ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	198/1146	423/7206	2.57675594892e-54
ko04724	Glutamatergic synapse	87/1146	152/7206	4.68181516655e-32
ko05033	Nicotine addiction	48/1146	56/7206	7.81165460285e-31
ko05032	Morphine addiction	67/1146	110/7206	4.15756150973e-27
ko04713	Circadian entrainment	72/1146	136/7206	7.28041694992e-24
ko04727	GABAergic synapse	62/1146	110/7206	1.27922117899e-22
ko04728	Dopaminergic synapse	84/1146	185/7206	7.36578732421e-22
ko04721	Synaptic vesicle cycle	48/1146	80/7206	2.40837488965e-19
ko04725	Cholinergic synapse	73/1146	160/7206	2.82746549477e-19
ko04024	cAMP signaling pathway	104/1146	279/7206	6.93382920137e-19
ko04723	Retrograde endocannabinoid signaling	76/1146	175/7206	1.80223208649e-18
ko04020	Calcium signaling pathway	99/1146	265/7206	4.41354796494e-18
ko04742	Taste transduction	38/1146	61/7206	2.3627709284e-16
ko04911	Insulin secretion	55/1146	117/7206	1.64238727544e-15
ko04921	Oxytocin signaling pathway	76/1146	209/7206	2.96143666e-13
ko04726	Serotonergic synapse	57/1146	137/7206	3.56098282069e-13
ko04261	Adrenergic signaling in cardiomyocytes	71/1146	205/7206	2.13131342867e-11
ko05031	Amphetamine addiction	41/1146	91/7206	3.75542096836e-11
ko04744	Phototransduction	23/1146	36/7206	1.00350106557e-10
ko04970	Salivary secretion	41/1146	95/7206	1.96765342155e-10
ko04720	Long-term potentiation	42/1146	99/7206	2.27920545966e-10
ko03040	Spliceosome	1/1146	145/7206	5.17411595903e-10
ko04360	Axon guidance	72/1146	233/7206	5.30156169032e-09
ko04740	Olfactory transduction	34/1146	80/7206	1.13590071075e-08
ko05030	Cocaine addiction	31/1146	73/7206	5.15789752174e-08
ko05168	Herpes simplex infection	6/1146	182/7206	8.44662478886e-08
ko05203	Viral carcinogenesis	15/1146	277/7206	8.57084245594e-08
ko04022	cGMP-PKG signaling pathway	65/1146	216/7206	1.1915457958e-07
ko04925	Aldosterone synthesis and secretion	38/1146	105/7206	2.83181319057e-07
ko04971	Gastric acid secretion	36/1146	98/7206	4.03943235273e-07
ko04060	Cytokine-cytokine receptor interaction	8/1146	191/7206	5.53149476915e-07
ko05322	Systemic lupus erythematosus	5/1146	151/7206	1.36015098695e-06
ko03013	RNA transport	7/1146	166/7206	2.83066848054e-06
ko05164	Influenza A	7/1146	167/7206	2.83276225508e-06
ko04010	MAPK signaling pathway	82/1146	321/7206	5.11317728473e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1146	74/7206	6.23194660329e-06
ko04621	NOD-like receptor signaling pathway	7/1146	157/7206	1.20305407827e-05
ko04141	Protein processing in endoplasmic reticulum	10/1146	184/7206	1.48439618747e-05
ko04514	Cell adhesion molecules (CAMs)	40/1146	130/7206	1.68641574517e-05
ko04924	Renin secretion	29/1146	86/7206	3.85401525563e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1146	79/7206	6.39853953693e-05
ko04745	Phototransduction - fly	16/1146	38/7206	0.000102976440455
ko04972	Pancreatic secretion	34/1146	111/7206	0.000106957292859
ko04260	Cardiac muscle contraction	31/1146	98/7206	0.000120373188551
ko04120	Ubiquitin mediated proteolysis	7/1146	138/7206	0.000136598279256
ko05205	Proteoglycans in cancer	22/1146	271/7206	0.000176257046265
ko04540	Gap junction	37/1146	128/7206	0.000199742324508
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1146	59/7206	0.000202349441987
ko03008	Ribosome biogenesis in eukaryotes	2/1146	79/7206	0.000268017576886
ko05169	Epstein-Barr virus infection	15/1146	206/7206	0.000307834218988
ko04070	Phosphatidylinositol signaling system	33/1146	112/7206	0.000345494232903
ko05162	Measles	6/1146	120/7206	0.000355885577115
ko05140	Leishmaniasis	2/1146	75/7206	0.000388787919354
ko04612	Antigen processing and presentation	2/1146	77/7206	0.000408952366797
ko04730	Long-term depression	25/1146	78/7206	0.000440385424082
ko04371	Apelin signaling pathway	46/1146	177/7206	0.000524341659597
ko04014	Ras signaling pathway	66/1146	279/7206	0.000581822806634
ko05414	Dilated cardiomyopathy	32/1146	112/7206	0.000602487783955
ko04064	NF-kappa B signaling pathway	4/1146	96/7206	0.000603626101725
ko04966	Collecting duct acid secretion	11/1146	26/7206	0.00119775854234
ko00480	Glutathione metabolism	1/1146	55/7206	0.00132915641977
ko05161	Hepatitis B	13/1146	173/7206	0.00146194221677
ko05110	Vibrio cholerae infection	20/1146	63/7206	0.00150245243663
ko04750	Inflammatory mediator regulation of TRP channels	33/1146	122/7206	0.00158652975456
