.39734552812e-15
ko04726	Serotonergic synapse	61/1182	137/7206	5.05184077463e-15
ko04911	Insulin secretion	55/1182	117/7206	6.53059767392e-15
ko04020	Calcium signaling pathway	92/1182	265/7206	1.31093335434e-13
ko04261	Adrenergic signaling in cardiomyocytes	73/1182	205/7206	1.05188005703e-11
ko04921	Oxytocin signaling pathway	73/1182	209/7206	3.23693716578e-11
ko05031	Amphetamine addiction	41/1182	91/7206	1.02279707702e-10
ko04720	Long-term potentiation	43/1182	99/7206	1.53801164223e-10
ko03040	Spliceosome	1/1182	145/7206	1.92402901763e-10
ko05203	Viral carcinogenesis	12/1182	277/7206	4.33200561827e-10
ko04970	Salivary secretion	39/1182	95/7206	7.83729615131e-09
ko05030	Cocaine addiction	31/1182	73/7206	1.07269071542e-07
ko04060	Cytokine-cytokine receptor interaction	8/1182	191/7206	1.69017739099e-07
ko04925	Aldosterone synthesis and secretion	39/1182	105/7206	3.2598077125e-07
ko05322	Systemic lupus erythematosus	5/1182	151/7206	5.81848051028e-07
ko04971	Gastric acid secretion	36/1182	98/7206	1.2233883577e-06
ko03013	RNA transport	7/1182	166/7206	1.950884869e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1182	74/7206	2.05397857723e-06
ko05168	Herpes simplex infection	9/1182	182/7206	3.49108386399e-06
ko04120	Ubiquitin mediated proteolysis	5/1182	138/7206	3.87305331137e-06
ko05164	Influenza A	8/1182	167/7206	6.30017836056e-06
ko04745	Phototransduction - fly	18/1182	38/7206	8.07678441128e-06
ko04360	Axon guidance	64/1182	233/7206	1.3393955756e-05
ko04514	Cell adhesion molecules (CAMs)	41/1182	130/7206	1.93692469419e-05
ko04972	Pancreatic secretion	36/1182	111/7206	2.51611002709e-05
ko04621	NOD-like receptor signaling pathway	8/1182	157/7206	2.57825091453e-05
ko04141	Protein processing in endoplasmic reticulum	11/1182	184/7206	2.82960734564e-05
ko04010	MAPK signaling pathway	81/1182	321/7206	3.84831241004e-05
ko04730	Long-term depression	27/1182	78/7206	7.64745612396e-05
ko04022	cGMP-PKG signaling pathway	58/1182	216/7206	7.70887471982e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1182	79/7206	9.26182931454e-05
ko04976	Bile secretion	27/1182	80/7206	0.000113596648184
ko04260	Cardiac muscle contraction	31/1182	98/7206	0.000160967162751
ko04610	Complement and coagulation cascades	2/1182	79/7206	0.00017230284423
ko03008	Ribosome biogenesis in eukaryotes	2/1182	79/7206	0.00017230284423
ko04924	Renin secretion	28/1182	86/7206	0.000188503535219
ko05162	Measles	6/1182	120/7206	0.000249138438336
ko05140	Leishmaniasis	2/1182	75/7206	0.00025349271975
ko04072	Phospholipase D signaling pathway	52/1182	197/7206	0.000280703653131
ko05205	Proteoglycans in cancer	24/1182	271/7206	0.000309329033599
ko05169	Epstein-Barr virus infection	16/1182	206/7206	0.000368583556784
ko04110	Cell cycle	9/1182	145/7206	0.000377618080328
ko04540	Gap junction	37/1182	128/7206	0.000393783833566
ko03018	RNA degradation	3/1182	84/7206	0.000500935795437
ko04750	Inflammatory mediator regulation of TRP channels	35/1182	122/7206	0.000734615854594
ko05166	HTLV-I infection	28/1182	292/7206	0.000892468869738
ko04978	Mineral absorption	15/1182	40/7206	0.00104757474583
ko04964	Proximal tubule bicarbonate reclamation	12/1182	29/7206	0.00121298307973
ko04064	NF-kappa B signaling pathway	5/1182	96/7206	0.00127697263941
ko00520	Amino sugar and nucleotide sugar metabolism	1/1182	55/7206	0.00137637392169
ko04966	Collecting duct acid secretion	11/1182	26/7206	0.00155780357909
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/1182	182/7206	0.00158787261294
ko04014	Ras signaling pathway	65/1182	279/7206	0.0022279995801
