ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	166/974	423/7206	8.79421901004e-43
ko04724	Glutamatergic synapse	92/974	152/7206	1.10954944302e-42
ko05033	Nicotine addiction	49/974	56/7206	8.0099759525e-36
ko04727	GABAergic synapse	69/974	110/7206	1.44622287307e-33
ko05032	Morphine addiction	68/974	110/7206	1.62970025955e-32
ko04713	Circadian entrainment	75/974	136/7206	4.40013273483e-31
ko04728	Dopaminergic synapse	84/974	185/7206	8.03798734053e-27
ko04725	Cholinergic synapse	76/974	160/7206	6.66935687124e-26
ko04723	Retrograde endocannabinoid signaling	79/974	175/7206	4.60618634009e-25
ko04911	Insulin secretion	57/974	117/7206	2.39757920787e-20
ko04024	cAMP signaling pathway	94/974	279/7206	1.14518464305e-18
ko04726	Serotonergic synapse	58/974	137/7206	4.76776640236e-17
ko04921	Oxytocin signaling pathway	73/974	209/7206	1.1952434385e-15
ko04261	Adrenergic signaling in cardiomyocytes	72/974	205/7206	1.35492640667e-15
ko04020	Calcium signaling pathway	85/974	265/7206	2.05511977639e-15
ko04721	Synaptic vesicle cycle	40/974	80/7206	3.94404710104e-15
ko04742	Taste transduction	34/974	61/7206	6.78391518116e-15
ko05031	Amphetamine addiction	41/974	91/7206	1.6298055292e-13
ko04720	Long-term potentiation	42/974	99/7206	1.01067138968e-12
ko04744	Phototransduction	23/974	36/7206	3.23468938342e-12
ko04970	Salivary secretion	39/974	95/7206	2.26234124653e-11
ko05030	Cocaine addiction	33/974	73/7206	3.52101400858e-11
ko04971	Gastric acid secretion	39/974	98/7206	7.03370652974e-11
ko04925	Aldosterone synthesis and secretion	40/974	105/7206	1.95635501327e-10
ko04972	Pancreatic secretion	39/974	111/7206	5.07053702467e-09
ko04010	MAPK signaling pathway	81/974	321/7206	8.05976640665e-09
ko03040	Spliceosome	1/974	145/7206	2.28981725841e-08
ko04360	Axon guidance	61/974	233/7206	1.51333613993e-07
ko04072	Phospholipase D signaling pathway	53/974	197/7206	4.08226684332e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	27/974	74/7206	4.95743284321e-07
ko05203	Viral carcinogenesis	13/974	277/7206	1.50070927062e-06
ko04060	Cytokine-cytokine receptor interaction	6/974	191/7206	1.51982013803e-06
ko04022	cGMP-PKG signaling pathway	55/974	216/7206	2.23834649583e-06
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/974	59/7206	3.72852236811e-06
ko04730	Long-term depression	26/974	78/7206	5.69782291205e-06
ko05322	Systemic lupus erythematosus	4/974	151/7206	5.98780838609e-06
ko04915	Estrogen signaling pathway	37/974	131/7206	7.06030609451e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/974	79/7206	7.42068824759e-06
ko05414	Dilated cardiomyopathy	33/974	112/7206	8.49606597501e-06
ko04740	Olfactory transduction	26/974	80/7206	9.60591294809e-06
ko05168	Herpes simplex infection	7/974	182/7206	2.20409003574e-05
ko03013	RNA transport	6/974	166/7206	2.67044475435e-05
ko04260	Cardiac muscle contraction	29/974	98/7206	3.28692275964e-05
ko04540	Gap junction	35/974	128/7206	3.43144135027e-05
ko04514	Cell adhesion molecules (CAMs)	35/974	130/7206	4.16859103886e-05
ko04750	Inflammatory mediator regulation of TRP channels	32/974	122/7206	0.000145537122662
ko04371	Apelin signaling pathway	42/974	177/7206	0.000199399261756
ko03008	Ribosome biogenesis in eukaryotes	1/974	79/7206	0.00020383926679
ko04745	Phototransduction - fly	14/974	38/7206	0.000254362903362
ko04612	Antigen processing and presentation	1/974	77/7206	0.000307718295119
ko04918	Thyroid hormone synthesis	24/974	86/7206	0.000359992553243
ko04976	Bile secretion	23/974	80/7206	0.000369473679798
ko04070	Phosphatidylinositol signaling system	29/974	112/7206	0.000398521107101
ko04141	Protein processing in endoplasmic reticulum	10/974	184/7206	0.000618739767061
ko04912	GnRH signaling pathway	30/974	122/7206	0.000768816135576
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/974	14/7206	0.00116382715373
ko04640	Hematopoietic cell lineage	1/974	64/7206	0.00153047337067