ko04976	Bile secretion	24/1146	80/7206	0.00170527225016
ko04110	Cell cycle	10/1146	145/7206	0.00176766848573
ko00590	Arachidonic acid metabolism	1/1146	52/7206	0.00200129208865
ko04630	Jak-STAT signaling pathway	9/1146	132/7206	0.00247496771339
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/1146	182/7206	0.00279907034377
ko04640	Hematopoietic cell lineage	2/1146	64/7206	0.00284702587989
ko04072	Phospholipase D signaling pathway	47/1146	197/7206	0.0029684312714
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1146	14/7206	0.00309034177884
ko00240	Pyrimidine metabolism	7/1146	110/7206	0.00361354520451
ko04626	Plant-pathogen interaction	8/1146	18/7206	0.0039168419107
ko00330	Arginine and proline metabolism	2/1146	61/7206	0.00409482057185
ko00260	Glycine, serine and threonine metabolism	1/1146	48/7206	0.00458381351842
ko04146	Peroxisome	5/1146	89/7206	0.00510867141707
ko04915	Estrogen signaling pathway	33/1146	131/7206	0.00529902620409
ko03022	Basal transcription factors	1/1146	44/7206	0.00678461625941
ko05144	Malaria	1/1146	45/7206	0.00679711366281
ko00071	Fatty acid degradation	1/1146	45/7206	0.00679711366281
ko01524	Platinum drug resistance	4/1146	76/7206	0.00696877903105
ko03420	Nucleotide excision repair	1/1146	46/7206	0.0070448556415
ko04657	IL-17 signaling pathway	5/1146	87/7206	0.00720427550454
ko00280	Valine, leucine and isoleucine degradation	2/1146	54/7206	0.00846862139179
ko05215	Prostate cancer	8/1146	111/7206	0.00861419388802
ko05321	Inflammatory bowel disease (IBD)	2/1146	56/7206	0.00882191773083
ko04217	Necroptosis	16/1146	178/7206	0.00916740289972
ko00310	Lysine degradation	4/1146	73/7206	0.00979950551967
ko03018	RNA degradation	5/1146	84/7206	0.0099130634325
ko00983	Drug metabolism - other enzymes	1/1146	42/7206	0.0101225147825
ko04923	Regulation of lipolysis in adipocytes	21/1146	77/7206	0.0110749857573
ko05166	HTLV-I infection	31/1146	292/7206	0.0110955385615
ko05145	Toxoplasmosis	10/1146	126/7206	0.0132604368902
ko04622	RIG-I-like receptor signaling pathway	3/1146	62/7206	0.0134855234836
ko04270	Vascular smooth muscle contraction	36/1146	154/7206	0.0139124733857
ko05131	Shigellosis	5/1146	82/7206	0.013931913227
ko04214	Apoptosis - fly	4/1146	72/7206	0.0139341866641
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1146	40/7206	0.0152599500215
ko04658	Th1 and Th2 cell differentiation	7/1146	96/7206	0.0166149505248
ko04964	Proximal tubule bicarbonate reclamation	10/1146	29/7206	0.0175369594923
ko05133	Pertussis	6/1146	87/7206	0.0177129953543
ko00380	Tryptophan metabolism	2/1146	50/7206	0.0181096655161
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1146	100/7206	0.0182827646177
ko00982	Drug metabolism - cytochrome P450	1/1146	37/7206	0.0225872276729
ko03410	Base excision repair	1/1146	38/7206	0.0232114346488
ko04930	Type II diabetes mellitus	15/1146	54/7206	0.0237063775083
ko00620	Pyruvate metabolism	2/1146	46/7206	0.0258121628842
ko00270	Cysteine and methionine metabolism	2/1146	47/7206	0.0259721323349
ko05219	Bladder cancer	2/1146	48/7206	0.0267368557666
ko04620	Toll-like receptor signaling pathway	8/1146	100/7206	0.027170962937
ko00562	Inositol phosphate metabolism	22/1146	89/7206	0.0280788665378
ko04210	Apoptosis	18/1146	180/7206	0.0295941099594
ko04140	Autophagy - animal	16/1146	164/7206	0.0301656940953
ko00500	Starch and sucrose metabolism	1/1146	35/7206	0.0340410472689
ko04115	p53 signaling pathway	5/1146	74/7206	0.0358127766622
ko04916	Melanogenesis	32/1146	142/7206	0.0362424036738
ko04015	Rap1 signaling pathway	57/1146	278/7206	0.036383781727
ko04330	Notch signaling pathway	4/1146	62/7206	0.0366761386153
ko00561	Glycerolipid metabolism	4/1146	63/7206	0.0367169784288
ko04918	Thyroid hormone synthesis	21/1146	86/7206	0.0370221685756
ko05222	Small cell lung cancer	7/1146	89/7206	0.0398394432232
ko04350	TGF-beta signaling pathway	9/1146	103/7206	0.0421774551183
ko04933	AGE-RAGE signaling pathway in diabetic complications	13/1146	135/7206	0.0433118754477
ko04668	TNF signaling pathway	11/1146	120/7206	0.0433303169506
ko04912	GnRH signaling pathway	28/1146	122/7206	0.0444751385223
ko05418	Fluid shear stress and atherosclerosis	18/1146	173/7206	0.0453872739528
ko04114	Oocyte meiosis	31/1146	139/7206	0.0456535139355
ko03320	PPAR signaling pathway	5/1146	69/7206	0.0469952517504
ko01200	Carbon metabolism	12/1146	128/7206	0.0498074802003