ko pathway ratio_in_study ratio_in_pop p_value ko00120 Primary bile acid biosynthesis 10/606 20/7206 1.39837825708e-06 ko04710 Circadian rhythm 14/606 43/7206 6.00021195171e-06 ko04060 Cytokine-cytokine receptor interaction 35/606 191/7206 8.13700044147e-06 ko04650 Natural killer cell mediated cytotoxicity 21/606 97/7206 4.15045488033e-05 ko04110 Cell cycle 1/606 145/7206 5.99271286328e-05 ko03013 RNA transport 2/606 166/7206 9.70675002076e-05 ko00350 Tyrosine metabolism 10/606 33/7206 0.000255896773688 ko03010 Ribosome 1/606 129/7206 0.000297956664957 ko04137 Mitophagy - animal 17/606 82/7206 0.000381210955494 ko03040 Spliceosome 2/606 145/7206 0.000432183229264 ko03320 PPAR signaling pathway 15/606 69/7206 0.000488317303845 ko00950 Isoquinoline alkaloid biosynthesis 5/606 10/7206 0.00072918969087 ko04022 cGMP-PKG signaling pathway 32/606 216/7206 0.00161713285059 ko00360 Phenylalanine metabolism 6/606 17/7206 0.00190632351749 ko00051 Fructose and mannose metabolism 10/606 42/7206 0.00203786009665 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 3/606 4/7206 0.0022195329259 ko04070 Phosphatidylinositol signaling system 19/606 112/7206 0.00288025487802 ko04711 Circadian rhythm - fly 5/606 13/7206 0.00300832869882 ko00590 Arachidonic acid metabolism 11/606 52/7206 0.00338395178442 ko00592 alpha-Linolenic acid metabolism 6/606 19/7206 0.00361381669848 ko04630 Jak-STAT signaling pathway 21/606 132/7206 0.00387969298872 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 3/606 5/7206 0.00520195958571 ko05203 Viral carcinogenesis 11/606 277/7206 0.00539668472288 ko00561 Glycerolipid metabolism 12/606 63/7206 0.00556172577723 ko04072 Phospholipase D signaling pathway 28/606 197/7206 0.0057339769175 ko05034 Alcoholism 9/606 238/7206 0.00603942721577 ko05321 Inflammatory bowel disease (IBD) 11/606 56/7206 0.00613752191349 ko05322 Systemic lupus erythematosus 4/606 151/7206 0.00689162155795 ko04621 NOD-like receptor signaling pathway 23/606 157/7206 0.00811625632622 ko04144 Endocytosis 16/606 342/7206 0.00912281614971 ko04068 FoxO signaling pathway 24/606 167/7206 0.0101247667947 ko04672 Intestinal immune network for IgA production 8/606 37/7206 0.0103352905217 ko04146 Peroxisome 15/606 89/7206 0.0103942749428 ko04380 Osteoclast differentiation 20/606 134/7206 0.0108927782856 ko05224 Breast cancer 6/606 174/7206 0.012446286109 ko04921 Oxytocin signaling pathway 28/606 209/7206 0.0153131229267 ko04064 NF-kappa B signaling pathway 15/606 96/7206 0.0156371690236 ko04390 Hippo signaling pathway 7/606 188/7206 0.0158544834908 ko00140 Steroid hormone biosynthesis 8/606 41/7206 0.0190204112416 ko05323 Rheumatoid arthritis 14/606 89/7206 0.0194366385884 ko04640 Hematopoietic cell lineage 11/606 64/7206 0.0201717512698 ko04660 T cell receptor signaling pathway 18/606 124/7206 0.0208039879873 ko04610 Complement and coagulation cascades 13/606 79/7206 0.0215962320545 ko04020 Calcium signaling pathway 33/606 265/7206 0.0232218501602 ko04611 Platelet activation 22/606 163/7206 0.0305721831367 ko00982 Drug metabolism - cytochrome P450 7/606 37/7206 0.0321134558153 ko00591 Linoleic acid metabolism 5/606 22/7206 0.0327534160819 ko04111 Cell cycle - yeast 2/606 90/7206 0.0328166420662 ko00330 Arginine and proline metabolism 10/606 61/7206 0.0341952344682 ko05340 Primary immunodeficiency 6/606 30/7206 0.0359201184514 ko04745 Phototransduction - fly 7/606 38/7206 0.0366202157527 ko04670 Leukocyte transendothelial migration 20/606 151/7206 0.0372754752066 ko00643 Styrene degradation 2/606 4/7206 0.037781514389 ko04658 Th1 and Th2 cell differentiation 14/606 96/7206 0.039173431068 ko04136 Autophagy - other 6/606 31/7206 0.0414953394089 ko02010 ABC transporters 7/606 39/7206 0.0415247673591 ko04120 Ubiquitin mediated proteolysis 5/606 138/7206 0.0423896952975 ko04930 Type II diabetes mellitus 9/606 54/7206 0.0430972478279 ko05217 Basal cell carcinoma 1/606 68/7206 0.0434044733596 ko00564 Glycerophospholipid metabolism 14/606 99/7206 0.0448225861996 ko00220 Arginine biosynthesis 5/606 24/7206 0.0460435552812 ko04350 TGF-beta signaling pathway 3/606 103/7206 0.046526317859 ko04550 Signaling pathways regulating pluripotency of stem cells 7/606 165/7206 0.0472455342291 ko04925 Aldosterone synthesis and secretion 15/606 105/7206 0.0480832195754 ko04659 Th17 cell differentiation 15/606 106/7206 0.049155589498