ko04916	Melanogenesis	33/974	142/7206	0.00169695268071
ko04924	Renin secretion	22/974	86/7206	0.00228011297269
ko05164	Influenza A	10/974	167/7206	0.00267563310632
ko04621	NOD-like receptor signaling pathway	9/974	157/7206	0.00287653732457
ko04110	Cell cycle	8/974	145/7206	0.00293905533705
ko04062	Chemokine signaling pathway	42/974	201/7206	0.00322495257275
ko04964	Proximal tubule bicarbonate reclamation	10/974	29/7206	0.00341486266484
ko04923	Regulation of lipolysis in adipocytes	20/974	77/7206	0.00360985414735
ko03018	RNA degradation	3/974	84/7206	0.00361142700396
ko04142	Lysosome	9/974	151/7206	0.00374030714206
ko00515	Mannose type O-glycan biosynthesis	9/974	25/7206	0.00389539451927
ko04932	Non-alcoholic fatty liver disease (NAFLD)	12/974	182/7206	0.00406668482657
ko04930	Type II diabetes mellitus	15/974	54/7206	0.00457815238159
ko05321	Inflammatory bowel disease (IBD)	1/974	56/7206	0.00509800602146
ko04015	Rap1 signaling pathway	54/974	278/7206	0.00532539192735
ko04014	Ras signaling pathway	54/974	279/7206	0.00544235791437
ko04270	Vascular smooth muscle contraction	33/974	154/7206	0.00586605484938
ko05034	Alcoholism	47/974	238/7206	0.00666101213053
ko04146	Peroxisome	4/974	89/7206	0.00772966646691
ko04114	Oocyte meiosis	30/974	139/7206	0.00804628343603
ko04350	TGF-beta signaling pathway	5/974	103/7206	0.00812934616643
ko04960	Aldosterone-regulated sodium reabsorption	12/974	41/7206	0.00892564430463
ko05162	Measles	7/974	120/7206	0.010051035203
ko04973	Carbohydrate digestion and absorption	12/974	42/7206	0.0100583718152
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/974	15/7206	0.0101351882099
ko00240	Pyrimidine metabolism	6/974	110/7206	0.0106347307043
ko05205	Proteoglycans in cancer	23/974	271/7206	0.0111735030475
ko05410	Hypertrophic cardiomyopathy (HCM)	23/974	100/7206	0.0112301605064
ko00190	Oxidative phosphorylation	8/974	127/7206	0.0126299828861
ko05169	Epstein-Barr virus infection	16/974	206/7206	0.0127325207192
ko00330	Arginine and proline metabolism	2/974	61/7206	0.0135112155385
ko04217	Necroptosis	13/974	178/7206	0.0139841477214
ko05016	Huntington's disease	17/974	215/7206	0.0145711918935
ko04064	NF-kappa B signaling pathway	5/974	96/7206	0.0150564136749
ko05231	Choline metabolism in cancer	28/974	134/7206	0.0152104731214
ko03420	Nucleotide excision repair	1/974	46/7206	0.0164947707656
ko00260	Glycine, serine and threonine metabolism	1/974	48/7206	0.0171926535461
ko04630	Jak-STAT signaling pathway	9/974	132/7206	0.0203061604321
ko01212	Fatty acid metabolism	2/974	60/7206	0.0204701603741
ko03320	PPAR signaling pathway	3/974	69/7206	0.020604329041
ko04137	Mitophagy - animal	4/974	82/7206	0.0212981754897
ko04711	Circadian rhythm - fly	5/974	13/7206	0.0225136946222
ko05110	Vibrio cholerae infection	15/974	63/7206	0.0245479398653
ko00071	Fatty acid degradation	1/974	45/7206	0.0254254448794
ko04213	Longevity regulating pathway - multiple species	19/974	86/7206	0.0255448704636
ko01200	Carbon metabolism	9/974	128/7206	0.0265569346097
ko00280	Valine, leucine and isoleucine degradation	2/974	54/7206	0.0278341329761
ko00480	Glutathione metabolism	2/974	55/7206	0.0279127470988
ko04120	Ubiquitin mediated proteolysis	10/974	138/7206	0.0315279725092
ko05145	Toxoplasmosis	9/974	126/7206	0.0346532463023
ko04722	Neurotrophin signaling pathway	31/974	160/7206	0.0347020799147
ko00980	Metabolism of xenobiotics by cytochrome P450	1/974	40/7206	0.0359443388446
ko04115	p53 signaling pathway	4/974	74/7206	0.0392193493228
ko05140	Leishmaniasis	4/974	75/7206	0.039678351852
ko04622	RIG-I-like receptor signaling pathway	3/974	62/7206	0.0403271755579
ko04210	Apoptosis	15/974	180/7206	0.0458866257151
ko04071	Sphingolipid signaling pathway	31/974	162/7206	0.047012948861
ko04012	ErbB signaling pathway	22/974	109/7206	0.0474248117141
ko00512	Mucin type O-glycan biosynthesis	8/974	29/7206	0.048799878414