ko05414	Dilated cardiomyopathy	31/1182	112/7206	0.0027470295299
ko04070	Phosphatidylinositol signaling system	31/1182	112/7206	0.0027470295299
ko04146	Peroxisome	5/1182	89/7206	0.00357254723897
ko03420	Nucleotide excision repair	1/1182	46/7206	0.00441073239519
ko05161	Hepatitis B	15/1182	173/7206	0.00472576056729
ko04612	Antigen processing and presentation	4/1182	77/7206	0.00484647873186
ko04658	Th1 and Th2 cell differentiation	6/1182	96/7206	0.00501518274488
ko04657	IL-17 signaling pathway	5/1182	87/7206	0.00506087381378
ko05110	Vibrio cholerae infection	19/1182	63/7206	0.00566929210062
ko00480	Glutathione metabolism	2/1182	55/7206	0.00566953283933
ko05321	Inflammatory bowel disease (IBD)	2/1182	56/7206	0.00572462290304
ko00240	Pyrimidine metabolism	8/1182	110/7206	0.00626300007713
ko04640	Hematopoietic cell lineage	3/1182	64/7206	0.00645496484479
ko03022	Basal transcription factors	1/1182	44/7206	0.00670289521076
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1182	59/7206	0.00696589309243
ko05144	Malaria	1/1182	45/7206	0.00704651048804
ko00071	Fatty acid degradation	1/1182	45/7206	0.00704651048804
ko04915	Estrogen signaling pathway	33/1182	131/7206	0.00858840733201
ko04622	RIG-I-like receptor signaling pathway	3/1182	62/7206	0.00920459043852
ko04214	Apoptosis - fly	4/1182	72/7206	0.00965954344796
ko05131	Shigellosis	5/1182	82/7206	0.00984667775646
ko00310	Lysine degradation	4/1182	73/7206	0.0099332224165
ko04371	Apelin signaling pathway	42/1182	177/7206	0.0100467443945
ko04217	Necroptosis	17/1182	178/7206	0.01024597006
ko00590	Arachidonic acid metabolism	2/1182	52/7206	0.0127236694278
ko05133	Pertussis	6/1182	87/7206	0.0127805281617
ko00330	Arginine and proline metabolism	3/1182	61/7206	0.0135589500931
ko01200	Carbon metabolism	11/1182	128/7206	0.0153574328072
ko05418	Fluid shear stress and atherosclerosis	17/1182	173/7206	0.0165242056091
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1182	14/7206	0.0175933464232
ko00260	Glycine, serine and threonine metabolism	2/1182	48/7206	0.0175999903656
ko04140	Autophagy - animal	16/1182	164/7206	0.0185936856924
ko04626	Plant-pathogen interaction	7/1182	18/7206	0.018860244747
ko05016	Huntington's disease	23/1182	215/7206	0.019405600351
ko04620	Toll-like receptor signaling pathway	8/1182	100/7206	0.0202002999548
ko04218	Cellular senescence	18/1182	177/7206	0.0232801858441
ko04115	p53 signaling pathway	5/1182	74/7206	0.0255938675077
ko00280	Valine, leucine and isoleucine degradation	3/1182	54/7206	0.0263822102011
ko04974	Protein digestion and absorption	24/1182	96/7206	0.0263829493496
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1182	100/7206	0.0283277389522
ko04923	Regulation of lipolysis in adipocytes	20/1182	77/7206	0.0294164894174
ko04350	TGF-beta signaling pathway	9/1182	103/7206	0.0318581029134
ko04210	Apoptosis	19/1182	180/7206	0.0319213935777
ko04668	TNF signaling pathway	11/1182	120/7206	0.0335674941261
ko00860	Porphyrin and chlorophyll metabolism	1/1182	34/7206	0.0335916067967
ko04912	GnRH signaling pathway	29/1182	122/7206	0.0350868837528
ko04270	Vascular smooth muscle contraction	35/1182	154/7206	0.0365003713763
ko05215	Prostate cancer	10/1182	111/7206	0.037618308433
ko05145	Toxoplasmosis	12/1182	126/7206	0.0381774043636
ko04722	Neurotrophin signaling pathway	36/1182	160/7206	0.0400219119172
ko00562	Inositol phosphate metabolism	22/1182	89/7206	0.0424857460816
ko01524	Platinum drug resistance	6/1182	76/7206	0.0426846083884
ko04015	Rap1 signaling pathway	58/1182	278/7206	0.0470460869964
ko04711	Circadian rhythm - fly	5/1182	13/7206	0.0480108336377